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| Introduction | |
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| Some Definitions | |
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| The Problem of Drug Abuse | |
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| Patterns and Development of Drug Use | |
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| Predictors of Initiation of Drug Abuse | |
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| Correlates of Cessation of Drug Use | |
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| Neurological Aspects of Drug Abuse | |
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| Tobacco and Nicotine | |
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| Tobacco Culture | |
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| Epidemiology and Patterns of Use | |
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| Pharmacokinetics and Pharmacodynamics | |
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| Effects of Nicotine | |
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| Subjective Effects | |
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| Physiological Dependence and Tolerance | |
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| Physiological Effects | |
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| Mechanism of Central Action | |
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| Morbidity and Mortality | |
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| Coronary Heart Disease | |
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| Cancer | |
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| Chronic Obstructive Pulmonary Disease | |
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| Smoking and Fetal Development | |
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| Passive Smoking | |
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| Treatment of Nicotine Addiction | |
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| Opioids | |
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| Culture and History | |
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| Opioid Drugs | |
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| Patterns of Use | |
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| Effects of Opioid Drugs | |
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| Subjective Effects | |
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| Analgesia | |
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| Gastrointestinal System | |
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| Respiration | |
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| In Utero Effects | |
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| Physiological Dependence | |
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| Tolerance | |
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| Mechanism of Action | |
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| Absorption and Fate | |
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| Toxicity | |
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| Pharmacological Treatment of Abuse | |
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| Depressants of the Central Nervous System: Alcohol, Barbiturates, and Benzodiazepines | |
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| Alcohol | |
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| Epidemiology and Patterns of Use | |
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| Genetics and Alcoholism | |
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| Central Nervous System Effects of Alcohol | |
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| Absorption, Distribution, and Metabolism | |
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| In Utero Effects of Alcohol | |
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| Beneficial Effects of Alcohol | |
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| Morbidity | |
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| Mortality | |
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| Pharmacological Treatment of Alcholism | |
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| Barbiturate and Nonbarbiturate Sedative-Hypnotics | |
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| Benzodiazepines and other Minor Tranquilizers | |
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| Effects of Benzodiazepines | |
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| Patterns of Use | |
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| Mechanism of Action | |
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| Tolerance and Physiological Dependence | |
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| Other Minor Tranquilizers | |
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| Depressants of the Central Nervous System: Volatile Solvents and Aerosols | |
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| Preparation Used | |
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| Patterns of Use | |
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| Effects of Volatile Solvents | |
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| Habitual Use of Volatile Solvents | |
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| Physiological Dependence | |
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| Toxic Effects of Volatile Solvents: Morbidity and Mortality | |
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| Aliphatic Hydrocarbons | |
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| Aromatic Hydrocarbons | |
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| Halogenated Hydrocarbons (Alkyl Halides) | |
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| Ketones | |
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| Esters | |
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| Nitrites | |
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| Club Drugs: Methylenedioxymethamphetamine (MDMA), Gamma Hydroxybutyrate (GHB), Ketamine, and Agents Taken in Similar Patterns | |
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| Methylenedioxymethamphetamine | |
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| Chemistry and Mechanism of Action | |
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| Effects and Toxicity | |
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| Patterns of Use | |
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| Metabolism | |
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| Gamma Hydroxybutyrate | |
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| Effects and Phamacokinetics | |
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| Dependence and Withdrawal | |
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| Medical Indications | |
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| Hallucinogens | |
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| Ketamine and Phencyclidine | |
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| Lysergic Acid Diethylamide | |
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| Marijuana and Hashish | |
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| Epidemiology and Patterns of Use | |
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| Pharmacokinetics and Pharmacodynamics | |
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| Physiological Dependence and Tolerance | |
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| Effects of Marijuana | |
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| Subjective Effects | |
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| Physiological Effects | |
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| Mechanism of Central Action | |
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| Adverse Effects | |
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| Acute Adverse Effects | |
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| Persistent Adverse Effects | |
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| Medical Use | |
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| Central Nervous System Stimulants: Cocaine, Amphetamines, Related Drugs, and Caffeine | |
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| Cocaine | |
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| Mechanism of Action, Absorption, and Fate | |
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| Toxicity | |
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| The Amphetamines | |
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| Neurotoxicity | |
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| Mechanism of Action, Absorption, and Fate | |
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| Effects of Amphetamine and Cocaine | |
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| Patterns of Use | |
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| Physiological Dependence on Stimulants | |
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| Khat Chewing and Cathinone | |
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| Caffeine and Theophylline | |
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| Patterns of Use | |
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| Effects | |
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| Physiological Dependence | |
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| Drugs Used to Treat Hyperactivity and Obesity | |
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| Medical Issues Associated with Drug Abuse | |
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| Infections Resulting from Intravenous Drug Use | |
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| Heart | |
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| Lung | |
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| Central Nervous System | |
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| Liver | |
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| Skin and Soft Tissue | |
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| Bone and Joint | |
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| Immune System | |
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| Pulmonary Health Risks from Smoking Illicit Drugs | |
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| Marijuana | |
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| Cocaine | |
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| Drug Abuse and the Law | |
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| Drug Abuse and American Federal Law | |
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| Drug Abuse and International Law | |
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| Index | |