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| Authors | |
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| Preface | |
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| Introduction to Endocrinology | |
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| The Endocrine System | |
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| Hormones: Endocrine, Paracrine, Autocrine, Juxtacrine, & Intracrine Actions | |
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| Endocrine Organs | |
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| Target Organs | |
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| Hormone Receptors | |
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| Chemical Composition of Hormones | |
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| Relationships between Hormones & Other Signaling Molecules | |
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| Neurotransmitters & Hormones | |
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| Vitamins & Hormones | |
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| Eicosanoids: Prostaglandins & Related Compounds | |
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| Metabolites | |
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| Oncogenes & Hormones | |
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| The Immune System & Hormones | |
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| Modulation of Hormone Levels | |
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| Regulation of Hormone Production | |
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| Molecular Mechanisms Regulating Hormone Release | |
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| Hormone Transport in the Circulation | |
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| Transport of Hormones across the Membrane | |
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| Metabolism & Elimination of Hormones | |
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| Mechanisms of Hormone Action | |
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| Hormone Receptors | |
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| Hormone Binding | |
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| Hormone Effects on Receptor Activity | |
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| Classes of Hormone Action | |
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| Classification of Hormone Action by Receptor Type | |
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| Classification of Hormone Action by Ligand Type | |
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| Regulation of Hormone Responsiveness | |
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| Regulation of Receptor Levels & Activities | |
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| Hormone Responsiveness Is Regulated by Postreceptor Influences | |
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| Combinatorial Interactions Influence Hormone Signaling in Different Ways | |
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| Selective Modulation | |
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| Evolution of the Endocrine System | |
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| The Origins of Regulatory Chemicals & the Metabolic Code | |
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| Evolution of Hormones & Receptors | |
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| Evolution of Multiple Hormone Response Systems | |
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| Evolution of Endocrine Glands | |
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| Integrative Networks | |
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| Endocrine & Nervous System Relationships: Neuroendocrinology | |
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| Actions of Hormones | |
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| Fetal Development | |
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| Cell Growth & Cancer | |
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| Intermediary Metabolism | |
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| Mineral & Water Metabolism | |
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| Cardiovascular & Renal Function | |
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| Skeletal Function | |
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| Reproductive Function | |
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| Immune System | |
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| Central Nervous System | |
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| Recent Advances in Technology & Endocrinology | |
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| Sequencing the Human Genome | |
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| Genomics & Patterns of Transcription | |
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| Proteomics | |
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| Manipulating the Genome | |
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| RNA Interference (RNAi) | |
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| Stem Cells | |
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| Molecular Basis of Genetic Endocrine Disease | |
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| Disorders of the Endocrine System | |
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| Endocrine Hypofunction | |
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| Endocrine Hyperfunction | |
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| Defects in Sensitivity to Hormones | |
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| Syndromes of Hormone Excess Due to Exogenous Hormone | |
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| Nonendocrine Problems Associated with Endocrine Disease | |
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| Approach to the Patient with Endocrine Disease | |
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| History & Physical Examination | |
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| Laboratory Studies | |
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| Screening for Endocrine Diseases | |
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| Treatment of Endocrine Diseases | |
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| Uses of Hormones & Selective Modulators in Therapy of Nonendocrine Disease | |
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| Mechanisms of Hormone Action | |
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| Receptors | |
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| Neurotransmitter & Peptide Hormone Receptors | |
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| G Protein-Coupled Receptors | |
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| G Protein Transducers | |
