| Authors | p. xii |
| Preface | p. xvi |
| Introduction to Endocrinology | p. 1 |
| The Endocrine System | p. 2 |
| Hormones: Endocrine, Paracrine, & Autocrine Actions | p. 3 |
| Chemical Composition of Hormones | p. 3 |
| Relationships between Hormones & Other Signaling Molecules | p. 4 |
| Neurotransmitters & Hormones | p. 4 |
| Vitamins & Hormones | p. 5 |
| Oncogenes & Hormones | p. 5 |
| The Immune System & Hormones | p. 5 |
| Eicosanoids: Prostaglandins & Related Compounds | p. 6 |
| Mechanisms of Hormone Action | p. 6 |
| Hormone Receptors | p. 6 |
| Hormone Effects on Receptor Activity | p. 8 |
| Classes of Hormone Action | p. 8 |
| Classification of Hormone Action by Receptor Type | p. 8 |
| Classification of Hormone Action by Ligand Type | p. 9 |
| Mechanisms of Ligand Action | p. 10 |
| Regulation of Hormone Responsiveness | p. 11 |
| Hormone Responses Can Be Self-Limiting | p. 11 |
| Different Signals Influence Hormone Responsiveness | p. 11 |
| Modulation of Hormone Levels | p. 12 |
| Hormone Synthesis | p. 12 |
| Regulation of Hormone Production | p. 12 |
| Hormone Transport in the Circulation | p. 13 |
| Transport of Hormones across the Membrane | p. 14 |
| Metabolism & Elimination of Hormones | p. 14 |
| Recombinant DNA, Genomics, Proteomics, & Endocrinology | p. 15 |
| Sequencing of the Human Genome | p. 16 |
| Genomics & Patterns of Transcription | p. 16 |
| Proteomics | p. 16 |
| Molecular Basis of Genetic Endocrine Disease | p. 17 |
| Evolution of the Endocrine System | p. 17 |
| The Origins of Regulatory Chemicals & the Metabolic Code | p. 18 |
| Evolution of Hormones & Receptors | p. 18 |
| Evolution of Multiple Hormone Response Systems | p. 19 |
| Evolution of Endocrine Glands | p. 19 |
| Integrative Networks | p. 19 |
| Endocrine & Nervous System Relationships: Neuroendocrinology | p. 19 |
| Hypothalamic-Pituitary Relationships | p. 20 |
| Endocrine Organs & Hormone Production | p. 21 |
| Actions of Hormones | p. 21 |
| Hormone Release | p. 21 |
| Fetal Development | p. 21 |
| Cell Growth & Cancer | p. 21 |
| Hormonal Effects on Intermediary Metabolism | p. 22 |
| Hormonal Effects on Mineral & Water Metabolism | p. 22 |
| Hormonal Effects on Cardiovascular & Renal Function | p. 22 |
| Hormonal Effects on Skeletal Function | p. 23 |
| Hormonal Effects on Reproductive Function | p. 23 |
| Hormonal Effects on the Immune System | p. 23 |
| Hormonal Effects on the Central Nervous System | p. 23 |
| Selective Modulation | p. 24 |
| Disorders of the Endocrine System | p. 24 |
| Endocrine Hypofunction | p. 25 |
| Endocrine Hyperfunction | p. 25 |
| Defects in Sensitivity to Hormones | p. 26 |
| Syndromes of Hormone Excess Due to Administration of Exogenous Hormone | p. 27 |
| Nonendocrine Problems Associated with Endocrine Disease | p. 28 |
| Approach to the Patient with Endocrine Disease | p. 28 |
| Evidence-Based Endocrinology | p. 28 |
| History & Physical Examination | p. 29 |
| Laboratory Studies | p. 29 |
| Screening for Endocrine Diseases | p. 33 |
| Clinical Interpretation of Laboratory Tests | p. 34 |
| Treatment of Endocrine Diseases | p. 34 |
| Uses of Hormones & Selective Modulators in Therapy of Nonendocrine Disease | p. 35 |
| Hormone Synthesis & Release | p. 38 |
| Compartmentation of Eukaryotic Cells in Relation to Hormone Synthesis & Release | p. 38 |
| Overview of Hormone Biosynthesis | p. 39 |
| Membrane Vesicle-Mediated Hormone Export | p. 40 |
| Hormone Export Not Mediated by Membrane Vesicles | p. 51 |
