Retroviral Proteases

Name: Retroviral Proteases
Availability: OutOfStock
ISBN: 9780121821425

ISBN-10: 0121821420

ISBN-13: 9780121821425

Edition: 1994

Authors: John N. Abelson, Melvin I. Simon, Lawrence C. Kuo, Jules A. Shafer

List price: $72.95

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Description:

Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.

Book details

List price: $72.95
Copyright year: 1994
Publisher: Elsevier Science & Technology
Publication date: 11/7/1994
Binding: Hardcover
Pages: 432
Size: 5.94" wide x 9.00" long x 0.75" tall
Weight: 1.782
Language: English



Bacterial Expression and Enzymatic Assays



Expression Systems for Retroviral Proteases



Genetic Approaches Designed to Minimize Cytotoxicity of Retroviral Protease



Host Strain Selection for Bacterial Expression of Toxic Proteins



Assay Methods for Retroviral Proteases



Analysis of Human Immunodeficiency Virus 1 Protease Activity in Eukaryotic and Bacterial Cells



Synthetic Approaches to Continuous Assays of Retroviral Proteases


Purification and Characterization



Identification, Purification, and Cell Culture Assays of Retroviral Proteases



Stability of Dimeric Retroviral Proteases



Use of Steady State Kinetic Methods to Elucidate the Kinetic and Chemical Mechanisms of Retroviral Proteases



X-Ray Structures of Retroviral Proteases and Their Inhibitor-Bound Complexes



Probing Structure--Function Relationships in Human Immunodeficiency Virus 1 Protease via Molecular Dynamics Simulation



Relationships of Human Immunodeficiency Virus Protease with Eukaryotic Aspartic Proteases


Substrate Specificity and Inhibitor Design



Processing of Retroviral Gag Polyproteins: An in Vitro Approach



Subsite Preferences of Retroviral Proteinases



Specificity of Retroviral Proteases: An Analysis of Viral and Nonviral Protein Substrates



Rapid Determination of Endoprotease Specificity Using Peptide Mixtures and Edman Degradation Analysis



Design of Tight-Binding Human Immunodeficiency Virus Type 1 Protease Inhibitors



Design of Symmetry-Based, Peptidomimetic Inhibitors of Human Immunodeficiency Virus Protease



Advances in Automated Docking Applied to Human Immunodeficiency Virus Type 1 Protease



Use of Molecular Dynamics and Free Energy Pertubation Calculations in Anti- Human Immunodeficiency Virus Drug Design



Qualitative Study of Drug Resistance in Retroviral Protease Using Structural Modeling and Site-Directed Mutagenesis


Author Index


Subject Index