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Prion Diseases of Humans and Animals

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ISBN-10: 0137203276

ISBN-13: 9780137203277

Edition: 1992

Authors: Stanley B. Prusiner

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Book details

Copyright year: 1992
Publisher: Ellis Horwood Limited
Binding: Hardcover
Pages: 500
Size: 7.25" wide x 9.75" long x 1.25" tall
Weight: 2.838
Language: English

Preface
Acknowledgement
An introduction to prion research
Terminology of prion diseases
A sideways look at the scrapie saga: 1732-1991
The search for the scrapie agent: 1961-1981
Photo- and radiobiology of the scrapie agent
The scrapie-kuru connection: recollection of how it came about
Kuru and scrapie
Spongiform encephalopathies - slow, latent, and temperate virus infections - in retrospect
Prion diseases from a neuropathologist's perspective
Reflections and highlights: a life with kuru
Fieldwork in the South Fore: the process of ethnographic inquiry
Molecular genetics of inherited, sporadic and iatrogenic prion disease
Genetic and transgenic studies of prion proteins in Gerstmann-Straussler-Scheinker disease
Prion protein gene analysis and transmission studies of Creutzfeldt-Jakob disease
The molecular genetics of human transmissible spongiform encephalopathy
Indiana variant of Gerstmann-Straussler-Scheinker disease
Inherited prion disease in Libyan Jews
Fatal familial insomnia: a prion disease with a mutation in codon 178 of the prion protein gene - study of two kindreds
Creutzfeldt-Jakob disease epidemiology
Familial dementia in relation to the 144 bp insert and its implications
Prion disease: the spectrum of pathology and diagnostic considerations
Bovine spongiform encephalopathy: a brief epidemiography, 1985-1991
The discovery of bovine spongiform encephalopathy and observations on the vacuolar changes
Association of ovine PrP protein variants with the Sip gene and their similarity to bovine PrP protein
Bovine spongiform encephalopathy: the history, scientific, political and social issues
Transmissible mink encephalopathy
The lymphoreticular system in the pathogenesis of scrapie
Association of PrP gene polymorphisms with the incidence of natural scrapie in British sheep
PrP gene allelic variants and natural scrapie in French Ile-de-France and Romanov sheep
Nucleic acids and scrapie prions
Modified host nucleic acids: a role in scrapie infection?
Cataloguing post-translational modifications of the scrapie prion protein by mass spectrometry
Glycosylinositol phospholipid anchors of prion proteins
Interaction of the prion protein with cellular proteins
Molecular cloning and structural analysis of a candidate chicken prion protein
Dissecting the pathway of scrapie prion synthesis in cultured cells
Effects of scrapie infection on cellular PrP metabolism
Modification and expression of prion proteins in cultured cells
Transgenic approaches to experimental and natural prion diseases
Scrapie prion protein accumulation correlates with neuropathology and incubation times in hamsters and transgenic mice
The basis of strain variation in scrapie
The genetics of prion susceptibility in the mouse
How can the 'protein only' hypothesis of prion propagation be reconciled with the existence of multiple prion strains?
Prion biology
Prions and neurodegenerative diseases