| |
| |
| Contents by Subject Area | |
| |
| |
| Contributors | |
| |
| |
| Foreword | |
| |
| |
| Preface | |
| |
| |
| Guide to the Use of the Encyclopedia | |
| |
| |
| Acute Lymphoblastic Leukemia in Adults | |
| |
| |
| |
| Acute Lymphoblastic Leukemia in Children | |
| |
| |
| |
| Acute Myelocytic Leukemia | |
| |
| |
| |
| Adeno-Associated Virus: A Vector for High-Efficiency Gene Transduction | |
| |
| |
| |
| Akylating Agents | |
| |
| |
| |
| ALL-1 | |
| |
| |
| |
| Animal Models for Colon Cancer Chemoprevention | |
| |
| |
| |
| Anthracyclines | |
| |
| |
| |
| Antibodies in the Gene Therapy of Cancer | |
| |
| |
| |
| Antibody-Toxin and Growth Factor-Toxin Fusion Proteins | |
| |
| |
| |
| Anti-idiotypic Antibody Vaccines | |
| |
| |
| |
| Antioxidants: Carcinogenic and Chemopreventive Properties | |
| |
| |
| |
| Antisense: Medicinal Chemistry | |
| |
| |
| |
| Antisense Nucleic Acids: Clinical Applications | |
| |
| |
| |
| Antisense: Progress toward Gene-Directed Cancer Therapy | |
| |
| |
| |
| Anti-Vascular Endothelial Growth Factor-Based Angiostatics | |
| |
| |
| |
| APC (Adenomatous Polyposis Coli) Tumor Suppressor | |
| |
| |
| |
| Ataxia Telangiectasia Syndrome | |
| |
| |
| |
| Autocrine and Paracrine Growth Mechanisms in Cancer Progression and Metastasis | |
| |
| |
| |
| Bcl-2 Family Proteins and the Dysregulation of Programmed Cell Death | |
| |
| |
| |
| BCR/ABL | |
| |
| |
| |
| Bladder Cancer: Assessment and Management | |
| |
| |
| |
| Bladder Cancer: Epidemiology | |
| |
| |
| |
| Bleomycin | |
| |
| |
| |
| Bone Tumors | |
| |
| |
| |
| Brachytherapy | |
| |
| |
| |
| Brain and Central Nervous System Cancer | |
| |
| |
| |
| Brain Cancer and Magnetic Resonance Spectroscopy | |
| |
| |
| |
| Brain Tumors: Epidemiology and Molecular and Cellular Abnormalities | |
| |
| |
| |
| Breast Cancer | |
| |
| |
| |
| Camptothecins | |
| |
| |
| |
| Cancer Risk Reduction (Diet/Smoking Cessation/Lifestyle Changes) | |
| |
| |
| |
| Cancer Vaccines: Gene Therapy and Dendritic Cell-Based Vaccines | |
| |
| |
| |
| Cancer Vaccines: Peptide- and Protein-Based Vaccines | |
| |
| |
| |
| Carbohydrate-Based Vaccines | |
| |
| |
| |
| Carcinogen-DNA Adducts | |
| |
| |
| |
| Carcinogenesis: Role of Active Oxygen and Nitrogen Species | |
| |
| |
| |
| Caspases in Programmed Cell Death | |
| |
| |
| |
| Cationic Lipid-Mediated Gene Therapy | |
| |
| |
| |
| Cell Cycle Checkpoints | |
| |
| |
| |
| Cell Cycle Control | |
| |
| |
| |
| Cell-Matrix Interactions | |
| |
| |
| |
| Cell-Mediated Immunity to Cancer | |
| |
| |
| |
| Cellular Responses to DNA Damage | |
| |
| |
| |
| Chemical Mutagenesis and Carcinogenesis | |
| |
| |
| |
| Chemoprevention, Pharmacology of | |
| |
| |
| |
| Chemoprevention Trials | |
| |
| |
| |
| Chemotherapy: Synergism and Antagonism | |
| |
| |
| |
| Chromosome Aberrations | |
| |
| |
| |
| Chronic Lymphocytic Leukemia | |
| |
| |
| |
| Chronic Myelogenous Leukemia: Etiology, Incidence, and Clincal Features | |