| Metabolism, Transport, Elimination, & Regulation of Hormones | p. 56 |
| Mechanisms of Hormone Action | p. 61 |
| Receptors | p. 62 |
| Neurotransmitter & Peptide Hormone Receptors | p. 63 |
| G Protein-Coupled Receptors | p. 64 |
| G Protein Transducers | p. 65 |
| G Protein Disorders | p. 66 |
| Effectors | p. 67 |
| G Protein-Coupled Receptors & Human Disease | p. 68 |
| Growth Factor Receptors | p. 70 |
| Cytokine Receptors | p. 73 |
| Guanylyl Cyclase-Linked Receptors | p. 73 |
| Nuclear Action of Peptide Hormones | p. 74 |
| Nuclear Receptors | p. 75 |
| Steroid Receptor Family | p. 76 |
| Thyroid Receptor Family | p. 77 |
| Nongenomic Effects of the Steroid Hormones | p. 82 |
| Steroid & Thyroid Hormone Receptor Resistance Syndromes | p. 83 |
| Endocrine Autoimmunity | p. 85 |
| Basic Immune Components & Mechanisms | p. 86 |
| Immune Recognition & Response | p. 87 |
| Tolerance | p. 90 |
| Autoimmunity Is Multifactorial | p. 95 |
| Genetic Factors in Autoimmunity | p. 95 |
| Environmental Factors in Autoimmunity | p. 96 |
| Single Gland Autoimmune Syndromes | p. 96 |
| Autoimmune Aspects of Thyroid Disease | p. 97 |
| Autoimmune Aspects of Type 1 Diabetes | p. 98 |
| Autoimmune Aspects of Other Endocrinopathies | p. 100 |
| Autoimmune Polyglandular Syndromes | p. 103 |
| Autoimmune Polyglandular Syndrome I (APS-I) | p. 103 |
| Autoimmune Polyglandular Syndrome II (APS-II) | p. 103 |
| Management of Autoimmune Polyglandular Syndromes | p. 104 |
| Hypothalamus & Pituitary Gland | p. 106 |
| Hypothalamic Hormones | p. 111 |
| Anterior Pituitary Hormones | p. 119 |
| ACTH & Related Peptides | p. 119 |
| Growth Hormone | p. 120 |
| Prolactin | p. 125 |
| Thyrotropin | p. 126 |
| Gonadotropins: Luteinizing Hormone, Follicle-Stimulating Hormone | p. 128 |
| Endocrinologic Evaluation of the Hypothalamic-Pituitary Axis | p. 129 |
| Evaluation of ACTH | p. 129 |
| Evaluation of Growth Hormone | p. 131 |
| Evaluation of Prolactin | p. 132 |
| Evaluation of TSH | p. 132 |
| Evaluation of LH & FSH | p. 132 |
| Problems in Evaluation of the Hypothalamic-Pituitary Axis | p. 133 |
| Effects of Pharmacologic Agents on Hypothalamic-Pituitary Function | p. 133 |
| Endocrine Tests of Hypothalamic-Pituitary Function | p. 133 |
| Neuroradiologic Evaluation | p. 136 |
| Pituitary & Hypothalamic Disorders | p. 136 |
| Empty Sella Syndrome | p. 138 |
| Hypothalamic Dysfunction | p. 139 |
| Hypopituitarism | p. 140 |
| Pituitary Adenomas | p. 147 |
| Posterior Pituitary | p. 163 |
| Antidiuretic Hormone (ADH; Vasopressin) | p. 163 |
| Oxytocin | p. 164 |
| Control of Water Balance | p. 164 |
| Diabetes Insipidus | p. 167 |
| Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH) | p. 170 |
| Growth | p. 176 |
| Normal Growth | p. 176 |
| Intrauterine Growth | p. 176 |
| The Placenta | p. 177 |
| Classic Hormones of Growth & Fetal Growth | p. 177 |
| Growth Factors & Oncogenes in Fetal Growth | p. 177 |
| Insulin-Like Growth Factors, Receptors, & Binding Proteins | p. 177 |
| Insulin | p. 178 |
| Epidermal Growth Factor | p. 178 |
| Fetal Origins of Adult Disease | p. 179 |
| Postnatal Growth | p. 179 |
| Measurement of Growth | p. 187 |
| Skeletal (Bone) Age | p. 191 |
| Disorders of Growth | p. 194 |
| Short Stature Due to Nonendocrine Causes | p. 194 |
| Short Stature Due to Endocrine Disorders | p. 198 |
| The Diagnosis of Short Stature | p. 210 |
| Tall Stature Due to Nonendocrine Causes | p. 211 |
| Beckwith-Wiedemann Syndrome | p. 212 |
