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| Contributors | |
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| Preface | |
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| Clinical Evaluation of the Patient | |
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| Initial Approach to the Patient: History and Physical Examination | |
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| Examination of Blood Cells | |
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| Examination of the Marrow, Daniel H. Ryan | |
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| the Organization of the Lymphohematopoietic Tissues | |
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| Structure of the Marrow and the Hematopoietic Microenvironment | |
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| The Organization and Structure of Lymphoid Tissues | |
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| Epochal Hematology | |
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| Hematology of the Fetus and Newborn | |
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| Hematology during Pregnancy | |
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| Hematology in Older Persons | |
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| Molecular and Cellular Hematology | |
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| Genetic Principles and Molecular Biology | |
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| Genomics and Epigenetics | |
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| Cytogenetics and Molecular Abnormalities | |
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| Apoptosis | |
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| Cell-Cycle Regulation and Hematologic Disorders | |
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| Signal Transduction Pathways | |
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| The Cluster of Differentiation Antigens | |
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| Hematopoietic Stem Cells | |
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| The Inflammatory Process | |
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| Innate Immunity | |
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| Dendritic Cells and the Control of Innate Adaptive Immunity | |
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| Therapeutic Principles | |
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| Pharmacology and Toxicity of Antineoplastic Drugs | |
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| Principles of Hematopoietic Cell Transplantation | |
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| Treatment of Infections in the Immunocompromised Host | |
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| Principles of Antithrombotic Therapy | |
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| Principles of Immune Cell Therapy | |
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| Principles of Vaccine Therapy | |
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| Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications | |
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| Principles of Gene Transfer for Therapy | |
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| Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement | |
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| The Erythrocyte | |
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| Morphology of the Erythron | |
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| Composition of the Erythrocyte, Ernest Beutler | |
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| Production of Erythrocytes | |
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| Destruction of Erythrocytes, Ernest Beutler | |
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| Clinical Manifestations and Classification of Erythrocyte Disorders | |
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| Aplastic Anemia: Acquired and Inherited | |
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| Pure Red Cell Aplasia | |
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| Anemia of Chronic Renal Disease | |
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| Anemia of Chronic Disease | |
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| Anemia of Endocrine Disorders | |
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| The Congenital Dyserythropoietic Anemias | |
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| Paroxysmal Nocturnal Hemoglobinuria | |
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| Folate, Cobalamin, and Megaloblastic Anemias | |
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| Disorders of Iron Metabolism, Ernest Beutler | |
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| Anemia Resulting from Other Nutritional Deficiencies | |
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| Anemia Associated with Marrow Infiltration | |
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| The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseaes | |
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| Disorders of Red Cells Resulting from Enzyme Abnormalities | |
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| The Thalassemias: Disorders of Globin Synthesis | |
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| Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities | |
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| Methemoglobinemia and Other Dyshemoglobinemias | |
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| Hemolytic Anemia Resulting from Physical Injury to Red Cells | |
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| Hemolytic Anemia Resulting from Chemical and Physical Agents | |
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| Hemolytic Anemia Resulting from Infections with Microorganisms | |
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| Hemolytic Anemia Resulting from Immune Injury | |
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| Alloimmune Hemolytic Disease of the Fetus and Newborn | |
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| Hypersplenism and Hyposlenism | |
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| Primary and Secondary Polycythemias (Erythrocytosis) | |
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| The Porphyrias | |
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| Hereditary and Acquired Sideroblastic Anemias | |
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| Neutrophils, Eosinophils, Basophils, and Mast Cells | |
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| Morphology of Neutrophils, Eosinophils, and Basophils | |
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| Composition of Neutrophils | |
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| Production, Distribution, and Fate of Neutrophils | |
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| Eosinophils and Their Disorders | |
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| Basophils and Mast Cells and Their Disorders | |
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| Classification and Clinical Manifestations of Neutrophil Disorders | |
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| Neutropenia and Neutrophilia | |
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| Disorders of Neutrophil Function | |
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| Monocytes and Macrophages | |
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| Morphology of Monocytes and Macrophages | |