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| Effectors | |
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| Disorders of G Proteins and G Protein-Coupled Receptors | |
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| Growth Factor Receptors | |
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| Cytokine Receptors | |
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| Guanylyl Cyclase-Linked Receptors | |
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| Nuclear Action of Peptide Hormones | |
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| Nuclear Receptors | |
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| Steroid Receptor Family | |
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| Thyroid Receptor Family | |
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| Nongenomic Effects of the Steroid Hormones | |
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| Steroid & Thyroid Hormone Receptor Resistance Syndromes | |
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| Endocrine Autoimmunity | |
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| Basic Immune Components & Mechanisms | |
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| Immune Recognition & Response | |
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| Tolerance | |
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| Autoimmunity Is Multifactorial | |
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| Genetic Factors in Autoimmunity | |
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| Environmental Factors in Autoimmunity | |
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| Single Gland Autoimmune Syndromes | |
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| Autoimmune Aspects of Thyroid Disease | |
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| Autoimmune Aspects of Type 1 Diabetes | |
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| Autoimmune Aspects of Other Endocrinopathies | |
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| Autoimmune Polyglandular Syndromes | |
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| Autoimmune Polyglandular Syndrome I (APS-I) | |
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| Autoimmune Polyglandular Syndrome II (APS-II) | |
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| Management of Autoimmune Polyglandular Syndromes | |
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| Poems Syndrome (Osteosclerotic Myeloma) | |
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| Evidence-Based Endocrinology & Clinical Epidemiology | |
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| Clinical Epidemiology | |
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| Diagnostic Testing: Test Characteristics | |
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| An Approach to Diagnosis in Practice | |
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| Clinical Epidemiologic Principles Applied to Treatment Decisions | |
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| Decision Analysis | |
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| Other Aspects of Clinical Epidemiology | |
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| Evidence-Based Endocrinology | |
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| Translation of the Clinical Problem into Answerable Questions | |
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| Finding the Best Evidence | |
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| Appraising the Evidence for Its Validity & Usefulness | |
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| Applying the Results in Practice & Evaluating Performance | |
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| Hypothalamus & Pituitary Gland | |
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| Hypothalamic Hormones | |
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| Anterior Pituitary Hormones | |
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| Adrenocorticotropic Hormone & Related Peptides | |
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| Growth Hormone | |
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| Prolactin | |
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| Thyrotropin | |
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| Gonadotropins: Luteinizing Hormone & Follicle-Stimulating Hormone | |
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| Endocrinologic Evaluation of the Hypothalamic-Pituitary Axis | |
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| Evaluation of Adrenocorticotropic Hormone (ACTH) | |
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| Evaluation of Growth Hormone (GH) | |
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| Evaluation of Prolactin (PRL) | |
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| Evaluation of Thyroid-Stimulating Hormone (TSH) | |
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| Evaluation of LH & FSH | |
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| Problems in Evaluation of the Hypothalamic-Pituitary Axis | |
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| Effects of Pharmacologic Agents on Hypothalamic-Pituitary Function | |
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| Endocrine Tests of Hypothalamic-Pituitary Function | |
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| Neuroradiologic Evaluation | |
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| Pituitary & Hypothalamic Disorders | |
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| Empty Sella Syndrome | |
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| Hypothalamic Dysfunction | |
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| Hypopituitarism | |
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| Pituitary Adenomas | |
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| Posterior Pituitary (Neurohypophysis) | |
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| Review of Normal Anatomy & Physiology | |
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| Vasopressin Insufficiency: Diabetes Insipidus | |
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| Excess Vasopressin: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) | |
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| Oxytocin | |
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| Parturition | |
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| Lactation | |
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| Growth | |
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| Normal Growth | |
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| Intrauterine Growth | |
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| The Placenta | |
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| Classic Hormones of Growth & Fetal Growth | |
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| Growth Factors & Oncogenes in Fetal Growth | |