| Tall Stature Due to Endocrine Disorders | p. 212 |
| The Thyroid Gland | p. 215 |
| Anatomy & Histology | p. 216 |
| Physiology | p. 216 |
| Structure of Thyroid Hormones | p. 216 |
| Iodine Metabolism | p. 216 |
| Thyroid Hormone Synthesis & Secretion | p. 219 |
| Abnormalities in Thyroid Hormone Synthesis & Release | p. 224 |
| Thyroid Hormone Transport | p. 225 |
| Metabolism of Thyroid Hormones | p. 227 |
| Control of Thyroid Function | p. 232 |
| The Action of Thyroid Hormones | p. 238 |
| Physiologic Changes in Thyroid Function | p. 241 |
| Thyroid Autoimmunity | p. 243 |
| Tests of Thyroid Function | p. 244 |
| Tests of Thyroid Hormones in Blood | p. 244 |
| Evaluation of the Hypothalamic-Pituitary-Thyroid Axis | p. 245 |
| Iodine Metabolism & Biosynthetic Activity | p. 245 |
| Thyroid Imaging | p. 247 |
| Thyroid Ultrasonography or Magnetic Resonance Imaging | p. 248 |
| Thyroid Biopsy | p. 249 |
| Effects of Thyroid Hormones on Peripheral Tissues | p. 249 |
| Measurement of Thyroid Autoantibodies | p. 250 |
| Summary: Clinical Use of Thyroid Function Tests | p. 250 |
| Disorders of the Thyroid | p. 251 |
| Hypothyroidism | p. 251 |
| Hyperthyroidism & Thyrotoxicosis | p. 260 |
| Thyroid Hormone Resistance Syndromes | p. 272 |
| Nontoxic Goiter | p. 273 |
| Thyroiditis | p. 275 |
| Effects of Ionizing Radiation on the Thyroid Gland | p. 278 |
| Thyroid Nodules & Thyroid Cancer | p. 279 |
| Metabolic Bone Disease | p. 295 |
| Cellular & Extracellular Calcium Metabolism | p. 295 |
| Parathyroid Hormone | p. 296 |
| Calcitonin | p. 302 |
| Vitamin D | p. 304 |
| Integrated Control of Mineral Homeostasis | p. 311 |
| Medullary Thyroid Carcinoma | p. 311 |
| Hypercalcemia | p. 313 |
| Disorders Causing Hypercalcemia | p. 314 |
| Treatment of Hypercalcemia | p. 323 |
| Hypocalcemia | p. 324 |
| Causes of Hypocalcemia | p. 325 |
| Treatment of Hypocalcemia | p. 329 |
| Bone Anatomy & Remodeling | p. 330 |
| Functions of Bone | p. 330 |
| Structure of Bone | p. 330 |
| Bone Remodeling | p. 332 |
| Osteoporosis | p. 335 |
| Treatment of Osteoporosis | p. 338 |
| Nonpharmacologic Aspects of Osteoporosis Management | p. 343 |
| Glucocorticoid-Induced Osteoporosis | p. 343 |
| Osteomalacia & Rickets | p. 345 |
| Nephrotic Syndrome | p. 348 |
| Hepatic Osteodystrophy | p. 349 |
| Drug-Induced Osteomalacia | p. 349 |
| Hypophosphatemic Disorders | p. 349 |
| Calcium Deficiency | p. 351 |
| Primary Disorders of the Bone Matrix | p. 351 |
| Inhibitors of Mineralization | p. 352 |
| Paget's Disease of Bone (Osteitis Deformans) | p. 352 |
| Renal Osteodystrophy | p. 357 |
| Glucocorticoids & Adrenal Androgens | p. 362 |
| Embryology & Anatomy | p. 363 |
| Biosynthesis of Cortisol & Adrenal Androgens | p. 364 |
| Circulation of Cortisol & Adrenal Androgens | p. 371 |
| Metabolism of Cortisol & Adrenal Androgens | p. 371 |
| Biologic Effects of Adrenal Steroids | p. 372 |
| Glucocorticoids | p. 372 |
| Adrenal Androgens | p. 380 |
| Laboratory Evaluation | p. 380 |
| Disorders of Adrenocortical Insufficiency | p. 384 |
| Primary Adrenocortical Insufficiency (Addison's Disease) | p. 384 |
| Secondary Adrenocortical Insufficiency | p. 389 |
| Diagnosis of Adrenocortical Insufficiency | p. 390 |
| Treatment of Adrenocortical Insufficiency | p. 393 |
| Prognosis of Adrenocortical Insufficiency | p. 395 |
| Cushing's Syndrome | p. 395 |
| Hirsutism & Virilism | p. 408 |
| Incidental Adrenal Mass | p. 408 |
