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Research Methods in Occupational Epidemiology

ISBN-10: 0195092422
ISBN-13: 9780195092424
Edition: 2nd 2004 (Revised)
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Description: This widely used text provides a clear and critical summary of research approaches to the epidemiological study of workplace hazards. It describes the historical development of occupational epidemiology, methods for characterizing occupational  More...

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Book details

List price: $59.00
Edition: 2nd
Copyright year: 2004
Publisher: Oxford University Press, Incorporated
Publication date: 1/22/2004
Binding: Hardcover
Pages: 392
Size: 6.25" wide x 9.25" long x 1.00" tall
Weight: 1.540
Language: English

This widely used text provides a clear and critical summary of research approaches to the epidemiological study of workplace hazards. It describes the historical development of occupational epidemiology, methods for characterizing occupational exposures, and techniques for designing and implementing epidemiologic studies in this area. The relative strengths and limitations of various study designs for investigating specific health outcomes are emphasized. Also included are more advanced discussions of statistical analysis, exposure and dose modelling, and subsequent applications of data derived from epidemiologic research, as in meta-analysis, pooled analysis, and statistical analysis, exposure and dose modelling, and risk assessment. Since the first edition was published 15 years ago, there have been numerous advances in epidemiologic methods to accommodate a broadened scope of investigations of occupational exposures and associated adverse health outcomes. Thus, in this Second Edition the authors have updated their discussions of methodology to include such topics as case-cohort and case-crossover designs and statistical analysis of repeated measures data, and have expanded the examples they use throughout the book to demonstrate the applications of these methods to a wide range of acute and chronic health outcomes. They have also added a new chapter on occupational health surveillance. Their text is unique for its strong emphasis on the definition and assessment of exposures, the application of quantitative exposure data to epidemiologic models, and the recognition that improvements in workplace risk identification and quantification will come from careful integration of these approaches.

Thomas J. Smith, Professor of Industrial Hygiene, Harvard School of Public Health. David Kriebel, Professor of Work Environment, University of Lowell.

Introduction
Historical Background
The Scope of Occupational Epidemiology
Characterizing the Workplace Environment
General Concepts of Exposure and Dose
Approaches to Exposure Assessment
Reliability and Validity of Exposure Assessment
Combining Exposure Data from Multiple Sources
Overview of Study Designs
Case Series
Cohort Studies
Case-Control Studies
Proportionate Mortality Studies
Cross-sectional Studies
Connections between Study Designs
Precision and Validity in Study Design
Precision
Validity
Effect Modification and Estimation of Joint Effects
Cohort Studies
Basic Cohort Design
Methods of Data Analysis
Strategies of Analysis
Planning a Cohort Study
Case-Control Studies
Basic Study Design
Selection of Cases
Selection of Controls
Exposure Data
Data Analysis
Cross-sectional and Repeated Measures Studies
Study Design Features
Sources of Health and Exposure Data
Subject Selection Options
Methods of Data Analysis
Sources of Bias in Cross-sectional Studies
Planning Cross-sectional and Repeated Measures Studies
Occupational Health Surveillance
Defining Surveillance
Selecting Health Outcomes for Surveillance
Surveillance Study Designs
Surveillance in Defined Occupational Cohorts
Surveillance in the General Population
Advanced Statistical Analysis
Continuous Outcome Data
Dichotomous Outcome Data
Model Specification
Exposure and Dose Modeling
The Starting Point: The Exposure Profile
Summary Measures of Exposure
Understanding the Exposure-Dose Relation
Is Dose the Right Metric?
The Dosimetric Model
Incorporating Inter-individual Variability into Dose Metrics
Exposure Weighting
Induction Time Analysis
Multistage Cancer Model
Choosing the Best Measure of Exposure or Dose
Strengths and Limitations of Dose Modeling
Special Applications of Occupational Epidemiology
Meta-Analysis
Data Pooling
Risk Assessment
Index

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