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| Preface | |
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| Abbreviations | |
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| Introduction | |
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| Some General Remarks About Cancer and Cancer Chemotherapy | |
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| A Brief Account of the Role of Chemistry in Cancer Chemotherapy | |
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| Natural Products in Cancer Chemotherapy | |
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| A Brief Comment About Cancer Nanotechnology | |
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| Conclusion | |
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| References | |
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| Antimetabolites | |
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| Introduction | |
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| Inhibitors of the Biosynthesis of Uridylic Acid | |
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| Inhibitors of the Biosynthesis of 2'-Deoxyribonucleotides by Ribonucleotide Reductase (RNR) | |
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| Inhibitors of the Biosynthesis of Thymidilic Acid | |
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| Inhibitors of Dihydrofolate Reductase (DHFR) | |
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| Inhibitors of the De Novo Purine Biosynthesis Pathway | |
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| Inhibitors of Adenosine Deaminase | |
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| Inhibitors of Late Stages in DNA Synthesis | |
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| Antimetabolite Enzymes | |
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| References | |
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| Anticancer Drugs That Inhibit Hormone Action | |
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| Introduction | |
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| Estrogens and Their Involvement in Carcinogenesis | |
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| Antiestrogens as Antitumor Drugs | |
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| Aromatase Inhibitors | |
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| Steroid Sulfatase Inhibitors | |
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| Androgen-Related Antitumor Agents | |
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| Regulation of Steroidal Hormone Synthesis as a Target for Antitumor Drugs | |
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| Miscellaneous Steroid Hormone-Related Anticancer Therapy | |
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| Compounds Acting on Other Proteins of the Nuclear Receptor Superfamily: Retinoids | |
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| References | |
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| Anticancer Drugs Acting via Radical Species, Photosensitizers and Photodynamic Therapy of Cancer | |
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| Introduction: Radicals and Other Reactive Oxygen Species | |
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| Biological Effects of ROS | |
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| Anthracyclines and Their Analogs | |
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| Mitoxantrone and Related Quinones | |
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| Actinomycin D | |
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| Chartreusin, Elsamicin A, and Related Compounds | |
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| Bleomycins | |
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| Enediyne Antibiotics | |
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| Tirapazamine | |
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| Penclomedine | |
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| Radiosensitizers | |
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| Photodynamic Therapy of Cancer | |
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| References | |
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| DNA Alkylating Agents | |
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| Introduction | |
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| Nitrogen Mustards | |
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| Aziridines (Ethyleneimines) | |
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| Epoxides | |
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| Methanesulfonates | |
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| Nitrosoureas | |
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| Triazenes | |
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| Methylhydrazines | |
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| 1,3,5-Triazines: Hexamethylmelamine and Trimelamol | |
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| Platinum Complexes | |
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| Miscellaneous Alkylating and Acylating Antitumor Agents | |
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| References | |
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| Alkylating and Non-Alkylating Compounds Interacting with the DNA Minor Groove | |
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| Introduction | |
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| Netropsin, Distamycin, and Related Compounds | |
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| Mitomycins | |
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| Tetrahydroisoquinoline Alkaloids | |
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| Cyclopropylindole Alkylating Agents | |
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| Pyrrolo[1,4]Benzodiazepines | |
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| References | |
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| DNA Intercalators and Topoisomerase Inhibitors | |
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| DNA Intercalation and Its Consequences | |
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| Monofunctional Intercalating Agents | |
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| Bifunctional Intercalating Agents | |
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| DNA Topoisomerases | |
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| Topoisomerase II Poisons | |
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| Topoisomerase II Catalytic Inhibitors | |
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| Specific Topoisomerase I Inhibitors | |
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| References | |
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| Anticancer Drugs Targeting Tubulin and Microtubules | |
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| Introduction | |
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| Drugs That Inhibit Microtubule Polymerization at High Concentrations | |
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| Microtubule-Stabilizing Agents: Compounds Binding at the Taxane Site | |
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| Miscellaneous Anticancer Drugs Acting on Novel Sites on Tubuline | |
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| Antivascular Effects of Microtubule-Targeted Agents | |
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| Mitotic Kinesin Inhibitors | |
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| References | |
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| Drugs That Inhibit Signalling Pathways for Tumor Cell Growth and Proliferation | |
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| Introduction: The Role of Protein Kinases in Cancer | |
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| Signalling Pathways Related to Kinases | |
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| Inhibitors of Tyrosine Kinases (TKs) | |
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| Inhibitors of Serine-Threonine Kinases | |
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| Inhibitors of the RAS-RAF-MEK Signalling Pathway and Farnesyl Transferase | |
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| Inhibitors of Farnesyldiphosphate Synthase and Geranylgeranyldiphosphate Synthase | |
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| Anticancer Drugs Acting on Apoptotic Signalling Pathways | |
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| Inhibitors of Heat-Shock Proteins (HSP 90) | |
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| References | |
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| Other Approaches to Targeted Therapy | |
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| Proteasome Inhibitors | |
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| Antiangiogenic Agents Unrelated to Kinase Signaling | |
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| Epigenetic Therapy of Cancer | |
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| Inhibitors of Other DNA-Associated Enzymes | |
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| Therapy Directed at Other Targets | |
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| References | |
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| Drug Targeting in Anticancer Chemotherapy | |
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| Introduction | |
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| Prodrug-Based Anticancer Drug Targeting: Small-Molecule Prodrugs | |
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| Polymer-Protein Conjugates | |
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| Macromolecular Small-Drug Carrier Systems | |
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| Polymer-Directed Enzyme Prodrug Therapy (PDEPT) | |
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| Folate Receptor-Targeted Chemotherapy and Immunotherapy of Cancer | |
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| Liposomes and Nanoparticles in Anticancer Drug Targeting | |
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| References | |
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| Drugs That Modulate Resistance to Antitumor Agents | |
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| ATP-Binding Cassette Efflux Pumps in Anticancer Drug Resistance | |
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| Glutathione and Glutathione-S-Transferase in Anticancer Drug Resistance | |
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| Chemosensitizers Targeting DNA-Repair Systems | |
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| Antitumor Drug Resistance Related to Extracellular pH: Tumor-Associated Carbonic Anhydrase as an Anticancer Target | |
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| References | |
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| Cancer Chemoprevention | |
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| Introduction | |
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| Ligands for Nuclear Receptors in Cancer Chemoprevention | |
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| Anti-Inflammatory Agents and Antioxidants in Cancer Chemoprevention | |
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| Chromatin Modifiers in Cancer Chemoprevention | |
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| Miscellaneous Agents for Chemoprevention | |
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| Cancer Vaccines | |
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| References | |
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| Index | |