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| Insulin-Like Growth Factors, Receptors, & Binding Proteins | |
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| Insulin | |
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| Epidermal Growth Factor | |
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| Fetal Origins of Adult Disease | |
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| Postnatal Growth | |
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| Measurement of Growth | |
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| Skeletal (Bone) Age | |
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| Disorders of Growth | |
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| Short Stature Due to Nonendocrine Causes | |
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| Short Stature Due to Endocrine Disorders | |
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| Diagnosis of Short Stature | |
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| Tall Stature Due to Nonendocrine Causes | |
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| Tall Stature Due to Endocrine Disorders | |
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| The Thyroid Gland | |
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| Embryology, Anatomy, & Histology | |
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| Physiology | |
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| Structure & Synthesis of Thyroid Hormones | |
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| Iodine Metabolism | |
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| Thyroid Hormone Synthesis & Secretion | |
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| Abnormalities in Thyroid Hormone Synthesis & Release | |
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| Metabolism of Thyroid Hormones | |
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| Control of Thyroid Function & Hormone Action | |
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| Physiologic Changes in Thyroid Function | |
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| Thyroid Autoimmunity | |
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| Tests of Thyroid Function | |
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| Tests of Thyroid Hormones in Blood | |
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| Assessment of Thyroid Iodine Metabolism & Biosynthetic Activity | |
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| Thyroid Imaging | |
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| Thyroid Ultrasonography & Other Imaging Techniques | |
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| Thyroid Biopsy | |
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| Test of Peripheral Thyroid Hormone Actions | |
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| Measurement of Thyroid Autoantibodies | |
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| Disorders of the Thyroid | |
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| Hypothyroidism | |
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| Hyperthyroidism & Thyrotoxicosis | |
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| Thyroid Hormone Resistance Syndromes | |
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| Nontoxic Goiter | |
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| Thyroiditis | |
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| Effects of Ionizing Radiation on the Thyroid Gland | |
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| Thyroid Nodules & Thyroid Cancer | |
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| Metabolic Bone Disease | |
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| Cellular & Extracellular Calcium Metabolism | |
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| Parathyroid Hormone | |
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| Calcitonin | |
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| Vitamin D | |
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| How Vitamin D & PTH Control Mineral Homeostasis | |
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| Medullary Carcinoma of the Thyroid (MCT) | |
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| Hypercalcemia | |
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| Disorders Causing Hypercalcemia | |
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| Treatment of Hypercalcemia | |
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| Hypocalcemia | |
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| Causes of Hypocalcemia | |
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| Treatment of Hypocalcemia | |
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| Bone Anatomy & Remodeling | |
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| Functions of Bone | |
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| Structure of Bone | |
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| Bone Remodeling | |
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| Osteoporosis | |
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| Treatment of Osteoporosis | |
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| Glucocorticoid-Induced Osteoporosis | |
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| Osteomalacia & Rickets | |
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| Nephrotic Syndrome | |
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| Hepatic Osteodystrophy | |
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| Drug-Induced Osteomalacia | |
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| Hypophosphatemic Disorders | |
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| Calcium Deficiency | |
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| Primary Disorders of the Bone Matrix | |
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| Inhibitors of Mineralization | |
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| Paget's Disease of Bone (Osteitis Deformans) | |
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| Renal Osteodystrophy | |
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| Glucocorticoids & Adrenal Androgens | |
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| Embryology & Anatomy | |
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| Biosynthesis of Cortisol & Adrenal Androgens | |
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| Circulation of Cortisol & Adrenal Androgens | |
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| Metabolism of Cortisol & Adrenal Androgens | |
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| Biologic Effects of Adrenal Steroids | |
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| Glucocorticoids | |
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| Adrenal Androgens | |
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| Laboratory Evaluation | |