| |
| |
| |
| Chronic Myelogenous Leukemia: Prognosis and Current Status of Treatment | |
| |
| |
| |
| Cisplatin and Related Drugs | |
| |
| |
| |
| c-mos Protooncogene | |
| |
| |
| |
| c-myc Protooncogene | |
| |
| |
| |
| Colorectal Cancer: Epidemiology and Treatment | |
| |
| |
| |
| Colorectal Cancer: Molecular and Cellular Abnormalities | |
| |
| |
| |
| Corticosteroids | |
| |
| |
| |
| Cytokine Gene Therapy | |
| |
| |
| |
| Cytokines: Hematopoietic Growth Factors | |
| |
| |
| |
| Differentiation and Cancer: Basic Research | |
| |
| |
| |
| Differentiation and the Role of Differentiation Inducers in Cancer Treatment | |
| |
| |
| |
| DNA-Based Cancer Vaccines | |
| |
| |
| |
| DNA Damage, DNA Repair, and Mutagenesis | |
| |
| |
| |
| DNA Methylation and Cancer | |
| |
| |
| |
| DNA Tumor Viruses: Adenovirus | |
| |
| |
| |
| Dosimetry and Treatment Planning for Three-Dimensional Radiation Therapy | |
| |
| |
| |
| Drug Resistance: DNA Sequence Amplification | |
| |
| |
| |
| Endocrine Tumors | |
| |
| |
| |
| Endometrial Cancer | |
| |
| |
| |
| Epstein-Barr Virus and Associated Malignancies | |
| |
| |
| |
| Esophageal Cancer: Risk Factors and Somatic Genetics | |
| |
| |
| |
| Esophageal Cancer: Treatment | |
| |
| |
| |
| Estrogens and Antiestrogens | |
| |
| |
| |
| ETS Family of Transcription Factors | |
| |
| |
| |
| Ewing's Sarcoma (Ewing's Family Tumors) | |
| |
| |
| |
| EWS/ETS Fusion Genes | |
| |
| |
| |
| Extracellular Matrix and Matrix Receptors: Alterations during Tumor Progression | |
| |
| |
| |
| Folate Antagonists | |
| |
| |
| |
| fos Oncogene | |
| |
| |
| |
| Gastric Cancer: Epidemiology and Therapy | |
| |
| |
| |
| Gastric Cancer: Inherited Predisposition | |
| |
| |
| |
| Gene Therapy Vectors: Safety Considerations | |
| |
| |
| |
| Genetic Alterations in Brain Tumors | |
| |
| |
| |
| Genetic Basis for Quantitative and Qualitative Changes in Drug Targets | |
| |
| |
| |
| Genetic Predisposition to Prostate Cancer | |
| |
| |
| |
| Germ Cell Tumors | |
| |
| |
| |
| Glutathione Transferases | |
| |
| |
| |
| Glycoproteins and Glycosylation Changes in Cancer | |
| |
| |
| |
| Graft versus Leukemia and Graft versus Tumor Activity | |
| |
| |
| |
| Head and Neck Cancer | |
| |
| |
| |
| Hepatitis B Viruses | |
| |
| |
| |
| Hepatitis C Virus (HCV) | |
| |
| |
| |
| Hepatocellular Carcinoma (HCC) | |
| |
| |
| |
| Hereditary Colon Cancer and DNA Mismatch Repair | |
| |
| |
| |
| Hereditary Risk of Breast and Ovarian Cancer: BRCA1 and BRCA2 | |
| |
| |
| |
| Her2/neu | |
| |
| |
| |
| HIV (Human Immunodeficiency Virus) | |
| |
| |
| |
| Hormonal Carcinogenesis | |
| |
| |
| |
| Hormone Resistance in Prostate Cancer | |
| |
| |
| |
| Human T-Cell Leukemia/Lymphotropic Virus | |
| |
| |
| |
| Hyperthermia | |
| |
| |
| |
| Hypoxia and Drug Resistance | |
| |
| |
| |
| Immune Deficiency: Opportunistic Tumors | |
| |
| |
| |
| Insulin-like Growth Factors | |
| |
| |
