Tissue Engineering Engineering Principles for the Design of Replacement Organs and Tissues

ISBN-10: 019514130X

ISBN-13: 9780195141306

Edition: 2004

Authors: W. Mark Saltzman

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Description:

Tissue engineering is a new field of biomedical engineering, in which synthetic materials are used together with biological components such as tissue fragments, cells, proteins to encourage tissue regeneration, regrowth, and repair. This book introduces the principles of tissue engineering in a unique way that is ideally suited for the modern engineering student. A review of developmental biology is presented early in the book, since biological development is the fundamental process of most relevance for tissue engineering. The study of development provides a pathway to basic bioengineering units on cell adhesion, migration, assembly, and transport, which are integrated in the final sections of the book into tissue engineering processes (such as cell delivery, growth factor administration, and polymeric scaffold materials).
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Book details

List price: $155.00
Copyright year: 2004
Publisher: Oxford University Press, Incorporated
Publication date: 7/15/2004
Binding: Hardcover
Pages: 544
Size: 6.25" wide x 9.25" long x 1.25" tall
Weight: 1.936
Language: English

W. Mark Saltzman is the Goizueta Foundation Professor of Chemical and Biomedical Engineering at Yale University. His research interests include materials for controlled drug delivery, drug delivery to the brain, and tissue engineering. He has taught at Johns Hopkins University and Cornell University and, after joining the Yale faculty in 2002, was named the first Chair of the Department of Biomedical Engineering. Professor Saltzman has published more than 150 research papers, 3 authored books, and 2 edited books, and he is an inventor on 10 patents. His many honors and awards include a Camille and Henry Dreyfus Foundation Teacher-Scholar Award (1990); the Allan C. Davis Medal as Maryland's Outstanding Young Engineer (1995); the Controlled Release Society Young Investigator Award (1996); Fellow of the American Institute of Biological and Medical Engineers (1997); the Professional Progress in Engineering Award from Iowa State University (2000); Britton Chance Distinguished Lecturer in Engineering and Medicine at the University of Pennsylvania (2000); and Distinguished Lecturer of the Biomedical Engineering Society (2004).

Tissue Exchange and Tissue Development
The State-of-the-Art in Tissue Exchange
History
Prospects for the Future
References
Objectives of Tissue Engineering
Tissue Engineering Is an Alternative to Drug Therapy, Gene Therapy, and Whole-Organ Transplantation
Tissue Engineering Attempts to Inspire or Control the Normal Processes of Tissue Repair and Healing
Tissue Engineering Attempts to Replace Cells that are Missing Within an Otherwise Functional Tissue or Organ
Tissue Engineering Uses Cellular Control Mechanisms to Enhance Drug Delivery
Tissue Engineering Leads to New Models of Human Physiology
Tissue Engineering
Summary
Exercises
References
Elements of Tissue Development
Early Transformations in the Embryo
Control of Development
Mechanisms of Development
Summary
Glossary
Exercises
References
Tissue Engineering Fundamentals
Cell Growth and Differentiation
The Cell Cycle
Stem Cells and Cell Differentiation
Agents that Regulate Cell Growth and Differentiation
Trafficking and Signal Transduction
Kinetics of Cell Proliferation
Summary
Exercises
References
Cell and Tissue Mechanics
Elementary Solid Mechanics
Elementary Fluid Mechanics
Mechanical Properties of Biological Fluids and Gels
Mechanical Properties of Cells
Mechanical Properties of Tissues
Summary
Exercises
References
Cell Adhesion
Mechanics of Cell Adhesion
Cell Junctions
Cell Adhesion Receptors
Extracellular Matrix
Cell Adhesion and Intracellular Signalling
Summary
Exercises
References
Cell Migration
Overview of Cell Migration
Experimental Observations on Cell Motility
Quantitative Methods for Describing the Movement of Individual Cells
Quantitative Methods for Describing the Movement of Cell Populations
Mean Time to Capture
Coordination of Cell Migration
Summary
Additional Information on Brownian Motion and Random Walks
Exercises
References
Cell Aggregation and Tissue Equivalents
Overview and Significance
Cell Aggregation and Cell Sorting
Models of Cell Aggregation
Cell-Populated Tissue Equivalents
Summary
Exercises
References
Tissue Barriers to Molecular and Cellular Transport
Mobility of Lipids and Proteins in the Membrane
Permeation of Molecules through Membranes
Permeation of Molecules through Cell Layers
Permeation of Cells through Cell Layers
Summary
Exercises
References
Tissue Engineering Practice
Cell Delivery and Recirculation
Cell Movement within the Circulatory System
Examples of Cell Trafficking between Body Compartments
Microchimerism
Cell Penetration into Three-Dimensional Tissues
Summary
Acknowledgment
Exercises
References
Delivery of Molecular Agents in Tissue Engineering
Technology for Controlled Delivery of Molecular Agents in Tissue Engineering
Controlled Release of Agents in Time and Space
Future Applications of Controlled Delivery in Tissue Engineering
Summary
Exercises
References
Cell Interactions With Polymers
Characterizing Cell Interactions with Polymers
Cell Interactions with Polymer Surfaces
Cell Interactions with Polymers in Suspension
Cell Interactions with Three-dimensional Polymer Scaffolds and Gels
Summary
Exercises
References
Approaches to Tissue Engineering
Artificial Organs
Roles of the Synthetic Component
Control of the Biological Component
Replacement of Tissue Structure or Function
Summary
Exercises
References
Case Studies in Tissue Engineering
Tissue-Engineered Cartilage
Tissue-Engineered Skin
Tissue-Engineering Approaches for Nerve Regeneration
References
Appendices
Introduction to Polymers
Polymer Properties
Non-degradable Polymers
Biodegradable Polymers
Water-Soluble Polymers
References
Analysis of Molecular Transport
Random Walks
Equations for the Diffusive Flux (Fick's Law)
Equations of Mass Conservation (Fick's Second Law)
Solutions to the Diffusion Equation with no Solute Elimination or Generation
References
Useful Data
Protein Properties
Blood and Tissue Cell Properties
Mathematical Tables and Functions
References
Nomenclature and Abbreviations
Nomenclature
Abbreviations
Glossary
Index
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