Introduction to Toxicology

ISBN-10: 0415247632
ISBN-13: 9780415247634
Edition: 3rd 2001 (Revised)
Authors: John A. Timbrell
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Description: Since the publication of the first edition of Introduction to Toxicology , toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text  More...

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Book details

List price: $59.95
Edition: 3rd
Copyright year: 2001
Publisher: CRC Press LLC
Publication date: 11/15/2001
Binding: Paperback
Pages: 215
Size: 7.25" wide x 9.50" long x 0.50" tall
Weight: 0.902
Language: English

Since the publication of the first edition of Introduction to Toxicology , toxicology has become a more mature science, the number of undergraduate and postgraduate courses has increased and thus the need for a regularly updated introductory text has become more pressing.This third edition caters for this need in a clear and easy-to-read style, featuring:* Up-to-the-minute information* Relevant toxicological examples that reinforce principles* End-of-chapter essay questions* New and redrawn illustrations* Glossary of terms* Extensively revised bibliographyThe fundamental principles of absorption, distribution, metabolism and excretion are described in the introductory chapters, as are the types of exposure and response. In subsequent chapters these are clarified with the use of carefully chosen examples. Among the topics considered are the potential adverse effects of drugs, pesticides, food additives and industrial chemicals.

Preface to the First Edition
Preface to the Third Edition
Introduction
Chapter outline
Historical aspects
Types of toxic substance
Types of exposure
Dose-response relationship
Summary and learning objectives
Questions
Bibliography
Disposition of Toxic compounds
Chapter outline
Absorption of toxic compounds
Distribution of toxic compounds
Excretion of toxic compounds
Summary and learning objectives
Questions
Bibliography
Metabolism of Foreign Compounds
Chapter outline
Introduction
Factors affecting toxic responses
Summary and learning objectives
Questions
Bibliography
Types of Exposure and Response
Chapter outline
Types of exposure
Route of exposure
Types of toxic response
Biomarkers
Summary and learning objectives
Questions
Bibliography
Drugs as Toxic Substances
Chapter outline
Introduction
Paracetamol
Aspirin (salicylate)
Hydralazine
Halothane
Debrisoquine
Thalidomide
Drug interactions
Altered responsiveness: glucose-6-phosphate dehydrogenase deficiency
Summary and learning objectives
Questions
Bibliography
Industrial Toxicology
Chapter outline
Industrial chemicals
Means of exposure
Toxic effects
Vinyl chloride
Cadmium
Aromatic amines
Asbestos
Legislation
Summary and learning objectives
Questions
Bibliography
Food Additives and Contaminants
Chapter outline
Introduction
Tartrazine
Saccharin
Food contaminants
Summary and learning objectives
Questions
Bibliography
Pesticides
Chapter outline
Introduction
DDT
Organophosphorus compounds
Paraquat
Fluoroacetate
Summary and learning objectives
Questions
Bibliography
Environmental Pollutants
Chapter outline
Introduction
Air pollution
Particulates
Acid rain
Lead pollution
Water pollution
Arsenic
Food chains
Endocrine disruptors
Mercury and methylmercury
Summary and learning objectives
Questions
Bibliography
Natural Products
Chapter outline
Plant toxins
Animal toxins
Fungal toxins
Microbial toxins
Summary and learning objectives
Questions
Bibliography
Household Products
Chapter outline
Introduction
Carbon monoxide
Antifreeze: ethylene glycol
Cyanide
Alcohol
Glue sniffing and solvent abuse
Antidotes and the treatment of poisoning
Summary and learning objectives
Questions
Bibliography
Toxicity Testing and Risk Assessment
Chapter outline
Introduction
Evaluation of toxicity
Acute toxicity tests
Sub-acute toxicity tests
Chronic toxicity tests
Testing in vitro
Risk assessment and interpretation of toxicological data
Conclusions
Summary and learning objectives
Questions
Bibliography
Answers to questions
Glossary
Index

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