Neuropathology of Schizophrenia Progress and Interpretation

Name: Neuropathology of Schizophrenia Progress and Interpretation
Price: 47.02 USD
Availability: InStock
ISBN: 9780192629074

ISBN-10: 0192629077

ISBN-13: 9780192629074

Edition: 2000

Authors: Paul J. Harrison, Gareth Roberts

List price: $160.00

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The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview of this rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology, arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature thought to be central to understanding the pathology. This is followed by critical appraisal of the various interpretations placed upon these…

Book details

List price: $160.00
Copyright year: 2000
Publisher: Oxford University Press, Incorporated
Publication date: 10/26/2000
Binding: Hardcover
Pages: 386
Size: 6.61" wide x 9.45" long x 0.98" tall
Weight: 1.936
Language: English

Paul J. Harrison is Professor Emeritus in the Department of Earth and Ocean Sciences at the University of British Columbia, Vancouver, Canada. He is an expert in nutrient ecophysiology of seaweeds and phytoplankton, with over 40 years of research experience.

Gareth Roberts was born in Chesham, Buckinghamshire in 1968. His scripts for Doctor Who on television include 'The Shakespeare Code' (2007), 'The Unicorn And The Wasp' (2008), 'The Lodger' (2010) and 'Closing Time' (2011), and he has also written many scripts for the spin-off series The Sarah Jane Adventures, as well as scripts for programmes as diverse as Emmerdale and Randall and Hopkirk (Deceased). He has written nine original Doctor Who novels, and lives in West London.



List of contributors


Introduction



Structural Imaging Findings and Macroscopic Pathology



In vivo brain imaging in schizophrenia


Brain morphology in schizophrenia


Global versus regional changes


Structural abnormalities as part of a neural network


Timing and progression of structural abnormalities


Diagnostic specificity of the findings


Conclusions and future directions



Hippocampal Pathology



Neuroanatomy of the normal hippocampal formation


Gross morphometry of the hippocampal formation in schizophrenia


Hippocampal cytoarchitecture and neuronal morphometry in schizophrenia


Cognitive impairment, dementia, and investigations of neurodegeneration in schizophrenia


Regional specificity of hippocampal neuropathological findings


Concluding remarks



Cortical Pathology: a New Generation of Quantitative Microscopic Studies



Stereomorphometric studies


The cortical GABA system


The cortical glutamate system


The cortical dopamine system


Cortical pathology and the neurodevelopmental hypothesis


Conclusions



Synaptic Pathology



Assessment of synapses


Models of synaptic abnormalities in schizophrenia


Studies of synapses in schizophrenia


Discussion and conclusions



Gliosis and its Implications for the Disease Process



Glia and gliosis


Gliosis in schizophrenia


The meaning of an absence of gliosis


Conclusions



Cerebral Asymmetry



Structural cerebral asymmetries


Cerebral asymmetry in schizophrenia


Conclusions



Functional Imaging and Neural Circuitry in Schizophrenia



Applied neuroimaging and the neuropathology of schizophrenia


Functional imaging techniques


Functional imaging and neurocircuitry


Corticothalamocerebellar circuitry and cognitive dysmetria in schizophrenia


Summary and conclusion



Neuropathology and the Neurodevelopmental Model



Evidence supporting a neurodevelopmental origin of schizophrenia


Evidence against schizophrenia as a neurodegenerative disorder


Neuropathological findings and the neurodevelopmental model


Limitations of the neurodevelopmental model



Cortical Development and Schizophrenia



Molecular basis for the organisation of the forebrain


Pattern formation and its functional consequences


Fate determination


Concluding remarks



The Organization of Cortical Circuitry



A model system for circuitry analysis: the primate dorsolateral prefrontal cortex


Cortical neuron types


Laminar arrangement of neurons


Organization of efferent projections


Organization and termination of afferent projections


Vulnerable prefrontal cortex circuitry in schizophrenia



Perspectives from other Diseases and Lesions



Neuropathology and diagnostic issues


Diseases sharing non-specific pathological features with schizophrenia


Disorders in which schizophrenia-like symptoms may occur


Normal determinants of neuronal parmeters and the effects of experimental lesions


Suggestions for future studies



Animal Models of Schizophrenia



Modeling schizophrenia in animals: some general considerations


Neurodevelopmental animal models of schizophrenia


Future approaches to modeling schizophrenia in animals



A Sceptical View of the Neuropathology of Schizophrenia



Overall brain dimensions


Lateral ventricular enlargement


Regional cerebral volumes


Temporal lobe limbic structures


Other brain structures


Histological findings


Conclusions



Methodological Issues



Methodological issues in case collection and selection


Methodological issues for studies of neurochemical pathology


Methodological issues for morphometric studies



Neuropathological Consequences of Schizophrenia Treatments



Neuropathological effects of antipsychotic drugs


Neuropathological effects of other treatments


Neuropathological effects of substance misuse


Conclusions


Index