Genetics of Bone Biology and Skeletal Disease

Name: Genetics of Bone Biology and Skeletal Disease
Price: 138.14 USD
Availability: InStock
ISBN: 9780123878298

ISBN-10: 0123878292

ISBN-13: 9780123878298

Edition: 2013

Authors: Rajesh V. Thakker, Michael P. Whyte, John Eisman, Takashi Igarashi

List price: $149.95

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Description:

Bone disorders are common and represent a major burden on health economic costs. Our understanding of bone development has had tremendous advances in the last ten year due primarily to focusing on genetics. For example, osteoporosis and related fractures are the leading cause of hospital admission in women over the age of 50 years, and 80% of adults over 55 years of age will suffer from osteoarthritis. Treatments of some metabolic disorders have been greatly improved by an increased understanding of bone biology which has been facilitated by advances in unravelling the genetics underlying bone disorders. These interactions between bone biology / physiology and genetics have also greatly…

Book details

List price: $149.95
Copyright year: 2013
Publisher: Elsevier Science & Technology
Publication date: 12/11/2012
Binding: Hardcover
Pages: 634
Size: 8.46" wide x 10.87" long x 1.50" tall
Weight: 4.444




General Background to Genetics


Overview of Basic Genetics


Genome-wide Association Studies (GWAS)


Functional Genomics & Molecular Pathology


Animal Models


Diagnostic Genetics


Genetic Counselling



General background to bone biology


Overview of Bone Structure and Bone Biology


Endocrine Regulation of Bone


Overview of Joint and Cartilage Biology


Translation / Treatment Principles


Pharmacogenomics and Gene Therapy


Osteoporosis - GWAS genes


Osteoporosis - Monogenic


Disorders Associated with High Bone Mass (Sclerosteosis and Van Buchem's Disease)


Osteoarthritis - GWAS genes


Osteoarthritis - Monogenic forms


Paget's disease (including familial expansile osteolysis, expansite skeletal hyperphosphatasia and juvenile Paget's disease)


Osteogenesis Imperfecta


Skeletal dysplasias


Hypophosphatasia


Fibrodysplasia (myosits) ossiforms progressiva


Tumoural calcinosis


Osteopetrosis



Parathyroid and related disorders


Hyperparathyroidism


Hypoparathyroidism


Pseudohypoparathyroidism


Disorders of the calcium-sensing receptor


Disorders of the PTH receptor


Multiple Endocrine Neoplasia



Vitamin D and renal disorders


Phosphate wasting disorders


FGF23 and Renal Bone Disease


Vitamin D dependent rickets type I and II


Renal fanconi syndromes


Dent's disease


Bartter's syndrome


Magnessium disorders


Hypercalciuria



Systemic diseases with bone involvement


Energy homeostasis and neuronal regulation of bone remodeling


Neuropeptide Y and Bone Regulation


Autoimmune disorders


Primary and secondary malignancies