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| Disorders of Adrenocortical Insufficiency | |
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| Primary Adrenocortical Insufficiency (Addison's Disease) | |
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| Secondary Adrenocortical Insufficiency | |
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| Diagnosis of Adrenocortical Insufficiency | |
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| Treatment of Adrenocortical Insufficiency | |
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| Prognosis of Adrenocortical Insufficiency | |
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| Cushing's Syndrome | |
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| Hirsutism & Virilism | |
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| Incidental Adrenal Mass | |
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| Glucocorticoid Therapy for Nonendocrine Disorders | |
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| Endocrine Hypertension | |
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| Hypertension of Adrenal Origin | |
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| Synthesis, Metabolism, & Action of Mineralocorticoid Hormones | |
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| Pathogenesis of Mineralocorticoid Hypertension | |
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| Aldosterone & the Heart | |
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| Primary Aldosteronism | |
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| Syndromes Due to Excess Deoxycorticosterone Production | |
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| Cushing's Syndrome | |
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| Pseudohyperaldosteronism | |
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| Type II Pseudohypoaldosteronism (Arnold-Healy-Gordon Syndrome) | |
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| Hypertension of Renal Origin | |
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| The Renin-Angiotensin System | |
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| The Renin-Angiotensin System & Hypertension | |
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| Other Hormone Systems & Hypertension | |
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| Insulin | |
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| Natriuretic Peptides | |
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| Nitric Oxide | |
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| Endothelin | |
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| Kallikrein-Kinin System | |
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| Other Hormones & Autacoids | |
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| Sympathetic Nervous System | |
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| Adrenal Medulla & Paraganglia | |
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| History | |
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| Anatomy | |
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| Hormones of the Adrenal Medulla | |
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| Catecholamines | |
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| Other Hormones Secreted by the Adrenal Medulla | |
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| Disorders of Adrenal Medullary Function | |
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| Adrenal Medullary Hypofunction (Epinephrine Deficiency) | |
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| Adrenal Medullary Hyperfunction | |
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| Pheochromocytoma | |
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| Testes | |
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| Anatomy & Structure-Function Relationships | |
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| Testes | |
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| Accessory Structures | |
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| Physiology of the Male Reproductive System | |
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| Gonadal Steroids | |
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| Control of Testicular Function | |
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| Evaluation of Male Gonadal Function | |
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| Clinical Evaluation | |
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| Laboratory Tests of Testicular Function | |
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| Pharmacology of Drugs Used to Treat Male Gonadal Disorders | |
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| Androgens | |
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| Gonadotropins | |
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| Gonadotropin-Releasing Hormone | |
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| Clinical Male Gonadal Disorders | |
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| Klinefelter's Syndrome (XXY Seminiferous Tubule Dysgenesis) | |
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| Bilateral Anorchia (Vanishing Testes Syndrome) | |
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| Leydig Cell Aplasia | |
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| Cryptorchidism | |
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| Noonan's Syndrome (Male Turner's Syndrome) | |
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| Myotonic Dystrophy | |
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| Adult Seminiferous Tubule Failure | |
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| Adult Leydig Cell Failure (Andropause) | |
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| Male Infertility | |
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| Erectile Dysfunction (Impotence) | |
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| Gynecomastia | |
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| Testicular Tumors | |
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| Female Reproductive Endocrinology & Infertility | |
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| Embryology & Anatomy | |
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| Ovarian Steroidogenesis | |
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| Physiology of Folliculogenesis & the Menstrual Cycle | |
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| Menstrual Disturbances | |
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| Amenorrhea | |
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| Hypothalamic Amenorrhea | |
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| Pituitary Amenorrhea | |
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| Ovarian Amenorrhea | |
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| Anovulation | |
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| Obesity | |