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| Biochemistry and Functions of Monocytes and Macrophages | |
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| Production, Distribution, and Fate of Monocytes and Macrophages | |
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| Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages | |
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| Monocytosis and Monocytopenia | |
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| Inflammatory and Malignant Histiocytosis | |
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| Lipid Storage Diseases | |
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| Lymphocytes and Plasma Cells | |
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| Morphology of Lymphocytes and Plasma Cells | |
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| Composition and Biochemistry of Lymphocytes and Plasma Cells | |
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| Lymphopoiesis | |
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| Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production | |
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| Functions of T Lymphocytes: T-Cell Receptors for Antigen | |
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| Functions of Natural Killer Cells | |
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| Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders | |
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| Lymphocytosis and Lymphocytopenia | |
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| Immunodeficiency Diseases | |
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| Hematologic Manifestations of Acquired Immunodeficiency Syndrome | |
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| Mononucleosis Syndromes | |
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| Neoplastic Myeloid Diseases | |
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| Classification and Clinical Manifestations of the Clonal Myeloid Disorders | |
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| Polycythemia Vera | |
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| Essential Thrombocythemia | |
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| Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia) | |
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| Acute Myelogenous Leukemia | |
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| Chronic Myelogenous Leukemia and Related Disorders | |
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| Primary Myelofibrosis | |
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| Neoplastic Lymphoid Diseases | |
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| Classification of Malignant Lymphoid Disorders | |
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| Acute Lymphoblastic Leukemia | |
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| Chronic Lymphocytic Leukemia and Related Diseases | |
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| Hairy Cell Leukemia | |
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| Large Granular Lymphocytic Leukemia | |
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| General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodel Disease | |
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| Pathology of Malignant Lymphomas | |
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| Hodgkin Lymphoma | |
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| Diffuse Large B-Cell Lymphoma | |
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| Follicular Lymphoma | |
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| Mantle Cell Lymphoma | |
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| Marginal Zone B-Cell Lymphomas | |
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| Burkitt Lymphoma | |
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| Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome) | |
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| Mature T-Cell and Natural Killer Cell Lymphomas | |
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| Plasma Cell Neoplasms: General Considerations, H. Elizabeth Broome | |
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| Essential Monoclonal Gammopathy | |
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| Myeloma | |
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| The Amyloidoses | |
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| Macroglobulinemia | |
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| Heavy-Chain Disease | |
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| Hemostatis and Thrombosis | |
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| Megakaryopoiesis and Thrombopoiesis | |
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| Platelet Morphology, Biochemistry, and Function | |
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| Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostatis | |
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| Control of Coagulation Reactions | |
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| Vascular Function in Hemostatis | |
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| Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostatis | |
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| Thrombocytopenia | |
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| Reactive Thrombocytosis | |
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| Hereditary Qualitative Platelet Disorders | |
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| Acquired Qualitative Platelet Disorders | |
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| The Vascular Purpuras | |
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| Hemophilia a and Hemophilia B | |
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| Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors | |
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| Hereditary Fibrinogen Abnormalities | |
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| Von Willebrand Disease | |
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| Antibody-Mediated Coagulation Factor Deficiencies, Pete Lollar | |
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| Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation | |
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| Disseminated Intravascular Coagulation | |
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| Hereditary Thrombophilia | |
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| The Antiphospholipid Syndrome | |
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| Antibody-Mediated Thrombotic Disorders: Thrombotic-Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia | |
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| Venous Thrombosis | |
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| Atherothrombosis: Disease Initiation, Progression, and Treatment | |
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| Fibrinolysis and Thrombolysis | |
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| Transfusion Medicine | |
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| Erythrocyte Antigens and Antibodies | |
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| Human Leukocyte and Platelet Antigens | |
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| Blood Procurement and Screening | |
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| Red Cell Transfusion | |
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| Preservation and Clinical Use of Platelets | |
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| Index | |