Cancer Biology

ISBN-10: 0195175441
ISBN-13: 9780195175448
Edition: 4th 2007 (Revised)
List price: $78.00 Buy it from $48.85
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Book details

List price: $78.00
Edition: 4th
Copyright year: 2007
Publisher: Oxford University Press, Incorporated
Publication date: 3/29/2007
Binding: Paperback
Pages: 568
Size: 6.75" wide x 9.75" long x 1.25" tall
Weight: 2.486
Language: English

Characteristics of Human Cancer
What Everyone Wants to Know about Cancer
Patients
Physicians and Health Care Professionals
Cancer Researchers
What is Cancer?
Definition of Cancer
Description of Cancer
What Significant Events Have Happened in Cancer Research in the Last 20 Years?
Basic Facts about Cancer
Hallmarks of Malignant Diseases
Classification of Human Cancers
Macroscopic and Microscopic Features of Neoplasms
Grade and Stage of Neoplasms
Histologic Grade of Malignancy
Tumor Staging
Causes of Cancer
The Theory of "Hits"
Chemical Carcinogenesis
Historical Perspectives
Metabolic Activation of Chemical Carcinogens
Donors of simple alkyl groups
Cytochrome P-450-mediated activation
2-acetylaminofluorene
Other aromatic amines
Polycyclic aromatic hydrocarbons
DNA Adduct Formation
Interaction of Chemical Carcinogens with Oncogenes and Tumor Suppressor Genes
Carcinogen-Induced Epigenetic Changes
Tumor Initiation, Promotion, and Progression
Mechanisms of tumor initiation
Endogenous carcinogenesis
Mechanisms of tumor promotion and progression
Central dogma of tumor progression
Mechanisms of tumor-promoting agents
Experimental Models for the Study of Carcinogenesis
Validity of Tests for Carcinogenicity
Irradiation Carcinogenesis
Ionizing Radiation
Ultraviolet Radiation
Oxygen Free Radicals, Aging, and Cancer
Genetic Susceptibility and Cancer
Multiple Mutations in Cancer
DNA Repair Mechanisms
Viral Carcinogenesis
Historical Perspectives
Role of Viruses in the Causation of Human Cancer
Association of Epstein-Barr virus and human cancers
Hepatitis virus and hepatocellular carcinoma
Papillomaviruses and cervical cancer
HTLV-1 and adult T-cell leukemia
The Epidemiology of Human Cancer
Trends in Cancer Incidence and Mortality
U.S. Data
Cancer Is a Clobal Problem
Data for Some Prevalent Human Cancers
Lung Cancer
Breast Cancer
Colorectal Cancer
Liver Cancer
Pancreatic Cancer
Cancers of the Female Reproductive Tract
Cervical cancer
Ovarian cancer
Endometrial cancer
Prostate Cancer
Urinary Bladder Cancer
Lymphoma
Leukemia
Skin Cancer
Cancers of the Central Nervous System
Role of Various Factors in the Development of Cancers
Cigarette Smoking
Alcohol
Diet
Sexual Development, Reproductive Patterns, and Sexual Behavior
Industrial Chemicals and Occupational Cancers
Herbicides
Air and Water Pollutants
Radiation
Ultraviolet
Ionizing radiation
Radon
Drugs
Hormones
Infection
Aging and Cancer
Genetic Factors in Cancer
Inherited Cancers
Gene Environment Interactions
Avoidability of Cancer
Risk Assessment
The Great Cancer Myths
Passive Smoking
Radon in the Home
Cell Phones
Electromagnetic Fields
Alcohol
Organochlorine Compounds, Polycyclic Aromatic Hydrocarbons, and Breast Cancer
Antiperspirants
Water Chlorination
Abortion or Miscarriage and Breast Cancer
Asbestos
Saccharin
Acrylamide in Foods
Alar
SV40 Virus in Early Polio Vaccines
The Biochemistry and Cell Biology of Cancer
