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Editors and Lead Contributors | |
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Preface | |
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Biomaterials Science: A Multidisciplinary Endeavor | |
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A History of Biomaterials | |
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Materials Science and Engineering | |
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Properties of Materials | |
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Introduction | |
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Bulk Properties of Materials | |
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Finite Element Analysis | |
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Surface Properties and Surface Characterization of Materials | |
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Role of Water in Biomaterials | |
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Classes of Materials Used in Medicine | |
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Introduction | |
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Polymers | |
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Silicone Biomaterials: History and Chemistry | |
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Medical Fibers and Biotextiles | |
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Hydrogels | |
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Applications of "Smart Polymers" as Biomaterials | |
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Bioresorbable and Bioerodible Materials | |
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Natural Materials | |
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Metals | |
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Ceramics, Glasses, and Glass-Ceramics | |
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Pyrolytic Carbon for Long-Term Medical Implants | |
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Composites | |
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Nonfouling Surfaces | |
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Physicochemical Surface Modification of Materials Used in Medicine | |
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Textured and Porous Materials | |
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Surface-Immobilized Biomolecules | |
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Biology, Biochemistry, and Medicine | |
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Some Background Concepts | |
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Background Concepts | |
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The Role of Adsorbed Proteins in Tissue Response to Biomaterials | |
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Cells and Cell Injury | |
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Tissues, the Extracellular Matrix, and Cell-Biomaterial Interactions | |
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Mechanical Forces on Cells | |
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Host Reactions to Biomaterials and Their Evaluation | |
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Introduction | |
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Inflammation, Wound Healing, and the Foreign-Body Response | |
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Innate and Adaptive Immunity: The Immune Response to Foreign Materials | |
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The Complement System | |
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Systemic Toxicity and Hypersensitivity | |
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Blood Coagulation and Blood-Materials Interactions | |
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Tumorigenesis and Biomaterials | |
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Biofilms, Biomaterials, and Device-Related Infections | |
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Biological Testing of Biomaterials | |
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Introduction to Testing Biomaterials | |
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In Vitro Assessment of Tissue Compatibility | |
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In Vivo Assessment of Tissue Compatibility | |
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Evaluation of Blood-Materials Interactions | |
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Large Animal Models in Cardiac and Vascular Biomaterials Research and Testing | |
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Microscopy for Biomaterials Science | |
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Degradation of Materials in the Biological Environment | |
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Introduction: Degradation of Materials in the Biological Environment | |
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Chemical and Biochemical Degradation of Polymers | |
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Degradative Effects of the Biological Environment on Metals and Ceramics | |
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Pathological Calcification of Biomaterials | |
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Application of Materials in Medicine, Biology, and Artificial Organs | |
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Introduction | |
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Nonthrombogenic Treatments and Strategies | |
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Cardiovascular Medical Devices | |
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Implantable Cardiac Assist Devices | |
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Artificial Red Blood Cell Substitutes | |
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Extracorporeal Artificial Organs | |
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Orthopedic Applications | |
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Dental Implantation | |
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Adhesives and Sealants | |
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Ophthalmological Applications | |
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Intraocular Lens Implants: A Scientific Perspective | |
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Burn Dressings and Skin Substitutes | |
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Sutures | |
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Drug Delivery Systems | |
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Bioelectrodes | |
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Cochlear Prostheses | |
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Biomedical Sensors and Biosensors | |
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Diagnostics and Biomaterials | |
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Medical Applications of Silicones | |
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Tissue Engineering | |
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Introduction | |
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Overview of Tissue Engineering | |
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Immunoisolation | |
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Synthetic Bioresorbable Polymer Scaffolds | |
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Practical Aspects of Biomaterials | |
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Implants, Devices, and Biomaterials: Issues Unique to this Field | |
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Introduction | |
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Sterilization of Implants and Devices | |
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Implant and Device Failure | |
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Correlation, Surfaces and Biomaterials Science | |
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Implant Retrieval and Evaluation | |
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New Products and Standards | |
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Introduction | |
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Voluntary Consensus Standards | |
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Development and Regulation of Medical Products Using Biomaterials | |
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Ethical Issues in the Development of New Biomaterials | |
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Legal Aspects of Biomaterials | |
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Perspectives and Possibilities in Biomaterials Science | |
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Properties of Biological Fluids | |
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Properties of Soft Materials | |
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Chemical Compositions of Metals Used for Implants | |
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The Biomaterials Literature | |
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Index | |