Basic Neurochemistry Principles of Molecular, Cellular, and Medical Neurobiology

ISBN-10: 0123749476
ISBN-13: 9780123749475
Edition: 8th 2012
List price: $125.00 Buy it from $82.50
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Description: This is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later  More...

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Book details

List price: $125.00
Edition: 8th
Copyright year: 2012
Publisher: Elsevier Science & Technology Books
Publication date: 12/7/2011
Binding: Hardcover
Pages: 1120
Size: 8.75" wide x 11.06" long x 1.50" tall
Weight: 5.896
Language: English

This is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions). This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists.* Includes clinical perspective boxes in each chapter that make connections between molecular processes and disease states, between biochemistry and drug discovery enabling students to better understand neurological diseases * Presents cutting-edge advances in neuroscience in context of principles of brain chemistry and biology * Companion Web site features animations to illustrate critical biochemical processes

OBITUARY FOR R. WAYNE ALBERS, August 5, 1928 - September 28, 2013 R. Wayne Albers, Ph.D., Scientist Emeritus, Chief of Section on Enzyme Chemistry (retired), Laboratory of Neurochemistry in the NINDS, NIH, Bethesda, MD, is a world-recognized neuroscientist most noted for his research in the field of membrane cation transport and neuronal excitability in the nervous system. Dr. Albers and physiologist R.L. Post performed the principal experiments leading to their now widely-held Albers-Post model for the mechanism of the cation transport enzyme, sodium-potassium-activated ATPase. Dr. Albers was one of the founding co-editors of the comprehensive text, Basic Neurochemistry: Molecular, Cellular and Medical Aspects, first published in 1972, continuing as co-editor for 8 editions, the latest having been published in 2012. After receiving his PhD at Washington University School of Medicine in 1954, Dr. Albers embarked on a distinguished career of research at the NIH, being a founding investigator in the first Laboratory of Neurochemistry. Dr. Albers was one of the first members of the American Society for Neurochemistry at its inception, serving on its Council and its Committees on Publications and Education and on Electronic Publications. He has served as Professor of Biochemistry at George Washington University, Faculty Member of the NIH Foundation for Advanced Education in the Sciences, Associate Editor of the Journal of Neurochemistry and of Experimental Neurology, and on the editorial boards of several journals. Dr. Albers passed away on September 28, 2013. He was 85 years old and is survived by his former wife, Frances Albers, their children Gail Morrell, Belinda Caron and Patricia Steinhoff, 6 grandchildren, and 8 great-grandchildren. He also had a son, the late Jonathan Albers. Dr. Albers was considered a gentleman, an excellent scientific colleague with a keen intellect and friend by all who worked with him. He will be sorely missed, not only by his family, but also by the entire neurochemistry community. George J. Siegel October 1, 2

Cellular Neurochemistry and Neural Membranes
Cell Biology of the Nervous System Cell Membrane Structures and Functions Membrane Transport Electrical Excitability and Ion Channels
Lipids
The Cytoskeleton of Neurons and Glia
Intracellular Trafficking
Axonal Transport
Cell Adhesion Molecules
Myelin Structure and Biochemistry
Energy Metabolism of the Brain
Intercellular Signaling
Synaptic Transmission and Cellular Signaling: An Overview
Acetylcholine
Catecholamines
Serotonin
Histamine
Glutamate and Glutamate Receptors GABA
Purinergic Signaling
Peptides
Intracellular Signaling
G Proteins
Cyclic Nucleotides in the Nervous System
Phosphoinositides
Calcium
Serine and Threonine Phosphorylation
Tyrosine Phosphorylation
Transcription Factors in the Central Nervous System
Growth, Development and Differentiation
Development of the Nervous System Growth Factors
Stem Cells in the Nervous System
Formation and Maintenance of Myelin Axonal Growth in the Adult Mammalian Nervous System
Cell Injury and Inflammation
Molecular Mechanisms and Consequences of Immune and Nervous System Reactions Neuroinflammation Brain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke Injury Lipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor
Apoptosis and Necrosis
Inherited and Neurodegenerative Diseases
Peripheral Neuropathy
Diseases Involving Myelin
The Epilepsies: Phenotypes and Mechanisms
Genetics of Neurodegenerative Diseases
Disorders of Amino Acid Metabolism
Inborn Metabolic Defects of Lysosomes, Peroxisomes, Carbohydrates, and Fatty Acids and Mitochondria Disorders of Muscle Excitability
Motor Neuron Diseases
Neurobiology of Alzheimer's Disease
Synucleinopathies and Tauopathies
Cellular and Molecular Basis of Neurodegeneration in the CAG-Polyglutamine Repeat Diseases Neurotransmitters and Disorders of the Basal Ganglia
Molecular Basis of Prion Diseases
Sensory Transduction
Molecular Biology of Vision
Molecular Biology of Olfaction and Taste
Molecular Biology of Hearing and Balance
Pain
Neural Processing and Behavior
Endocrine Effects on the Brain and Their Relationship to Behavior
Learning and Memory
The Neurochemistry of Sleep and Wakefulness The Neurochemistry of Schizophrenia
The Neurochemistry of Autism Neurobiology of Severe Mood and Anxiety Disorders
Addiction

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