Historical Perspectives
Growth Characteristics of Malignant Cells
Phenotypic Alterations in Cancer Cells
Immortality of Transformed Cells in Culture
Decreased Requirement for Growth Factors
Loss of Anchorage Dependence
Loss of Cell Cycle Control and Resistance to Apoptosis
Changes in Cell Membrane Structure and Function
Alterations in cell surface glycolipids, glycoproteins, proteoglycans, and mucins
Role of glycosyl transferases and oligosaccharide processing enzymes
Mucins
Proteoglycans
Modification of Extracellular Matrix Components
Cell-Extracellular Matrix and Cell-Cell Adhesion
Cell Proliferation versus Differentiation
Mechanisms of Cellular Differentiation
Slime molds
Yeast
Sea urchin
Drosophilia melanogaster
Mouse
Pathways: getting to know all the players
Stimulation of cancer cell differentiation
Stem Cells
Cell Cycle Regulation
Historical Perspectives
The Molecular Players
Cyclin-dependent protein kinases
CDK inhibitors
Cyclins
Cell cycle checkpoints
Cell cycle regulatory factors as targets for anticancer agents
Apoptosis
Historical Perspectives
Biochemical Mechanisms of Apoptosis
Caspases
Bcl-2 family
Role of mitochondria in apoptosis
Anoikis
Resistance to Apoptosis in Cancer and Potential Targets for Therapy
Growth Factors
Historical Perspectives
Insulin
Insulin-Like Growth Factors
Nerve Growth Factor
Epidermal Growth Factor
Fibroblast Growth Factor
Platelet-Derived Growth Factor
Transforming Growth Factors
TGF-[alpha]
TGF-[Beta]
Hematopoietic Growth Factors
Hepatocyte Growth Factor and Scatter Factor
Miscellaneous Growth Factors
Signal Transduction Mechanisms
Some Key Signal Transduction Concepts
Transcriptional regulation by signal transduction
Protein-protein interaction domains
Spatial and temporal regulation
Signaling networks and crosstalk
Overview of Some Signal Transduction Pathways Important in Cancer
G protein-linked receptors
The phosphoinositide 3-kinase pathway
mTOR
Tyrosine kinase pathways
Protein phosphatases
JAK-STAT pathway
Estrogen receptor pathway
Hypoxia-inducible factor
Tumor necrosis factor receptor signaling
Tumor growth factor-[Beta] signal transduction
Heat shock protein-mediated events
Angiogenesis
Vascular Endothelial Growth Factor
Platelet-Derived Growth Factor
Angiopoietins
Ephrins
Angiogenesis Inhibitors
Inhibitors of proangiogenic factors
Metalloproteinases
Integrins
Endogenous inhibitors
HIF-1[alpha]
Miscellaneous anti-angiogenic agents
Clinical data
Lymphangiogenesis
Tumor Dormancy
Biology of Tumor Metastasis
The "Classic" Theory of Tumor Metastasis
Alternate Theory of Tumor Metastasis
Invasion and Metastasis: The Hallmarks of Malignant Neoplasia
Metastasis Is at Least Partly a Selective Process
Biochemical Characteristics of Metastatic Tumor Cells
Relationship of cancer metastasis to normal tissue invasion events
Role of lytic enzymes in the metastasis cascade
Role of plasma membrane components in metastasis
Role of extracellular matrix components and the basement membranes in tumor metastasis
Tissue adhesion properties of metastatic cells
Ability of metastatic tumor cells to escape the host's immune response
Chemotactic factors in cancer cell migration
Role of oncogenes in tumor metastasis
Identification of the "Metastatic Genes" and "Metastasis Suppressor Genes"
Molecular Genetics of Cancer
