Rabies Scientific Basis of the Disease and Its Management

ISBN-10: 0123965470

ISBN-13: 9780123965479

Edition: 3rd 2013

Authors: Alan C. Jackson

List price: $95.00
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Description:

Rabies remains one of the most important global public health problems worldwide. Although many important developments have been made over the past century to combat this ancient disease, rabies has become a re-emergent infection in the developing world. The third edition updates this classic reference with comprehensive coverage of the molecular virology, pathogenesis, vaccines, public health, immunology, and epidemiology of rabies. Chapters new to this edition cover biothreat/bioterrorism, successful wildlife control and therapies of human rabies, and the emergence of new lyssavirus species Rabies provides physicians, public health advisors, epidemiologists, research scientists and veterinarians with single source, authoritative and up-to-date information on the diagnosis, treatment, control and prevention of this fatal infectious virus which continues to kill over 70,000 people a year. No other book covers rabies in the breadth and depth offered in this completely updated volume.The chapter authors include research scientists who are distinguished experts on their topics.Includes abundant illustrations, many in color, to show this disease's unique horror.
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Book details

List price: $95.00
Edition: 3rd
Copyright year: 2013
Publisher: Elsevier Science & Technology
Publication date: 5/21/2013
Binding: Hardcover
Pages: 704
Size: 6.50" wide x 9.50" long x 1.75" tall
Weight: 3.630
Language: English

Preface
Foreword
List of Contributors
History of Rabies Research
Ancient Greek and Roman times
Girolamo Fracastoro
John Morgagni
Earliest Pathogenesis Studies
Louis Pasteur and Rabies Vaccination
Earliest Pathogenesis Studies Focused on Pathways of Neural Spread to CNS
Adelchi Negri and Negri bodies
Paul Remlinger
Early Studies Using Electron Microscopy
Fluorescent Antibody Staining by Goldwasser and Kissling
Pathogenesis Studies in Rodents by Richard T. Johnson and Frederick A. Murphy and Co-workers
First Clone of a Rabies Virus Gene
References
Rabies Virus
Introduction
Rabies Virus Architecture
Genome and RNP Structures
Life Cycle of Rabies Virus Infection
References
Epidemiology
Introduction
Global Epidemiology
Routes Of Rabies Virus Transmission
Risk and Prevention of Rabies Following an Exposure
Epidemiology of Human Rabies in North America and Europe
Epidemiology of Human Rabies in Africa and Asia
The Burden and Cost of Rabies in Africa and Asia
Epizootiology of Rabies in Latin America
Case Number Dynamics and Modeling
Skunk Rabies Virus Variants
Raccoon Rabies in North America
Epidemiology of Mongoose-associated Rabies
Canine Rabies Virus Variants
Conclusions
References
Molecular Epidemiology
Introduction
Methods and Definition of Terms
Lyssavirus Taxonomy
Future Trends
Conclusions
Acknowledgements
References
Rabies in Terrestrial Animals
Introduction
What is a Susceptible Host?
Pathogenesis
Prevention
Clinical Signs
Domestic Dogs
Raccoons
Skunks
Mongooses and Their Allies
Foxes
Coyotes
Jackals
Wolves
Cats
Cattle
Horses and Donkeys
Sheep and Goats
Opossums and Other Marsupials
Rodents and Lagomorphs
Other Species
Conclusions
References
Bat Rabies
Introduction
Lyssaviruses and Insectivorous Bats
Lyssaviruses and Frugivorous Bats
Rabies in Hematophagous Bats
Conclusions
Acknowledgements
References
Human Disease
Introduction
Exposures, Incubation Period, and Prodromal Symptoms
Clinical Forms of Disease
Investigations
Differential Diagnosis
Rabies Due to Other Lyssavirus Genotypes
References
Pathogenesis
Introduction
Virus Entry into the Nervous System
Rabies Virus Receptors
Spread to the CNS
Spread within the CNS
Spread from the CNS
Animal Models of Rabies Virus Neurovirulence
Structural Damage Caused by Rabies Virus Infection in the CNS
Brain Dysfunction in Rabies
Recovery from Rabies and Chronic Rabies Virus Infection
Summary
References
Pathology
Introduction
Macroscopic Findings
Pathology in the Central Nervous System
Pathology in the Peripheral Nervous System
Pathology Involving the Inoculation Site, Eye, and Extraneural Organs
Summary and Conclusions
References
Immunology
Introduction
RABV Innate Immune Response
RABV Adaptive Immune Response
RABV Infection Triggers a CNS Mediated Immune-Unresponsiveness
Paradoxical Role of IFN in RABV Virulence
Conclusions
References
Laboratory Diagnosis of Rabies
Laboratory-Based Rabies Diagnostic Testing
Postmortem Diagnosis of Rabies in Animals
Antemortem Diagnosis of Rabies
Use of Molecular Methods to Detect Viral RNA
Conclusions
References
Measures of Rabies Immunity
Introduction
History of Regulatory Standards
Regulatory Requirements
Assuring Quality Results
Assay Selection
Serum Neutralization Assays
Binding Assays
Defining "Adequate" or "Minimum" Response to Rabies Vaccination
Conclusions
References
Rabies Vaccines
Introduction
Human and Animal Rabies Vaccines
Acknowledgements
References
Next Generation of Rabies Vaccines
Introduction
History of Rabies Vaccines
Current Rabies Vaccine Regimens
Incidence and Risk for Rabies and Vaccine Failures
Correlates of Protection
Experimental Vaccines for Rabies
Summary
References
Public Health Management of Humans at Risk
Introduction
Human Deaths are Preventable
Factors Responsible for the Continuation of Human Rabies Deaths
Tools to Prevent Human Rabies Deaths
Communication, Awareness, and Advocacy
Involving Communities in Rabies Control Efforts
Sustainability
Conclusions
References
Therapy of Human Rabies
Human Cases with Recovery from Rabies
Future Prospects for the Aggressive Management of Rabies in Humans
References
Dog Rabies and Its Control
Introduction
Epidemiological Theory of Dog Rabies Control
Practical Aspects of Dog Rabies Control
References
Rabies Control in Wild Carnivores
Introduction
Historical and Contemporary Aspects of Rabies Control in Wildlife
The Concept of Controlling Rabies in Wildlife
Initiation of Wildlife Rabies Control Programs
Diagnosis of Suspect Wildlife
Vector Species Biology in Relation to Rabies Epidemiology
Transportation of Wildlife
Point Infection Control
Percentage of a Vector Population that has to be Culled or Immunized in order to Control Rabies
Bait Development for Delivery of Oral Rabies Vaccine
Oral Rabies Vaccination Initiation/Considerations
Importance of Rabies Vector Ecology for Rabies Control Planning
Large-Scale Vaccine-Bait Distribution Technology
Surveillance Prior to, During, and After a Rabies Control Program
The Ontario Rabies Management Program-A Model of a Multi-Faceted Approach to Wildlife Rabies Control
The Costs and Benefits of Wildlife Rabies Control
Vaccine Baiting Efficiency and Baiting Success Guidelines
Modeling
Contingency Planning
Conclusions
Acknowledgements
References
Blueprint for Rabies Prevention and Control
Introduction
Principles and Format
Steps Required for Canine Rabies Elimination
Conclusions and Future Developments
Acknowledgements
References
Future Developments and Challenges
Introduction
Pathogenesis
Epidemiology
Therapy of Human Rabies
Rabies Virus as a Biothreat Agent
Prevention of Human Rabies
Control of Animal Rabies
References
Index
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