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| Contributors | |
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| Ontogeny and Functional Specialization of Dendritic Cells in Human and Mouse | |
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| Introduction | |
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| History of DC Identification and Characterization | |
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| Recent Advances in Mouse DC Immunobiology: Lessons from a Rodent | |
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| Recent Advances in Human DC Immunobiology | |
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| Humanized Mice | |
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| Matching Mice and Men | |
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| The Relationship of DCs to Monocytes and Macrophages | |
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| Next Steps Ahead | |
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| Disclosure Statement | |
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| Acknowledgments | |
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| References | |
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| Dendritic Cell Migration Through the Lymphatic Vasculature to Lymph Nodes | |
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| Structure and Function of the Lymphatic Vasculature | |
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| DC Migration into Lymphatics and the Requirement for Specialized Lymphatic Capillaries | |
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| DC Mobilization to LNs: The Role of CCR7 | |
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| DC Mobilization to LNs: The Machinery for Locomotion | |
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| Lymphangiogenesis and DC Trafficking During Inflammation | |
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| Concluding Remarks | |
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| References | |
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| A Close Encounter of the Third Kind: Monocyte-Derived Ceils | |
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| Dendritic Cell and Macrophages | |
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| Monocytes, the Mononuclear Phagocytes of the Blood Compartment | |
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| Monocytes, as Precursors of Tissue Mononuclear Phagocytes | |
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| Monocyte-Derived Cells in the Inflamed Peritoneum | |
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| Monocyte-Derived Cells in the Inflamed Brain | |
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| Monocyte-Derived Cells in the Intestine | |
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| Development of Monocyte-Derived Cells | |
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| Perspective | |
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| Acknowledgments | |
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| References | |
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| Plasmacytoid Dendritic Cell Development | |
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| Background | |
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| Markers for pDC Identification | |
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| Cytokines Promoting pDC Development | |
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| Transcription Factors Determining pDC Development | |
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| Early Investigation of the Myeloid Versus Lymphoid Origin of pDC | |
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| Markers of pDC of Lymphoid Origin? | |
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| CDP and the Consensus Myeloid Pathway to pDC | |
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| Reassessment of the Lymphoid Pathway to pDC | |
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| Implications of RAG-1 Expression and IgH Gene Rearrangements in pDC | |
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| Extension of the CDP Definition to Include New pDC Precursors | |
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| A Different Non-pDC but pDC-Like Product of the Myeloid Pathway | |
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| Tracking pDC Development Using Cellular "Barcoding" | |
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| Some Conclusions | |
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| References | |
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| Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases | |
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| The Mononuclear Phagocyte System | |
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| The DC Lineage | |
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| Origin and Regulation of DC Differentiation | |
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| DC Heterogeneity | |
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| Batf-IRF8-ID2-Dependent DC Lineage | |
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| Batf3-ID2-IRF8-lndependent DC Lineage | |
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| Monocyte-Derived DCs and Inflammatory DCs | |
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| The LC Exception | |
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| The Human DC Lineage | |
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| Human Histiocytoses as a Result of Dysregulated Differentiation of the Human Myeloid Compartment | |
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| Conclusion and Perspective | |
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| Acknowledg ments | |
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| References | |
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| Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity | |
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| Introduction | |
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| Activation, Priming, and Tolerance as Adaptive Responses of Macrophages | |
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| Polarized Activation | |
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| Molecular Mechanisms Underlying Macrophage Polarization | |
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| Epigenetic Regulation of Macrophage Polarization | |
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| Posttanscriptional Regulation in Macrophage Activation and Polarization | |
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| Concluding Remarks | |
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| Acknowledgments | |
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| References | |
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| Terminal Differentiation of Dendritic Cells | |
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| Introduction | |
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| Dendritic Cell Subsets | |
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| Transcriptional Regulation of Early DC Development: Cellular Differentiation and Some of the Key Regulatory Molecules | |
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| Transcriptional Regulation of Late DC Development at Steady State | |
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| Alternative DC Generation: Emergency Hematopoiesis | |
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| Perspectives | |
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| Acknowledgments | |
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| References | |
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| Diversity of Pathogen Sensors in Dendritic Cells | |
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| Introduction | |
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| Diversity of Pathogen Sensors in DCs | |
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| Interactions and Effectors | |
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| Perspectives | |
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| Acknowledgments | |
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| References | |
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| Transcriptional Control of Dendritic Cell Development | |
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| Dendritic Cells Comprise Functionally Heterogeneous Subsets | |
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| DC Development | |
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| Zbtb46 and cDCs | |
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| Ongoing Issues in DC Development | |
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| Acknowledgments | |
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| References | |
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| Transcriptional Control of Macrophage Identity, Self-Renewal, and Function | |
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| Creating Macrophage Identity | |
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| Controlling Macrophage Numbers and Proliferation | |
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| Transcriptional Control of Macrophage Specialization and Functional Activation States | |
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| Concluding Remarks | |
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| Acknowledgments | |
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| References | |
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| Index | |
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| Contents of Recent Volumes | |