Signal Transduction

ISBN-10: 0123694418
ISBN-13: 9780123694416
Edition: 2nd 2009
List price: $97.95
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Description: Signal Transduction, 2e Bastien D. Gomperts University College, London, United Kingdom Ijsbrand M. Kramer University of Bordeaux, Talence, France Peter E.R. Tatham University College, London, United Kingdom Miranda Gomperts KEY FEATURES: *  More...

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Book details

List price: $97.95
Edition: 2nd
Copyright year: 2009
Publisher: Elsevier Science & Technology Books
Publication date: 9/10/2015
Binding: Hardcover
Pages: 840
Size: 7.75" wide x 10.00" long x 1.75" tall
Weight: 4.290
Language: English

Signal Transduction, 2e Bastien D. Gomperts University College, London, United Kingdom Ijsbrand M. Kramer University of Bordeaux, Talence, France Peter E.R. Tatham University College, London, United Kingdom Miranda Gomperts KEY FEATURES: * Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention * In-depth coverage of nuclear receptors, including steps in isolation of steriod hormones and the discovery of intracellular hormone receptors; Tyrosine protein kinases and adaptive immunity; and intracellular calcium * Extensive conceptual colour artwork to assist with comprehension of key topics * Instrumental margin notes highlight milestones in signalling mechanisms DESCRIPTION: Signal Transduction is a thorough, well-illustrated study in cellular signaling processes. Beginning with the basics, this book shows how cells respond to external cues, hormones, growth factors, cytokines, cell surfaces, etc., and further instructs how these inputs are integrated. Instruction continues with up-to-date, inclusive coverage of intracellular calcium, nuclear receptors, tyrosine protein kinases and adaptive immunity, and targeting transduction pathways for research and medical intervention. Signal Transduction serves as an invaluable resource for advanced undergraduates, graduate researchers, and established scientists working in cell biology, pharmacology, immunology, and related fields. RELATED TITLES: Latchman: EUKARYOTIC TRANSCRIPTION FACTORS, 3E (1998; ISBN: 0-12-437176-0;62.95) * Up-to-date, inclusive coverage of targeting transduction pathways for research and medical intervention * In-depth coverage of nuclear receptors, including steps in isolation of steroid hormones and the discovery of intracellular hormone receptors; tyrosine protein kinases and adaptive immunity; and intracellular calcium * Extensive conceptual color artwork to assist with comprehension of key topics * Instrumental margin notes highlight milestones in signaling mechanisms

Prologue: Signal Transduction, origins and ancestors
First messengers
Receptors
GTP-binding proteins and signal transduction
Effector enzymes coupled to GTP binding proteins: adenylyl cyclase and phospholipase C
The regulation of visual transduction and olfaction
Intracellular calcium
Calcium effectors
Phosphorylation and dephosphorylation: protein kinases A and C
Nuclear receptors
Growth Factors: setting the framework
Signalling pathways operated by receptor protein tyrosine kinases
Signal transduction to and from adhesion molecules
Adhesion molecules in the regulation of cell differentiation: Mainly about Wnt
Activation of the innate immune system: the Toll-like receptor 4 and Signalling through Ubiquitylation
Traffic of white blood cells
Tyrosine protein kinases and adaptive immunity : TCR, BCR, soluble tyrosine kinases and NFAT
Phosphoinositide 3 kinases, protein kinase B and signalling through the insulin receptor
Protein Kinase C revisited
Signalling through receptor serine/threonine kinases
Protein dephosphorylation and protein phosphorylation
Notch
Targeting transduction pathways for research and medical intervention
Protein domains and signal transduction

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