Mass Spectrometry Principles and Applications

ISBN-10: 0470033118

ISBN-13: 9780470033111

Edition: 3rd 2007 (Revised)

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Description: The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.

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Book details

List price: $76.00
Edition: 3rd
Copyright year: 2007
Publisher: John Wiley & Sons, Incorporated
Publication date: 10/29/2007
Binding: Paperback
Pages: 502
Size: 6.50" wide x 9.50" long x 1.25" tall
Weight: 2.112
Language: English

Edmond de HoffmannUniversit#180;e Catholique de Louvain, Belgium & Ludwig Institute forCancer Research, Brussels, BelgiumVincent StroobantLudwig Institute for Cancer Research, Brussels, Belgium

Preface
Introduction
Principles
Diagram of a Mass Spectrometer
History
Ion Free Path
Ion Sources
Electron Ionization
Chemical Ionization
Proton transfer
Adduct formation
Charge-transfer chemical ionization
Reagent gas
Negative ion formation
Desorption chemical ionization
Field Ionization
Fast Atom Bombardment and Liquid Secondary Ion Mass Spectrometry
Field Desorption
Plasma Desorption
Laser Desorption
Matrix-Assisted Laser Desorption Ionization
Principle of MALDI
Practical considerations
Fragmentations
Atmospheric pressure matrix-assisted laser desorption ionization
Thermospray
Atmospheric Pressure Ionization
Electrospray
Multiply charged ions
Electrochemistry and electric field as origins of multiply charged ions
Sensitivity to concentration
Limitation of ion current from the source by the electrochemical process
Practical considerations
Atmospheric Pressure Chemical Ionization
Atmospheric Pressure Photoionization
Atmospheric Pressure Secondary Ion Mass Spectrometry
Desorption electrospray ionization
Direct analysis in real time
Inorganic Ionization Sources
Thermal ionization source
Spark source
Glow discharge source
Inductively coupled plasma source
Practical considerations
Gas-Phase Ion-Molecule Reactions
Formation and Fragmentation of Ions: Basic Rules
Electron ionization and photoionization under vacuum
Ionization at low pressure or at atmospheric pressure
Proton transfer
Adduct formation
Formation of aggregates or clusters
Reactions at the interface between source and analyser
Mass Analysers
Quadrupole Analysers
Description
Equations of motion
Ion guide and collision cell
Spectrometers with several quadrupoles in tandem
Ion Trap Analysers
The 3D ion trap
The 2D ion trap
The Electrostatic Trap or 'Orbitrap'
Time-of-Flight Analysers
Linear time-of-flight mass spectrometer
Delayed pulsed extraction
Reflectrons
Tandem mass spectrometry with time-of-flight analyser
Orthogonal acceleration time-of-flight instruments
Magnetic and Electromagnetic Analysers
Action of the magnetic field
Electrostatic field
Dispersion and resolution
Practical considerations
Tandem mass spectrometry in electromagnetic analysers
Ion Cyclotron Resonance and Fourier Transform Mass Spectrometry
General principle
Ion cyclotron resonance
Fourier transform mass spectrometry
MS[superscript n] in ICR/FTMS instruments
Hybrid Instruments
Electromagnetic analysers coupled to quadrupoles or ion trap
Ion trap analyser combined with time-of-flight or ion cyclotron resonance
Hybrids including time-of-flight with orthogonal acceleration
Detectors and Computers
Detectors
Photographic plate
Faraday cup
Electron multipliers
Electro-optical ion detectors
Computers
Functions
Instrumentation
Data acquisition
Data conversion
Data reduction
Library search
Tandem Mass Spectrometry
Tandem Mass Spectrometry in Space or in Time
Tandem Mass Spectrometry Scan Modes
Collision-Activated Decomposition or Collision-Induced Dissociation
Collision energy conversion to internal energy
High-energy collision (keV)
Low-energy collision (between 1 and 100 eV)
Other Methods of Ion Activation
Reactions Studied in MS/MS
Tandem Mass Spectrometry Applications
Structure elucidation
Selective detection of target compound class
Ion-molecule reaction
The kinetic method
Mass Spectrometry/Chromatography Coupling
Elution Chromatography Coupling Techniques
Gas chromatography/mass spectrometry
Liquid chromatography/mass spectrometry
Capillary electrophoresis/mass spectrometry
Chromatography Data Acquisition Modes
Data Recording and Treatment
Data recording
Instrument control and treatment of results
Analytical Information
Mass Spectrometry Spectral Collections
High Resolution
Information at different resolving powers
Determination of the elemental composition
Isotopic Abundances
Low-mass Fragments and Lost Neutrals
Number of Rings or Unsaturations
Mass and Electron Parities, Closed-shell Ions and Open-shell Ions
Electron parity
Mass parity
Relationship between mass and electron parity
Quantitative Data
Specificity
Sensitivity and detection limit
External standard method
Sources of error
Internal standard method
Isotopic dilution method
Fragmentation Reactions
Electron Ionization and Fragmentation Rates
Quasi-Equilibrium and RRKM Theory
Ionization and Appearance Energies
Fragmentation Reactions of Positive Ions
Fragmentation of odd-electron cations or radical cations (OE[superscript [middle dot]+])
Fragmentation of cations with an even number of electrons (EE[superscript +])
Fragmentations obeying the parity rule
Fragmentations not obeying the parity rule
Fragmentation Reactions of Negative Ions
Fragmentation mechanisms of even electron anions (EE[superscript -])
Fragmentation mechanisms of radical anions (OE[superscript [middle dot]-])
Charge Remote Fragmentation
Spectrum Interpretation
Typical ions
Presence of the molecular ion
Typical neutrals
A few examples of the interpretation of mass spectra
Analysis of Biomolecules
Biomolecules and Mass Spectrometry
Proteins and Peptides
ESI and MALDI
Structure and sequence determination using fragmentation
Applications
Oligonucleotides
Mass spectra of oligonucleotides
Applications of mass spectrometry to oligonucleotides
Fragmentation of oligonucleotides
Characterization of modified oligonucleotides
Oligosaccharides
Mass spectra of oligosaccharides
Fragmentation of oligosaccharides
Degradation of oligosaccharides coupled with mass spectrometry
Lipids
Fatty acids
Acylglycerols
Bile acids
Metabolomics
Mass spectrometry in metabolomics
Applications
Exercises
Questions
Answers
Appendices
Nomenclature
Units
Definitions
Analysers
Detection
Ionization
Ion types
Ion-molecule reaction
Fragmentation
Acronyms and abbreviations
Fundamental Physical Constants
Table of Isotopes in Ascending Mass Order
Table of Isotopes in Alphabetical Order
Isotopic Abundances (in %) for Various Elemental Compositions CHON
Gas-Phase Ion Thermochemical Data of Molecules
Gas-Phase Ion Thermochemical Data of Radicals
Literature on Mass Spectrometry
Mass Spectrometry on Internet
Index
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