| |
| Integrin Receptor Signaling Pathways | |
| |
| |
| |
| Integrin-Targeted Angiostatics | |
| |
| |
| |
| Interferons: Cellular and Molecular Biology of Their Actions | |
| |
| |
| |
| Interleukins | |
| |
| |
| |
| Jak/STAT Pathway | |
| |
| |
| |
| Kidney, Epidemiology | |
| |
| |
| |
| Kinase-Regulated Signal Transduction Pathways | |
| |
| |
| |
| L-Asparaginase | |
| |
| |
| |
| Late Effects of Radiation Therapy | |
| |
| |
| |
| Li-Fraumeni Syndrome | |
| |
| |
| |
| Liposome-Mediated Gene Therapy | |
| |
| |
| |
| Liver Cancer: Etiology and Prevention | |
| |
| |
| |
| Lung Cancer: Molecular and Cellular Abnormalities | |
| |
| |
| |
| Lung, Larynx, Oral Cavity, and Pharynx | |
| |
| |
| |
| Lymphoma, Hodgkin's Disease | |
| |
| |
| |
| Lymphoma, Non-Hodgkin's | |
| |
| |
| |
| Macrophages | |
| |
| |
| |
| Magnetic Resonance Spectroscopy and Magnetic Resonance Imaging, Introduction | |
| |
| |
| |
| Magnetic Resonance Spectroscopy of Cancer: Clinical Overview | |
| |
| |
| |
| Malignant Mesothelioma | |
| |
| |
| |
| MAP Kinase Modules in Signaling | |
| |
| |
| |
| Melanoma: Biology | |
| |
| |
| |
| Melanoma: Cellular and Molecular Abnormalities | |
| |
| |
| |
| Melanoma: Epidemiology | |
| |
| |
| |
| Metabolic Diagnosis of Prostate Cancer by Magnetic Resonance Spectroscopy | |
| |
| |
| |
| Mismatch Repair: Biochemistry and Genetics | |
| |
| |
| |
| Molecular Aspects of Radiation Biology | |
| |
| |
| |
| Molecular Basis for Tumor Immunity | |
| |
| |
| |
| Molecular Epidemiology and Cancer Risk | |
| |
| |
| |
| Molecular Mechanisms of Cancer Invasion | |
| |
| |
| |
| Monoclonal Antibodies: Leukemia and Lymphoma | |
| |
| |
| |
| Multidrug Resistance I: P-Glycoprotein | |
| |
| |
| |
| Multidrug Resistance II: MRP and Related Proteins | |
| |
| |
| |
| Multiple Myeloma | |
| |
| |
| |
| Multistage Carcinogenesis | |
| |
| |
| |
| myb | |
| |
| |
| |
| Neoplasms in Acquired Immunodeficiency Syndrome | |
| |
| |
| |
| Neoplasms of Unknown Primary Site | |
| |
| |
| |
| Neuroblastoma | |
| |
| |
| |
| nm23 Metastasis Suppressor Gene | |
| |
| |
| |
| Non-Hodgkin's Lymphoma and Multiple Myeloma: Incidence and Risk Factors | |
| |
| |
| |
| Nutritional Supplements and Diet as Chemoprevention Agents | |
| |
| |
| |
| Ovarian Cancer: Epidemiology | |
| |
| |
| |
| Ovarian Cancer: Molecular and Cellular Abnormalities | |
| |
| |
| |
| Pancreas and Periampullary Tumors | |
| |
| |
| |
| Pancreatic Cancer: Cellular and Molecular Mechanisms | |
| |
| |
| |
| Papillomaviruses | |
| |
| |
| |
| PAX3-FKHR and PAX7-FKHR Gene Fusions in Alveolar Rhabdomyosarcoma | |
| |
| |
| |
| Pediatric Cancers, Molecular Features | |
| |
| |
| |
| PET Imaging and Cancer | |
| |
| |
| |
| p53 Gene Therapy | |
| |
| |
| |
| P-Glycoprotein as a General Antiapoptotic Protein | |
| |
| |
| |
| Photodynamic Therapy: Basic Principles and Applications to Skin Cancer | |
| |
| |
| |
| Photodynamic Therapy: Clinical Applications | |
| |