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| Outflow Tract Disorders | |
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| Menopause | |
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| Oocyte Depletion | |
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| Endocrine System Changes with Aging | |
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| Menopausal Consequences | |
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| Infertility | |
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| Diagnosis of Infertility | |
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| Management of the Infertile Couple | |
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| Contraception | |
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| Oral Contraceptives | |
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| Contraception: Long-Acting Contraceptives | |
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| Emergency Contraception | |
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| Disorders of Sexual Determination & Differentiation | |
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| Normal Sex Differentiation | |
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| Testicular & Ovarian Differentiation | |
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| Psychosexual Differentiation | |
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| Atypical Sex Differentiation | |
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| Klinefelter's Syndrome and Its Variants: Seminiferous Tubule Dysgenesis | |
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| Syndrome of Gonadal Dysgenesis: Turner's Syndrome & Its Variants | |
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| Individuals with Both Ovarian and Testicular Tissue (True Hermaphroditism) | |
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| Female Pseudohermaphroditism | |
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| P450 Aromatase Deficiency | |
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| Maternal Androgens & Progestogens | |
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| Male Pseudohermaphroditism | |
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| Unclassified Forms of Abnormal Sexual Development in Males | |
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| Unclassified Forms of Abnormal Sexual Development in Females | |
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| Management of Patients with Intersex Problems | |
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| Puberty | |
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| Physiology of Puberty | |
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| Delayed Puberty or Absent Puberty (Sexual Infantilism) | |
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| Precocious Puberty (Sexual Precocity) | |
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| The Endocrinology of Pregnancy | |
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| Conception & Implantation | |
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| Fetal-Placental-Decidual Unit | |
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| Polypeptide Hormones | |
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| Steroid Hormones | |
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| Maternal Adaptation to Pregnancy | |
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| Fetal Endocrinology | |
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| Endocrine Control of Parturition | |
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| Endocrinology of the Puerperium | |
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| Endocrine Disorders & Pregnancy Pituitary Disorders | |
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| Pregnancy & Breast Cancer | |
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| Hypertensive Disorders of Pregnancy | |
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| Hyperthyroidism in Pregnancy | |
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| Hypothyroidism in Pregnancy | |
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| Pancreatic Hormones & Diabetes Mellitus | |
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| The Endocrine Pancreas | |
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| Anatomy & Histology | |
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| Hormones of the Endocrine Pancreas | |
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| Diabetes Mellitus | |
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| Classification | |
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| Diabetes Mellitus | |
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| Diabetes | |
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| Other Specific Types of Diabetes | |
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| Clinical Features of Diabetes Mellitus | |
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| Diabetes | |
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| Diabetes | |
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| Urinalysis | |
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| Blood Glucose Testing | |
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| Serum Ketone Determinations | |
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| Glycated Hemoglobin Assays | |
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| Lipoproteins in Diabetes | |
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| Oral Glucose Tolerance Test | |
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| Insulin Levels | |
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| Intravenous Glucose Tolerance Test | |
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| Diet | |
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| Agents for the Treatment of Hyperglycemia | |
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| Insulin | |
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| Steps in the Management of the Diabetic Patient | |
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| Hypoglycemia | |
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| Coma | |
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| Specific Chronic Complications of Diabetes Mellitus | |
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| Diabetic Patients Regulated by Diet Alone | |
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| Diabetic Patients Taking Oral Hypoglycemic Agents | |
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| Diabetic Patients Taking Insulin | |
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| Hypoglycemic Disorders | |
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| Pathophysiology of the Counterregulatory Response to Neuroglycopenia | |
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| Classification of Hypoglycemic Disorders | |
