Biomarkers of Neurological and Psychiatric Disease

ISBN-10: 0123877180

ISBN-13: 9780123877185

Edition: 2011

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Description: Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia.Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

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Book details

List price: $225.00
Copyright year: 2011
Publisher: Elsevier Science & Technology Books
Publication date: 11/9/2011
Binding: Hardcover
Pages: 470
Size: 6.00" wide x 9.00" long x 0.75" tall
Weight: 1.232
Language: English

Contributors
Preface
General Overview: Biomarkers in Neuroscience Research
The Quest for Biomarkers in Neuroscience
Tools for Biomarker Discovery in Neuroscience
Advancements in Biomarker Discovery in Neuroscience
Considerations for Biomarker Discovery and Translation in Neuroscience
Outlook-The Perspective of Personalized Medicine
Acknowledgments
References
Imaging Brain Microglial Activation Using Positron Emission Tomography and Translocator Protein-Specific Radioligands
Introduction
Principles of PET Imaging
TSPO for Assessment of Microglial Expression
Challenges Facing PET Imaging of the TSPO
Disease Applications
Conclusion
Acknowledgments
References
The Utility of Gene Expression in Blood Cells for Diagnosing Neuropsychiatric Disorders
Introduction
Microarray Gene Expression Analysis
Diagnostic Gene Expression Classifiers
Blood Gene Expression Studies of Neuropsychiatric Disorders
MicroRNA Expression Analysis
Pharmacogenomics
Concluding Remarks
Acknowledgments
References
Proteomic Technologies for Biomarker Studies in Psychiatry: Advances and Needs
Introduction
The Social Impact of Psychiatric Disorders
The Role of Proteomics in Psychiatry
Proteomic Studies in Psychiatry: What Methods Have Been Used to Date?
Underexplored Proteomic Methods in Psychiatry Studies
The Importance of Validation Experiments in Proteomics for Biomarker Discovery in Psychiatry
Clinical Translation
Summary
Acknowledgments
References
Converging Evidence of Blood-Based Biomarkers for Schizophrenia: An update
Introduction
Methodology
Results
Discussion
Conclusion and Perspectives
Acknowledgments
References
Abnormalities in Metabolism and Hypothalamic-Pituitary-Adrenal Axis Function in Schizophrenia
Introduction
Peripheral Metabolic Effects
Altered Hormone Secretion in Schizophrenia
Altered Hormone Production in Schizophrenia Pituitaries
Evidence for Altered Insulin Signaling in Schizophrenia Brain
Environmental Causes of Psychiatric Illness
Specificity of Molecular Signature for Schizophrenia
Therapeutic Implications
Special Considerations
Conclusions
Acknowledgments
References
Immune and Neuroimmune Alterations in Mood Disorders and Schizophrenia
Introduction
Inflammatory Cytokines in Psychiatric Disorders-State of the Art 2010
Circulating Immune Cells in Psychiatric Disorders-State of the Art 2010
Our Recent Studies on the Inflammatory State in Bipolar Disorder and Schizophrenia
Communication of Immune System and Brain in Psychiatric Illness: The Role of Microglia
The Origin of the Activated Immune System in Psychiatric Patients: Genes or Environment?
Conclusions
Acknowledgments
References
Behavioral and Molecular Biomarkers in Translational Animal Models for Neuropsychiatric Disorders
Introduction: The Problems with Animal Models
Toward Etiological Models in Neuropsychiatry
Reverse Translation
Statistical Methods to Link Biomarkers from Animal Models with the Human Disease
Integration of Animal Models Using the Framework of RDoC
Acknowledgments
References
Stem Cell Models for Biomarker Discovery in Brain Disease
Introduction
Need for Cellular Models
Understanding Disease
Biomarker Discovery
Accessible Cells for Biomarker Discovery in Brain Diseases
Patient-Derived Stem Cells for Biomarker Discovery in Brain Diseases
Olfactory Mucosa-An Accessible Neural Tissue for Biomarker Discovery
Patient-Derived Olfactory Stem Cells as Models for Brain Diseases
Patient-Derived Pluripotent Stem Cells as Models for Brain Diseases
Advantages and Disadvantages of Current Cell Models
Future Directions: Biomarkers from Stem Cell Models
Acknowledgments
References
The Application of Multiplexed Assay Systems for Molecular Diagnostics
Introduction
The Problem of Disease Heterogeneity
Multiplexed Assays are Needed to Characterize Heterogeneous Illnesses
Multiplex Immunoassay Profiling
Toward Functional Analysis
Conclusion and Outlook
Acknowledgments
References
Algorithm Development for Diagnostic Biomarker Assays
Introduction
Methods
Results and Discussion
Conclusions
Acknowledgments
References
Challenges of Introducing New Biomarker Products for Neuropsychiatry Disorders into the Market
Introduction
Biomarker Blood Tests for Diagnosis and Management of Mental Disorders
Current Dilemmas in Psychiatric Diagnosis
The Potential for Biomarker-Based Diagnostic Tests in Psychiatry
Why Is Early Diagnosis So Important?
Historical Perspective-The Blood of the "Insane"
Biomarkers: Not Quite Living up to the Promise?
Biomarkers: What Are the Issues?
Development of a Molecular Blood Test for Schizophrenia
Conclusions
Acknowledgments
References
Toward Personalized Medicine in the Neuropsychiatric Field
Introduction
Is Personalized Medicine All About Genetics? How Many Measures Are We Talking About?
Opportunities for Personalized Medicine in Neuropsychiatry for Drug Discovery
Conclusion
Acknowledgments
References
Clinical Utility of Serum Biomarkers for Major Psychiatric Disorders
Introduction and Scope of the Subject
About the Concept of Diagnosis in (Current) Psychiatry
What Should/Might a Useful Biomarker Predict/Distinguish in Psychiatry
Intermezzo: Lessons from Oncology
Overview of Current Results on Serum Biomarkers
Future Prospects, Research Agenda
Acknowledgments
References
Biomarkers, Biosensors, Neuroinformatics, and E-Neuropsychiatry and E-Neuropsychiatry
Introduction
Current Diagnostic Tools for Mental Illness
The Emergence of Molecular Biomarkers
Clinical Impact of Biomarkers
Point-of-Care Testing
Biosensors
Biosensors in Neuroscience
Neuroinformatics
e-Neuroscience and e-Neuropsychiatry
Acknowledgments
References
Subject Index
Contents of Recent Volumes
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