| Glucocorticoid Therapy for Nonendocrine Disorders | p. 410 |
| Endocrine Hypertension | p. 414 |
| Hypertension of Adrenal Origin | p. 414 |
| Synthesis, Metabolism, & Action of Mineralocorticoid Hormones | p. 414 |
| Pathogenesis of Mineralocorticoid Hypertension | p. 416 |
| Aldosterone & the Heart | p. 417 |
| Primary Aldosteronism | p. 417 |
| Syndromes Due to Excess Deoxycorticosterone Production | p. 422 |
| Cushing's Syndrome | p. 424 |
| Pseudohyperaldosteronism | p. 425 |
| Type II Pseudohypoaldosteronism (Arnold-Healy-Gordon Syndrome) | p. 427 |
| Hypertension of Renal Origin | p. 428 |
| The Renin-Angiotensin System | p. 428 |
| The Renin-Angiotensin System & Hypertension | p. 431 |
| Other Hormone Systems & Hypertension | p. 435 |
| Insulin | p. 435 |
| Natriuretic Peptides | p. 436 |
| Endothelium-Derived Relaxing Factor | p. 436 |
| Endothelin | p. 436 |
| Kallikrein-Kinin System | p. 437 |
| Other Hormones & Autacoids | p. 437 |
| Sympathetic Nervous System | p. 437 |
| Adrenal Medulla | p. 439 |
| History | p. 439 |
| Anatomy | p. 440 |
| Hormones of the Adrenal Medulla | p. 441 |
| Catecholamines | p. 441 |
| Other Hormones | p. 451 |
| Disorders of Adrenal Medullary Function | p. 451 |
| Adrenal Medullary Hypofunction | p. 451 |
| Adrenal Medullary Hyperfunction | p. 453 |
| Pheochromocytoma | p. 453 |
| Testes | p. 478 |
| Anatomy & Structure-Function Relationships | p. 478 |
| Testes | p. 478 |
| Accessory Structures | p. 480 |
| Physiology of the Male Reproductive System | p. 480 |
| Gonadal Steroids | p. 480 |
| Control of Testicular Function | p. 483 |
| Evaluation of Male Gonadal Function | p. 484 |
| Clinical Evaluation | p. 484 |
| Laboratory Tests of Testicular Function | p. 486 |
| Pharmacology of Drugs Used to Treat Male Gonadal Disorders | p. 488 |
| Androgens | p. 489 |
| Gonadotropins | p. 490 |
| Gonadotropin-Releasing Hormone | p. 490 |
| Clinical Male Gonadal Disorders | p. 490 |
| Klinefelter's Syndrome (XXY Seminiferous Tubule Dysgenesis) | p. 491 |
| Bilateral Anorchia (Vanishing Testes Syndrome) | p. 493 |
| Cryptorchidism | p. 494 |
| Noonan's Syndrome (Male Turner's Syndrome) | p. 496 |
| Myotonic Dystrophy | p. 497 |
| Adult Leydig Cell Failure (Andropause) | p. 499 |
| Male Infertility | p. 500 |
| Erectile Dysfunction (Impotence) | p. 502 |
| Gynecomastia | p. 505 |
| Testicular Tumors | p. 508 |
| Female Reproductive Endocrinology & Infertility | p. 511 |
| Embryology & Anatomy | p. 511 |
| Ovarian Steroidogenesis | p. 514 |
| Physiology of the Menstrual Cycle | p. 514 |
| Menstrual Disturbances | p. 522 |
| Hypothalamic Amenorrhea | p. 522 |
| Pituitary Amenorrhea | p. 525 |
| Ovarian Amenorrhea | p. 528 |
| Adrenal Causes of Amenorrhea | p. 535 |
| Outflow Tract Disorders | p. 538 |
| Menopause | p. 539 |
| Oocyte Depletion | p. 540 |
| Endocrine System Changes with Aging | p. 541 |
| Menopausal Consequences | p. 542 |
| Infertility | p. 544 |
| Diagnosis of Infertility | p. 545 |
| Management of the Infertile Couple | p. 546 |
| Contraception | p. 547 |
| Oral Contraceptives | p. 548 |
| Contraception: Long-Acting Contraceptives | p. 555 |
| Emergency Contraception | p. 561 |
| Abnormalities of Sexual Determination & Differentiation | p. 564 |
| Normal Sex Differentiation | p. 564 |
| Testicular & Ovarian Differentiation | p. 569 |
| Psychosexual Differentiation | p. 576 |
| Abnormal Sex Differentiation | p. 576 |
| Seminiferous Tubule Dysgenesis: Chromatin-Positive Klinefelter's Syndrome & Its Variants | p. 576 |
