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HLA System in Clinical Transplantation Basic Concepts and Importance

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ISBN-10: 0387554564

ISBN-13: 9780387554563

Edition: 1993

Authors: Soldano Ferrone, Bjarte G. Solheim, E. Moller

List price: $179.00
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Book details

List price: $179.00
Copyright year: 1993
Publisher: Springer
Binding: Hardcover
Pages: 350
Language: English

Introduction
The Life and Times of the Human Major Histocompatibility Complex
Origins of Mhc Diversity
Genetics, Chemistry and Expression
MHC Genes
Class I and Class II HLA Proteins and Genes: An Overview of Structure, Polymorphism, and Expression
Assembly and Intracellular Transport of MHC Molecules
Regulation and Deregulation of HLA Class II Genes
Minor Transplantation Antigens
Biological Function of MHC Molecules
Biological Function of HLA Molecules
MHC Molecules in Thymic Development and Selection of the T Cell Repertoire
The Molecular Mechanisms of HLA Associated Autoimmunity
The Capacity of Class I MHC Molecules to Function as Signal Transduction Elements
The Major Histocompatibility Complex and Cell Physiology
MHC Control of Growth and Metastatic Properties of Tumor Cells
Allorecognition of HLA Molecules
HLA Molecules in Allorecognition: T Cell Recognition and Typing Methods
B Cell Recognition and HLA Typing: Current Methods and Future Possibilities. Role of Alloantibodies and Monoclonal Antibodies as Reagents
HLA Antibodies, Non-HLA Antibodies, and Crossmatch Methods
Transplantation of the Alloimmunized Patient
HLA-Matching
HLA Matching in Clinical Organ Transplantation
Transplantation Tolerance and Noninherited Maternal HLA Antigens
What To Do with the Immunized Patient. How to Avoid Humoral Immunization
Immunosuppression
Immunosuppressive Therapy
Selective Depletion of Alloreactive Cells in Transplantation
Immunological Considerations on the Use of Monoclonal Antibodies for In Vitro and In Vivo Modification of Alloimmunity
Anti-idiotypic Antibodies in the HLA System
Rejection
Cellular and Molecular Mechanism of Rejection and Role of Viral Infection
Fine-Needle Aspiration Biopsy in Rejection Diagnosis
Bone Marrow Transplantation
Bone Marrow Transplantation Using Related Donors
Marrow Transplantation from Unrelated Donors
Purging of Bone Marrow
Xenografting
Xenografting: Is It Feasible?
Malignancy after Transplantation
Tumors in Transplanted Patients
Addendum
Nomenclature for the Major Histocompatibility Complexes of Different Species: A Proposal
Revised Nomenclature of Mouse H-2 Genes
Subject Index