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Tissue Exchange and Tissue Development | |
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The State-of-the-Art in Tissue Exchange | |
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History | |
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Prospects for the Future | |
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References | |
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Objectives of Tissue Engineering | |
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Tissue Engineering Is an Alternative to Drug Therapy, Gene Therapy, and Whole-Organ Transplantation | |
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Tissue Engineering Attempts to Inspire or Control the Normal Processes of Tissue Repair and Healing | |
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Tissue Engineering Attempts to Replace Cells that are Missing Within an Otherwise Functional Tissue or Organ | |
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Tissue Engineering Uses Cellular Control Mechanisms to Enhance Drug Delivery | |
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Tissue Engineering Leads to New Models of Human Physiology | |
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Tissue Engineering | |
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Summary | |
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Exercises | |
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References | |
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Elements of Tissue Development | |
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Early Transformations in the Embryo | |
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Control of Development | |
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Mechanisms of Development | |
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Summary | |
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Glossary | |
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Exercises | |
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References | |
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Tissue Engineering Fundamentals | |
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Cell Growth and Differentiation | |
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The Cell Cycle | |
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Stem Cells and Cell Differentiation | |
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Agents that Regulate Cell Growth and Differentiation | |
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Trafficking and Signal Transduction | |
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Kinetics of Cell Proliferation | |
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Summary | |
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Exercises | |
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References | |
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Cell and Tissue Mechanics | |
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Elementary Solid Mechanics | |
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Elementary Fluid Mechanics | |
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Mechanical Properties of Biological Fluids and Gels | |
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Mechanical Properties of Cells | |
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Mechanical Properties of Tissues | |
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Summary | |
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Exercises | |
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References | |
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Cell Adhesion | |
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Mechanics of Cell Adhesion | |
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Cell Junctions | |
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Cell Adhesion Receptors | |
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Extracellular Matrix | |
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Cell Adhesion and Intracellular Signalling | |
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Summary | |
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Exercises | |
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References | |
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Cell Migration | |
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Overview of Cell Migration | |
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Experimental Observations on Cell Motility | |
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Quantitative Methods for Describing the Movement of Individual Cells | |
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Quantitative Methods for Describing the Movement of Cell Populations | |
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Mean Time to Capture | |
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Coordination of Cell Migration | |
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Summary | |
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Additional Information on Brownian Motion and Random Walks | |
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Exercises | |
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References | |
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Cell Aggregation and Tissue Equivalents | |
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Overview and Significance | |
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Cell Aggregation and Cell Sorting | |
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Models of Cell Aggregation | |
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Cell-Populated Tissue Equivalents | |
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Summary | |
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Exercises | |
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References | |
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Tissue Barriers to Molecular and Cellular Transport | |
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Mobility of Lipids and Proteins in the Membrane | |
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Permeation of Molecules through Membranes | |
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Permeation of Molecules through Cell Layers | |
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Permeation of Cells through Cell Layers | |
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Summary | |
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Exercises | |
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References | |
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Tissue Engineering Practice | |
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Cell Delivery and Recirculation | |
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Cell Movement within the Circulatory System | |
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Examples of Cell Trafficking between Body Compartments | |
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Microchimerism | |
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Cell Penetration into Three-Dimensional Tissues | |
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Summary | |
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Acknowledgment | |
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Exercises | |
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References | |
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Delivery of Molecular Agents in Tissue Engineering | |
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Technology for Controlled Delivery of Molecular Agents in Tissue Engineering | |
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Controlled Release of Agents in Time and Space | |
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Future Applications of Controlled Delivery in Tissue Engineering | |
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Summary | |
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Exercises | |
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References | |
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Cell Interactions With Polymers | |
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Characterizing Cell Interactions with Polymers | |
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Cell Interactions with Polymer Surfaces | |
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Cell Interactions with Polymers in Suspension | |
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Cell Interactions with Three-dimensional Polymer Scaffolds and Gels | |
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Summary | |
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Exercises | |
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References | |
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Approaches to Tissue Engineering | |
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Artificial Organs | |
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Roles of the Synthetic Component | |
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Control of the Biological Component | |
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Replacement of Tissue Structure or Function | |
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Summary | |
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Exercises | |
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References | |
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Case Studies in Tissue Engineering | |
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Tissue-Engineered Cartilage | |
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Tissue-Engineered Skin | |
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Tissue-Engineering Approaches for Nerve Regeneration | |
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References | |
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Appendices | |
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Introduction to Polymers | |
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Polymer Properties | |
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Non-degradable Polymers | |
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Biodegradable Polymers | |
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Water-Soluble Polymers | |
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References | |
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Analysis of Molecular Transport | |
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Random Walks | |
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Equations for the Diffusive Flux (Fick's Law) | |
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Equations of Mass Conservation (Fick's Second Law) | |
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Solutions to the Diffusion Equation with no Solute Elimination or Generation | |
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References | |
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Useful Data | |
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Protein Properties | |
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Blood and Tissue Cell Properties | |
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Mathematical Tables and Functions | |
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References | |
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Nomenclature and Abbreviations | |
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Nomenclature | |
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Abbreviations | |
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Glossary | |
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Index | |