Chromatin Structure and Function
Components of Chromatin
Chemical Modifications of Chromatin-Associated Proteins
Packaging of Chromatin
Structure and Function of Interphase Chromosomes
Nuclear Organization
Nuclease Sensitivity
Transcriptional Activation and the Cancer Connection
Control of Gene Expression during Embryonic Stem Cell Differentiation
Split Genes and RNA Processing
Genetic Recombination
Gene Amplification
Cis-Acting Regulatory Elements: Promoters and Enchancers
Transcription Factors
Structural Motifs of Regulatory DNA-Binding Proteins
Repressors
General (Basal) Transciption Factors
Promoter- and Enhancer-Specific Transcription Factors
AP-1/Fos/Jun
ATF/CREB
SP1
Oct-3
The superfamily of hormone receptors
YY1
LEF-1
E2F
Tissue specific transcription factors
MyoD
Liver specific transcription factors
Pit-1
E2A
NF-[Kappa]B
POU-domain binding proteins
Ets1 and Ets2
Homeobox proteins
DNA Methylation
DNA Methyltransferases
Methyl DNA Binding Proteins
DNA Methylation and Cancer
Genomic Imprinting
Loss of Heterozygosity
Telomeres and Telomerase
Post-transcriptional Regulation
Molecular Genetic Alterations in Cancer Cells
Translocations and Inversions
Chromosomal Deletions
Gene Amplification
Point Mutations
Aneuploidy
Disomy
Trinucleotide Expansion
Microsatellite Instability
Mismatch DNA Repair Defects
Gene Derepression in Cancer Cells
Ectopic hormone production by human cancers
Possible mechanisms of ectopic protein production
Chromosomal Abnormalities in Leukemic Patients Exposed to Genotoxic Agents
Cancer Genetic Changes Summed Up
Oncogenes
Historical Perspectives
The provirus, protovirus, and oncogene hypothesis
The src gene
Oncogene Families
Cell Transforming Ability of onc Genes
Functional Classes of Oncogenes
Characteristics of Individual Oncogenes
ras
myc
src
jun and fos
ets
bcr-abl
myb
bcl-2
NF-KB/rel
erbA
sis
erbB
erbB-2 (Her-2/neu)
Other growth factor or growth factor receptor oncogenes
fms
kit
trk
met
Pokemon
Cellular onc Gene Expression during Normal Embryonic Development
DNA Tumor Viruses
SV40 and Polyoma
Papilloma Viruses E6 and E7
Adenoviruses E1A and E1B
Hepatitis B Virus
Herpes Viruses
Tumor Suppressor Genes
Historical Perspectives
Properties of Individual Tumor Suppressor Genes
rb
Characterization of the rb protein
Interactions of Rb proteins
Role of rb in reversing the malignant phenotype
Requirement of a functional rb-1 gene in development
Cell cycle regulation by Rb
Interactions of Rb protein with transcription factors and DNA regulatory elements
p53
Characteristics of p53 and its mutations
Mutagenesis of p53
Ability of p53 to reverse cellular transformation and tumorigenesis
Role of p53 in cell cycle progression and in inducing apoptosis
Mechanism of p53's actions
Wilms' tumor suppressor gene wt-1
Adenomatous polyposis coli (apc) gene
Deleted in colorectal cancer (dcc) gene
Hereditary nonpolyposis colorectal cancer (hnpcc) gene
Neurofibromatosis genes nf-1 and nf-2
Von Hippel-Lindau syndrome and renal cell carcinoma gene
BRCA1 and BRCA2
Identification of Tumor Suppressor Genes
Mechanisms of Gene Silencing
Antisense
Ribozymes
DNAzymes
RNAi
Transitive RNAi
Micro-RNA
Small temporal RNA
Short hairpin RNA
Gene Therapy
Gene Therapy for Cancer
Personalized Medicine and Systems Biology
Tumor Immunology
Historical Perspectives
Mechanisms of the Immune Response to Cancer
