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| Foreword | |
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| Introduction | |
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| The Plant | |
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| Consumption of Cannabis: Preparations for Their Psychoactive Effects | |
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| Smoking | |
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| Eating and Drinking | |
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| A Brief History | |
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| The Pharmacology of Delta-9-Tetrahydrocannabinol (THC), The Psychoactive Ingredient in Cannabis | |
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| Man-Made Cannabinoids | |
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| Cannabinoid Antagonists | |
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| How Does THC Get to the Brain? | |
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| Smoking | |
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| Oral Absorption | |
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| Other Routes of Administration | |
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| Elimination of THC From the Body | |
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| How Does THC Work? | |
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| Discovery of Cannabinoid Receptors | |
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| Neuroanatomical Distribution of CB-1 Receptors in the Brain | |
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| Some Physiological Effects of THC | |
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| Inhibition of Neurotransmitter Release | |
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| Effects on the Heart and Blood Vessels | |
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| Effects on Pain Sensitivity | |
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| Effects on Motility and Posture | |
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| The Billy Martin Tetrad | |
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| Endocannabinoids | |
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| Discovery of Naturally Occurring Endocannabinoids-The Endocannabinoids | |
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| Biosynthesis and Inactivation of Endocannabinoids | |
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| Physiological Functions of Endocannabinoids | |
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| Retrograde Signal Molecules at Synapses | |
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| Control of Energy Metabolism and Body Weight | |
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| Regulation of Pain Sensitivity | |
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| Cardiovascular Control | |
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| Other Functions | |
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| Development of a New Endocannabinoid-Based Pharmacology | |
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| Novel Cannabinoid Receptor Agonists or Antagonists | |
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| Inhibitors of Endocannabinoid Inactivation | |
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| The Effects of Cannabis on the Central Nervous System | |
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| Subjective Reports of the Marijuana High | |
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| Laboratory Studies of Marijuana in Human Volunteers | |
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| Effects on Movement and Driving | |
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| Higher Brain Function, Including Learning and Memory | |
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| Comparisons of Marijuana With Alcohol | |
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| What Can Animal Behavior Experiments Tell Us? | |
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| Does Repeated Use of Marijuana Lead to Tolerance and Dependence? | |
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| Medical Uses of Marijuana-Fact or Fantasy? | |
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| Historical | |
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| The Modern Revival of Interest in Cannabis-Based Medicines | |
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| The Synthetic Cannabinoids | |
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| Dronabinol (Marinol) | |
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| Nabilone (Cesamet) | |
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| Medical Targets for Cannabis | |
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| Multiple Sclerosis | |
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| Pain | |
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| Nausea and Vomiting Associated With Cancer Chemotherapy | |
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| AIDS Wasting Syndrome | |
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| Other Potential Medical Targets | |
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| Epilepsy | |
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| Bronchial Asthma | |
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| Moods Disorders and Sleep | |
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| Cancer | |
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| Diarrhea | |
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| Emerging Indications | |
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| Is There Any Role for Smoked Marijuana as a Medicine? | |
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| A Cannabinoid Antagonist for the Treatment of Obesity | |
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| Preclinical Data | |
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| Clinical Data | |
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| Conclusions | |
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| Is Cannabis Safe? | |
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| Toxicity | |
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| Acute Effects of Cannabis | |
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| Effects of Long-Term Exposure to Cannabis | |
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| Are There Persistent Cognitive Deficits? | |
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| Tolerance and Dependence | |
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| Adverse Effects on Fertility and the Unborn Child | |
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| Suppression of Immune System Function | |
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| Cannabis and Mental Illness | |
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| Special Hazards of Smoked Marijuana | |
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| Marijuana Smoke and Smoking Behavior | |
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| Effects of Marijuana Smoke on the Lungs | |
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| Marijuana Smoking and Lung Cancer | |
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| Summary | |
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| The Recreational Use of Cannabis | |
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| Prevalence | |
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| How Is Cannabis Consumed and Where Does It Come From? | |
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| Patterns of Recreational Use | |
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| What Are the Effects of Recreational Cannabis Use? | |
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| The Potency of Illicit Marijuana | |
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| Is Marijuana a Gateway Drug? | |
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| Do Recreational Marijuana Users Become Dependent? | |
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| Forensic Testing for Cannabis-Growth Industry | |
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| Snapshots of Cannabis Use Around the World | |
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| India and Pakistan | |
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| Nepal and Tibet | |
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| Southeast Asia | |
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| Africa | |
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| Caribbean and Latin America | |
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| Conclusions | |
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| What Next? A Hundred Years of Cannabis Reports | |
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| A Hundred Years of Cannabis Inquiries | |
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| The Indian Hemp Drugs Commission Report (1894) | |
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| Mayor La Guardia's Report, The Marihuana Problem in the City of New York (1944) | |
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| The Wooton Report, England (1969) | |
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| Report Followed Report | |
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| The Dutch Experiment | |
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| What Next? Is There a Case for the Legalization/Decriminalization/Depenalization of Cannabis? | |
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| References | |
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| Index | |