Medical Literature A Manual for Evidence-Based Clinical Practice

ISBN-10: 007159034X

ISBN-13: 9780071590341

Edition: 2nd 2008

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Description: The #1 guide to the principles and clinical applications of evidence-based medicine has just gotten better! No other resource helps you to put key evidence-based medicine protocols into daily clinical practice better than "Users' Guides to the Medical Literature," An instant classic in its first edition, this detailed, yet highly readable reference demystifies the statistical, analytical, and clinical principles of evidence-based medicine, giving you a hands-on, practical resource that no other text can match. Here, you'll learn how to distinguish solid medical evidence from poor medical evidence, devise the best search strategies for each clinical question, critically appraise the medical literature, and optimally tailor evidence-based medicine for each patient. The new second edition of this landmark resource is now completely revised and refreshed throughout, with expanded coverage of both basic and advanced issues in using evidence-based medicine in clinical practice. FEATURES Completely revised and updated to reflect the enormous expansion in medical research and evidence-based resources since the first edition Innovative organization guides you from the fundamentals of using the medical literature to the more advanced strategies and skills for use in every day patient care situations Abundant and current real-world examples drawn from the medical literature are woven throughout, and include important related principles and pitfalls in using medical literature in patient care decisions Practical focus on the key issues in evidence-based practice: What are the results? Are the results valid? How to I apply to results to the care of my patients? Edited by over 60internationally recognized editors and contributors from the U.S., Canada, South America, Europe, and Asia-the best of the best in the discipline NEW, Current, authoritative content covering how to: Avoid being misled by biased presentations of research findings; Interpret the significance of clinical trials that are discontinued early; Influence clinician behavior to improve patient care; Apply key strategies for teaching evidence-based medicine; And more Also look for JAMAevidence.com, a new interactive database for the best practice of evidence based medicine.

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Book details

List price: $80.00
Edition: 2nd
Copyright year: 2008
Publisher: McGraw-Hill Professional Publishing
Publication date: 5/21/2008
Binding: Paperback
Pages: 860
Size: 6.00" wide x 9.00" long x 1.50" tall
Weight: 2.244
Language: English

Gordon Guyatt, MD, Deputy Editor, JAMA; Professor of Medicine, McMaster University, Hamilton, Ontario, Canada. Drummond Rennie, MD, Professor of Medicine, UCSF School of Medicine, San Francisco, CA Maureen Meade, MD, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Deborah Cook, MD, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Contributors
Foreword
Preface
The Foundations
How to Use the Medical Literature-and This Book-to Improve Your Patient Care
The Philosophy of Evidence-Based Medicine
What Is the Question?
Finding the Evidence
Why Study Results Mislead: Bias and Random Error
Therapy
Therapy (Randomized Trials)
Does Treatment Lower Risk? Understanding the Results
Confidence Intervals
Advanced Topics in the Validity of Therapy Trials
An Illustration of Bias and Random Error
Surprising Results of Randomized Trials
Randomized Trials Stopped Early for Benefit
The Principle of Intention to Treat
N-of-1 Randomized Controlled Trials
Clinical Decision Support Systems
Advanced Topics in the Results of Therapy Trials
Hypothesis Testing
Understanding the Results: More About Odds Ratios
What Determines the Width of the Confidence Interval?
Composite Endpoints
Measuring Patients' Experience
Advanced Topics in Applying the Results of Therapy Trials
Applying Results to Individual Patients
Example Numbers Needed to Treat
Dealing With Misleading Presentations of Clinical Trial Results
Surrogate Outcomes
Qualitative Research
Harm (Observational Studies)
Harm (Observational Studies)
Advanced Topics in Harm: Correlation and Regression
Diagnosis
The Process of Diagnosis
Differential Diagnosis
Diagnostic Tests
Advanced Topics in Diagnosis
Spectrum Bias
Examples of Likelihood Ratios
Measuring Agreement Beyond Chance
Clinical Prediction Rules
Prognosis
Prognosis
Summarizing the Evidence
Summarizing the Evidence
Advanced Topics in Systematic Reviews
Reporting Bias
Fixed-Effects and Random-Effects Models
Making Sense of Variability in Study Results
When to Believe a Subgroup Analysis
Moving From Evidence to Action
How to Use a Patient Management Recommendation
Advanced Topics in Moving From Evidence to Action
Economic Analysis
Decision Making and the Patient
Moving From Evidence to Action: Recommendations About Screening
Grading Recommendations
Drug Class Effects
Parallel but Separate Goals: Evidence-Based Practitioners and Evidence-Based Care
Changing Behavior to Apply Best Evidence in Practice
Teachers' Guides to the Users' Guides
Glossary
Index
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