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Molecular Biology of Cancer Mechanisms, Targets, and Therapeutics

ISBN-10: 019957717X
ISBN-13: 9780199577170
Edition: 3rd 2012
Authors: Lauren Pecorino
List price: $35.99
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Book details

List price: $35.99
Edition: 3rd
Copyright year: 2012
Publisher: Oxford University Press
Publication date: 5/24/2016
Binding: Paperback
Pages: 360
Size: 7.25" wide x 9.25" long x 0.75" tall
Weight: 1.386
Language: English

Lauren Pecorino is Principal Lecturer in Cancer Biology at the University of Greenwich. She has presented guest lectures in Rome and Palermo, Italy; Istanbul, Turkey; Cairo, Egypt and the United States.

Introduction
What is cancer?
Evidence suggests that cancer is a disease of the genome at the cellular level
Influential factors in human carcinogenesis
Principles of conventional cancer therapies
Clinical trials
The role of molecular targets in cancer therapies
DNA structure and stability: mutations versus repair
Gene structure-two parts of a gene: the regulatory region and the coding region
Mutations
Carcinogenic agents
DNA repair and predispositions to cancer
Therapeutic strategies
Conventional therapies: chemotherapy and radiation therapy
Strategies that target DNA repair pathways
Regulation of gene expression
Transcription factors and transcriptional regulation
Chromatin structure
Epigenetic regulation of transcription
Evidence of a role for epigenetics in carcinogenesis
Telomeres and telomerase
MicroRNAs (miRNAs) and regulation of mRNA expression
Therapeutic strategies
Epigenomic and histonomic drugs
Telomerase inhibitors
Growth factor signaling and oncogenes
Epidermal growth factor signaling: an important paradigm
Oncogenes
Therapeutic strategies
Kinases as drug targets
The cell cycle
Cyclins and cyclin-dependent kinases (cdks)
Mechanisms of cdk regulation
Progression through the G<sub>1</sub> checkpoint
The 6<sub>2</sub> checkpoint
The mitotic checkpoint
The cell cycle and cancer
Therapeutic strategies
Cyclin-dependent kinase inhibitors
Other cell cycle kinase targets
Inhibitors of the mitotic spindle
Growth inhibition and tumor suppressor genes
Definitions of tumor suppressor genes
The retinoblastoma gene
Mutations in the RB pathway and cancer
The p53 pathway
Mutations in the p53 pathway and cancer
Interaction of DNA viral protein products with RB and p53
Therapeutic strategies
Targeting of the p53 pathway
Apoptosis
Molecular mechanisms of apoptosis
Apoptosis and cancer
Apoptosis and chemotherapy
Therapeutic strategies
Apoptotic drugs
Stem cells and differentiation
Stem cells and cancer
Differentiation and the regulation of transcription
Therapeutic strategies
Inhibitors of the Wnt pathway
Inhibitors of the Hh pathway
Leukemia and differentiation therapies
Metastasis
The process of metastasis
Tools of cell invasion: cell adhesion molecules, integrins, and proteases
Intravasation
Transport
Extravasation
Metastatic colonization
Angiogenesis
Other means of tumor neovascularization
Therapeutic strategies
Metalloproteinase inhibitors (MPIs)
Strategies for restoring metastasis suppressors
Anti-angiogenic therapy and vascular targeting
Targeting several steps of metastasis at once
The immune system, infections, and inflammation
The immune system and cancer
Identifying infectious agents as carcinogens
Inflammation and cancer
Therapeutic strategies
A national vaccination program against hepatitis B virus in Taiwan
Eradication of H. pylori and the relationship to prevention of gastric cancer
Cancer vaccines to prevent cervical cancer
Inhibition of inflammation
Nutrients, hormones, and gene interactions
Causative factors
Preventative factors: microconstituents of fruits and vegetables
Reprogramming energy metabolism in tumor cells-an emerging hallmark of cancer
Genetic polymorphisms and diet
Vitamin D: a link between nutrients and hormone action
Hormones and cancer
Therapeutic strategies
"Enhanced" foods and dietary supplements for chemoprevention
Drugs that target energy pathways
Drugs that target estrogen
The cancer industry: drug development, pharmacogenomics, and clinical trial design
Strategies of drug development
Development of imatinib
Second- and third-generation therapeutics
Pharmacogenomics
Improved clinical trial design
A career in cancer research
Cancer in the future: focus on cancer vaccines and technology
Cancer vaccines
Microarrays and gene expression profiling
Diagnostics and prognostics
Imaging
Personalized medicine and bioinformatics
Cancer nanotechnology
Treating cancer symptoms
Are we making progress?
Cell Cycle Regulation
Centers For Cancer Research
Glossary
Index

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