| |
| |
| Prostate Cancer | |
| |
| |
| |
| Protein Kinase Inhibitors | |
| |
| |
| |
| Proton Beam Radiation Therapy | |
| |
| |
| |
| p16 and ARF: Crossroads of Tumorigenesis | |
| |
| |
| |
| PTEN | |
| |
| |
| |
| Purine Antimetabolites | |
| |
| |
| |
| Pyrimidine Antimetabolites | |
| |
| |
| |
| Pyruvate Kinases | |
| |
| |
| |
| Radiation Resistance | |
| |
| |
| |
| Radiobiology, Principles of | |
| |
| |
| |
| Radiolabeled Antibodies, Overview | |
| |
| |
| |
| Ras Proteins | |
| |
| |
| |
| Recombination: Mechanisms and Roles in Tumorigenesis | |
| |
| |
| |
| Renal Cell Cancer | |
| |
| |
| |
| Replication-Selective Viruses for Cancer Treatment | |
| |
| |
| |
| Resistance to Antibody Therapy | |
| |
| |
| |
| Resistance to DNA-Damaging Agents | |
| |
| |
| |
| Resistance to Inhibitor Compounds of Thymidylate Synthase | |
| |
| |
| |
| Resistance to Inhibitors of Dihydrofolate Reductase | |
| |
| |
| |
| Resistance to Topoisomerase-Targeting Agents | |
| |
| |
| |
| Retinoblastoma Tumor Suppressor Gene | |
| |
| |
| |
| Retroviral Vectors | |
| |
| |
| |
| Retroviruses | |
| |
| |
| |
| Rhabdomyosarcoma, Early Onset | |
| |
| |
| |
| Ribozymes and Their Applications | |
| |
| |
| |
| RUNX/CBF Transcription Factors | |
| |
| |
| |
| Sarcomas of Soft Tissue | |
| |
| |
| |
| Senescence, Cellular | |
| |
| |
| |
| Signal Transduction Mechanisms Initiated by Receptor Tyrosine Kinases | |
| |
| |
| |
| Skin Cancer, Non-Melanoma | |
| |
| |
| |
| STAT Proteins in Growth Control | |
| |
| |
| |
| Stem Cell Transplantation | |
| |
| |
| |
| Stereotactic Radiosurgery of Intracranial Neoplasms | |
| |
| |
| |
| Steroid Hormones and Hormone Receptors | |
| |
| |
| |
| Suicide Genes | |
| |
| |
| |
| Targeted Toxins | |
| |
| |
| |
| Targeted Vectors for Cancer Gene Therapy | |
| |
| |
| |
| Taxol and Other Molecules That Interact with Microtubules | |
| |
| |
| |
| T Cells against Tumors | |
| |
| |
| |
| T Cells and Their Effector Functions | |
| |
| |
| |
| Telomeres and Telomerase | |
| |
| |
| |
| Testicular Cancer | |
| |
| |
| |
| TGF[beta] Signaling Mechanisms | |
| |
| |
| |
| Thyroid Cancer | |
| |
| |
| |
| TLS-CHOP in Myxoid Liposarcoma | |
| |
| |
| |
| Tobacco Carcinogenesis | |
| |
| |
| |
| Total Body Irradiation | |
| |
| |
| |
| TP53 Tumor Suppressor Gene: Structure and Function | |
| |
| |
| |
| Transfer of Drug Resistance Genes to Hematopoietic Precursors | |
| |
| |
| |
| Transgenic Mice in Cancer Research | |
| |
| |
| |
| Tumor Antigens | |
| |
| |
| |
| Tumor Cell Motility and Invasion | |
| |
| |
| |
| Tumor Necrosis Factors | |
| |
| |
| |
| Tumor Suppressor Genes: Specific Classes | |
| |
| |
| |
| Vascular Targeting | |
| |
| |
| |
| Vinca Alkaloids and Epipodophyllotoxins | |
| |
| |
| |
| Viral Agents | |
| |
| |
| |
| Von Hippel-Lindau Disease | |
| |
| |
| |
| Wilms Tumor: Epidemiology | |
| |
| |
| |
| Wilms Tumor Suppressor WT1 | |
| |
| |
| |
| Wnt Signaling | |
| |
| |
| |
| Index | |