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| Clinical Presentation of Hypoglycemia | |
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| Specific Hypoglycemic Disorders | |
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| Symptomatic Fasting Hypoglycemia with Hyperinsulinism | |
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| Symptomatic Fasting Hypoglycemia without Hyperinsulinism | |
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| Nonfasting Hypoglycemia (Reactive Hypoglycemia) | |
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| Congenital Hyperinsulinism | |
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| Disorders of Lipoprotein Metabolism | |
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| Atherosclerosis | |
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| Overview of Lipid Transport | |
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| Differentiation of Disorders of Lipoprotein Metabolism | |
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| Clinical Descriptions of Primary & Secondary Disorders of Lipoprotein Metabolism | |
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| Primary Hypertriglyceridemia | |
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| Secondary Hypertriglyceridemia | |
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| Familial Hypercholesterolemia | |
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| Familial Combined Hyperlipidemia | |
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| Lp(a) Hyperlipoproteinemia | |
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| Familial Ligand-Defective Apo B | |
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| Cholesterol 7-[alpha]-Hydroxylase Deficiency | |
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| Hypothyroidism | |
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| Nephrosis | |
| |
| |
| Immunoglobulin Disorders | |
| |
| |
| Anorexia Nervosa | |
| |
| |
| Cholestasis | |
| |
| |
| Primary Hypolipidemia Due to Deficiency of High-Density Lipoproteins | |
| |
| |
| Primary Hypolipidemia Due to Deficiency of Apo B-Containing Lipoproteins | |
| |
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| The Lipodystrophies | |
| |
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| Rare Disorders | |
| |
| |
| Treatment of Hyperlipidemia | |
| |
| |
| Bile Acid Sequestrants | |
| |
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| Niacin (Nicotinic Acid) | |
| |
| |
| Fibric Acid Derivatives | |
| |
| |
| HMG-CoA Reductase Inhibitors | |
| |
| |
| Cholesterol Absorption Inhibitors | |
| |
| |
| Combined Drug Therapy | |
| |
| |
| Obesity & Overweight | |
| |
| |
| Clarification of Uncertainties Regarding the Pathogenesis of Obesity | |
| |
| |
| Survey of Treatment Approaches & Their Efficacy | |
| |
| |
| Diet & Exercise | |
| |
| |
| Exercise | |
| |
| |
| Surgical Treatment of Obesity | |
| |
| |
| Pharmacologic Therapies | |
| |
| |
| Other Conditions Affected by Treatment of Obesity or Overweight | |
| |
| |
| Type 2 Diabetes Mellitus | |
| |
| |
| Hyperlipidemia | |
| |
| |
| Polycystic Ovarian Syndrome | |
| |
| |
| Hypertension | |
| |
| |
| Gallstones | |
| |
| |
| Sleep Apnea | |
| |
| |
| Osteoarthritis & Other Weight-Sensitive States | |
| |
| |
| A Systematic Approach to the Treatment of Obesity | |
| |
| |
| Humoral Manifestations of Malignancy | |
| |
| |
| Ectopic Hormone & Receptor Syndromes | |
| |
| |
| Hypercalcemia of Malignancy | |
| |
| |
| Ectopic Cushing's Syndrome | |
| |
| |
| Syndrome of Inappropriate Anridiuretic Hormone Secretion | |
| |
| |
| Non-Islet Cell Tumors & Hypoglycemia | |
| |
| |
| Other Hormones Secreted by Tumors | |
| |
| |
| Oncogenic Osteomalacia | |
| |
| |
| Gut Hormones | |
| |
| |
| Multiple Endocrine Neoplasia | |
| |
| |
| Multiple Endocrine Neoplasia Type 1 (Men 1) | |
| |
| |
| Multiple Endocrine Neoplasia Type 2 (Men 2) | |
| |
| |
| Other Disorders Characterized by Multiple Endocrine Organ Involvement | |
| |
| |
| Geriatric Endocrinology | |
| |
| |
| Thyroid Function & Disease | |
| |
| |
| Disorders of the Thyroid Gland | |
| |
| |
| Carbohydrate Intolerance & Diabetes Mellitus | |
| |
| |
| Aging & the Physiology of Carbohydrate Intolerance | |
| |
| |
| Diabetes Mellitus | |
| |
| |
| Nonketotic Hyperosmolar Coma | |
| |
| |
| Osteoporosis & Calcium Homeostasis | |
| |
| |
| Osteoporosis | |
| |
| |
| Hyperparathyroidism | |
| |
| |
| Changes in Water Balance | |
| |
| |
| Hypernatremia | |
| |
| |
| Hyponatremia | |
| |
| |
| Hyporeninemic Hypoaldosteronism | |
| |
| |
| Glucocorticoids & Stress | |
| |
| |
| Disorders of the Hypothalamic-Pituitary-Adrenal Axis | |
| |
| |
| Changes in Reproductive Function in Men | |
| |
| |
| Benign Prostatic Hyperplasia | |
| |
| |
| Endocrine Emergencies | |
| |
| |
| Myxedema Coma | |
| |
| |
| Thyroid Storm | |
| |
| |
| Thyrotoxic Periodic Paralysis | |
| |
| |
| Amiodarone-Induced Thyrotoxicosis | |
| |
| |
| Acute Adrenal Insufficiency | |
| |
| |
| Pituitary Apoplexy | |
| |
| |
| Diabetic Ketoacidosis | |
| |
| |
| Nonketotic Hyperosmolar Coma | |
| |
| |
| Hypercalcemic Crisis | |
| |
| |
| Acute Hypocalcemia | |
| |
| |
| Hyponatremia | |
| |
| |
| Diabetes Insipidus | |
| |
| |
| AIDS Endocrinopathies | |
| |
| |
| Thyroid Disorders | |
| |
| |
| Adrenal Disorders | |
| |
| |
| Bone & Mineral Disorders | |
| |
| |
| Gonadal Disorders | |
| |
| |
| Pituitary Disorders | |
| |
| |
| Lipid Disorders | |
| |
| |
| Conclusion | |
| |
| |
| Endocrine Surgery | |
| |
| |
| The Thyroid Gland | |
| |
| |
| Embryology & Anatomy | |
| |
| |
| Developmental Thyroid Abnormalities | |
| |
| |
| Hyperthyroidism | |
| |
| |
| Thyroiditis | |
| |
| |
| Goiter (Nontoxic) | |
| |
| |
| Thyroid Nodules | |
| |
| |
| Thyroid Cancer | |
| |
| |
| Conduct of Thyroidectomy | |
| |
| |
| The Parathyroid Gland | |
| |
| |
| Embryology & Anatomy | |
| |
| |
| Primary Hyperparathyroidism (PHPT) | |
| |
| |
| Persistent & Recurrent Primary Hyperparathyroidism | |
| |
| |
| Secondary Hyperparathyroidism | |
| |
| |
| Special Consideration: Familial Hyperparathyroidism | |
| |
| |
| Complications of Parathyroid Surgery | |
| |
| |
| The Adrenal (Suprarenal) Gland | |
| |
| |
| Embryology & Anatomy | |
| |
| |
| Primary Hyperaldosteronism | |
| |
| |
| Hypercortisolism | |
| |
| |
| Adrenal Cortical Carcinoma | |
| |
| |
| Sex Steroid Excess | |
| |
| |
| Pheochromocytoma | |
| |
| |
| Adrenal Incidentaloma | |
| |
| |
| Technique of Adrenalectomy | |
| |
| |
| The Endocrine Pancreas | |
| |
| |
| Embryology & Anatomy | |
| |
| |
| Insulinoma | |
| |
| |
| Gastrinoma (Zollinger-Ellison Syndrome) | |
| |
| |
| VIPoma (Verner-Morrison) Syndrome | |
| |
| |
| Glucagonoma | |
| |
| |
| Somatostatinoma | |
| |
| |
| Nonfunctioning Pancreatic Tumors | |
| |
| |
| Normal Hormone Reference Ranges | |
| |
| |
| Index | |