x

Our Privacy Policy has changed. By using this site, you agree to the Privacy Policy.

Drug Delivery Engineering Principles for Drug Therapy

ISBN-10: 0195085892
ISBN-13: 9780195085891
Edition: 2001
Authors: W. Mark Saltzman
List price: $125.00 Buy it from $84.47
This item qualifies for FREE shipping

*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost® and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace" orders are not eligible for free or discounted shipping.

30 day, 100% satisfaction guarantee

If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.

Learn more about our returns policy

Description: Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those  More...

New Starting from $96.69
what's this?
Rush Rewards U
Members Receive:
coins
coins
You have reached 400 XP and carrot coins. That is the daily max!

Study Briefs

Limited time offer: Get the first one free! (?)

All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.

Add to cart
Study Briefs
Periodic Table Online content $4.95 $1.99
Add to cart
Study Briefs
Calculus 1 Online content $4.95 $1.99
Add to cart
Study Briefs
Medical Terminology Online content $4.95 $1.99

Customers also bought

Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading

Book details

List price: $125.00
Copyright year: 2001
Publisher: Oxford University Press, Incorporated
Publication date: 3/15/2001
Binding: Hardcover
Pages: 384
Size: 6.25" wide x 9.25" long x 0.75" tall
Weight: 0.110
Language: English

Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.

W. Mark Saltzman is the Goizueta Foundation Professor of Chemical and Biomedical Engineering at Yale University. His research interests include materials for controlled drug delivery, drug delivery to the brain, and tissue engineering. He has taught at Johns Hopkins University and Cornell University and, after joining the Yale faculty in 2002, was named the first Chair of the Department of Biomedical Engineering. Professor Saltzman has published more than 150 research papers, 3 authored books, and 2 edited books, and he is an inventor on 10 patents. His many honors and awards include a Camille and Henry Dreyfus Foundation Teacher-Scholar Award (1990); the Allan C. Davis Medal as Maryland's Outstanding Young Engineer (1995); the Controlled Release Society Young Investigator Award (1996); Fellow of the American Institute of Biological and Medical Engineers (1997); the Professional Progress in Engineering Award from Iowa State University (2000); Britton Chance Distinguished Lecturer in Engineering and Medicine at the University of Pennsylvania (2000); and Distinguished Lecturer of the Biomedical Engineering Society (2004).

Introductory material
Introduction
Historical perspective
The aim and structure of this book
Drug administration and drug effectiveness
The state of the art
Two views of the future
Summary
Fundamentals
Diffusion and drug dispersion
Random walks
Equations for the diffusive flux (Fick's law)
Equations of mass conservation (Fick's second law)
Solutions to the diffusion equation with no solute elimination or generation
Solutions to the diffusion equation with solute binding and elimination
A few applications
Summary
Diffusion in biological systems
Measurement of diffusion coefficients
Diffusion in water
Diffusion in polymer solutions and gels
Diffusion in the extracellular space
Diffusion with binding in tissues
Diffusion within cells
Diffusion and reaction
Summary
Drug permeation through biological barriers
Mobility of lipids and proteins in the membrane
Permeation through lipid membranes
Permeation through porous membranes
Permeation is enhanced by membrane proteins
Permeation through cell layers
Summary
Drug transport by fluid motion
Blood movement in the circulatory system
Interstitial fluid movement
Fluid movement in the lymphatic circulation
Fluid movement in the brain
Summary
Pharmacokinetics of drug distribution
Compartmental models
Physiological models
Patterns of mixing in tissues and organs
The problem of scale
Summary
Drug delivery systems
Drug modification
Enhancing agent solubility
Enhancing agent stability
Regulating agent permeability
Drug targeting and drug valency
Summary
Controlled drug delivery systems
Reservoir and transdermal delivery systems
Matrix delivery systems
Hydrogel delivery systems
Degradable delivery systems
Particulate delivery systems
Responsive delivery systems
Summary
Case studies in drug delivery
Controlled delivery of systemic therapy
Implants for local drug delivery
Topically applied devices for controlled release
Postscript
Overview of polymeric biomaterials
Non-degradable polymers
Silicone elastomers
Poly[ethylene-co-(vinyl acetate)]
Polyurethanes
Other important polymers
Biodegradable polymers
Polyesters
Copolymers of methyl vinyl ether and maleic anhydride
Poly(ortho esters)
Polyanhydrides
Poly(amino acids)
Phosphorus-containing polymers
Polycarbonates and poly(iminocarbonates)
Polydioxanone
Water-soluble polymers
Naturally occurring polymers
Acrylates and acrylamides
Poly(ethylene glycol)
Useful data and nomenclature
Physiological parameters
Cardiovascular system
Clinical chemistry
Permeation and diffusion
Protein properties
Mathematical tables and functions
Nomenclature
Index

×
Free shipping on orders over $35*

*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost® and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace" orders are not eligible for free or discounted shipping.

Learn more about the TextbookRush Marketplace.

×