Antigen Presenting Cells
How Antigens Are Processed
T Lymphocytes and T Cell Activation
The Immunological Synapse
B Lymphocytes and B Cell Activation
Natural Killer Cells
Cell-Mediated Cytotoxicity
Danger Theory
Role of Gene Rearrangement in the Tumor Response
Heat Shock Proteins as Regulators of the Immune Response
Inflammation and Cancer
Immunotherapy
Rationale for Immunotherapy
Identification and Characterization of Tumor-Derived Antigenic Peptides
Cytokines
Interferons
Interleukins
Tumor necrosis factor
Adoptive Immunotherapy
Vaccines
Monoclonal Antibodies
How Tumor Cells Avoid the Immune Response
Cancer Diagnosis
Medical and Scientific Drivers for Expanded Cancer Diagnostic Techniques
Categories of Tumor Markers
Nucleic Acid-Based Markers
Cancer-associated mutations
Loss of heterozygosity and microsatellite instability
DNA methylation patterns
Mitochondrial DNA mutations
Viral DNA
Gene Expression Microarrays
Laser-Capture Microdissection
Comparative Genome Hybridization
Tissue Arrays
Gene Expression Microarrays in Individual Cancer Types
Lymphoma
Leukemia
Breast cancer
Ovarian cancer
Prostate cancer
Colorectal cancer
Lung cancer
Renal cancer
Hepatic cancer
Other cancers and cancer-related phenotypes
Proteomics
Proteomics Methods
Two-dimensional electrophoresis
Isotope-coded affinity tags (ICAT)
Mass spectrometry-based proteomics
Protein chips
Surface-enhanced laser desorption/ionization (SELDI)
Yeast two-hybrid system
Phage display
Organelle proteomics
Plasma proteome
Tissue proteomics: imaging mass spectrometry
Pattern recognition
The unfolded protein response
Proteomics in Cancer Diagnosis
Lung cancer
Ovarian cancer
Breast cancer
Prostate cancer
Pancreatic cancer
Circulating Epithelial Cells
Circulating Endothelial Cells and Endothelial Progenitor Cells
Molecular Imaging
Protein-Protein Interactions
Protein Degradation
Imaging Gene Expression In Vivo
Bioluminescent detection
Magnetic Resonance Spectroscopy
Ultrasound Imaging
Nanotechnology
Gray Goo
Pharmacogenomics and Pharmacogenetics
Importance of Pharmacogenomics in Cancer
Haplotype Mapping
Sequelae of Cancer and Its Treatment
Patient-Tumor Interactions
Pain
Nutritional Effects
Hematologic Effects
Erythropoiesis
Leukopoiesis
Platelets
Thrombosis
Fever and Infection
Hormonal Effects
Hypercalcemia
Neurologic Effects
Dermatologic Effects
Fatigue
Sequelae of Cancer Treatment
Cancer Prevention
Molecular Mechanisms of Aging and Its Prevention
Somatic Mutation
Telomere Loss
Mitochondrial Damage
Formation of Oxygen-Free Radicals
Cell Senescence
DNA Repair and Genome Stability
Caloric Restriction
Diet and Cancer Prevention
Chemoprevention
Molecular Targets for Chemoprevention
Antimutagens and Carcinogen-Blocking Agents
Isothiocyanates
Oltipraz
Other organosulfur compounds
Ellagic acid
Dehydroepiandrosterone (DHEA)
Antiproliferative Agents
Retinoids and [Beta]-carotene
Hormonal chemoprevention
Oral contraceptives
Gonadotropin-releasing hormone analogs (GNRHAs)
Hormone replacement therapy
Tamoxifen, Raloxifene, and aromatase inhibitors
Antiandrogens
Anti-inflammatory agents
Cyclooxygenase-2 inhibitors
Ornithine decarboxylase inhibitors
Antioxidants
Protease Inhibitors
Histone Deacetylase Inhibitors
Statins
Multiagent chemoprevention
Index

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