| Syndrome of Gonadal Dysgenesis: Turner's Syndrome & Its Variants | p. 579 |
| True Hermaphroditism | p. 583 |
| Female Pseudohermaphroditism | p. 584 |
| P450 Aromatase Deficiency | p. 589 |
| Maternal Androgens & Progestogens | p. 589 |
| Male Pseudohermaphroditism | p. 589 |
| Unclassified Forms of Abnormal Sexual Development in Males | p. 599 |
| Unclassified Forms of Abnormal Sexual Development in Females | p. 601 |
| Management of Patients with Intersex Problems | p. 601 |
| Puberty | p. 608 |
| Physiology of Puberty | p. 608 |
| Delayed Puberty or Absent Puberty (Sexual Infantilism) | p. 617 |
| Precocious Puberty (Sexual Precocity) | p. 628 |
| The Endocrinology of Pregnancy | p. 637 |
| Conception & Implantation | p. 637 |
| Fetal-Placental-Decidual Unit | p. 638 |
| Polypeptide Hormones | p. 641 |
| Steroid Hormones | p. 642 |
| Maternal Adaptation to Pregnancy | p. 643 |
| Fetal Endocrinology | p. 647 |
| Endocrine Control of Parturition | p. 649 |
| Endocrinology of the Puerperium | p. 650 |
| Endocrine Disorders & Pregnancy | p. 652 |
| Pituitary Disorders | p. 652 |
| Pregnancy & Breast Cancer | p. 653 |
| Hypertensive Disorders of Pregnancy | p. 654 |
| Hyperthyroidism in Pregnancy | p. 655 |
| Hypothyroidism in Pregnancy | p. 656 |
| Pancreatic Hormones & Diabetes Mellitus | p. 658 |
| The Endocrine Pancreas | p. 658 |
| Anatomy & Histology | p. 658 |
| Hormones of the Endocrine Pancreas | p. 660 |
| Diabetes Mellitus | p. 669 |
| Classification | p. 669 |
| Type 1 Diabetes Mellitus | p. 669 |
| Type 2 Diabetes | p. 672 |
| Other Specific Types of Diabetes | p. 675 |
| Clinical Features of Diabetes Mellitus | p. 678 |
| Type 1 Diabetes | p. 678 |
| Type 2 Diabetes | p. 679 |
| Urinalysis | p. 679 |
| Blood Glucose Testing | p. 681 |
| Serum Ketone Determinations | p. 682 |
| Glycated Hemoglobin Assays | p. 682 |
| Lipoproteins in Diabetes | p. 683 |
| Diagnosis of Diabetes Mellitus | p. 683 |
| Oral Glucose Tolerance Test | p. 684 |
| Insulin Levels | p. 684 |
| Intravenous Glucose Tolerance Test | p. 685 |
| Treatment of Diabetes Mellitus | p. 689 |
| Diet | p. 689 |
| Oral Agents for the Treatment of Hyperglycemia | p. 690 |
| Insulin | p. 698 |
| Steps in the Management of the Diabetic Patient | p. 704 |
| Acute Complications of Diabetes Mellitus | p. 711 |
| Hypoglycemia | p. 711 |
| Coma | p. 714 |
| Chronic Complications of Diabetes Mellitus | p. 723 |
| Specific Chronic Complications of Diabetes Mellitus | p. 725 |
| Surgery in the Diabetic Patient | p. 732 |
| Diabetics Regulated by Diet Alone | p. 732 |
| Diabetics Taking Oral Hypoglycemic Agents | p. 732 |
| Diabetics Taking Insulin | p. 732 |
| Diabetes Mellitus & Pregnancy (by John L. Kitzmiller, MD) | p. 733 |
| Prognosis for Patients with Diabetes Mellitus | p. 741 |
| Hypoglycemic Disorders | p. 747 |
| Pathophysiology of the Counterregulatory Response to Neuroglycopenia | p. 747 |
| Classification of Hypoglycemic Disorders | p. 752 |
| Clinical Presentation of Hypoglycemia | p. 753 |
| Specific Hypoglycemic Disorders | p. 754 |
| Symptomatic Fasting Hypoglycemia with Hyperinsulinism | p. 754 |
| Symptomatic Fasting Hypoglycemia without Hyperinsulinism | p. 762 |
| Nonfasting Hypoglycemia (Reactive Hypoglycemia) | p. 763 |
| Disorders of Lipoprotein Metabolism | p. 766 |
| Atherosclerosis | p. 766 |
| Overview of Lipid Transport | p. 767 |
| Differentiation of Disorders of Lipoprotein Metabolism | p. 771 |
| Clinical Descriptions of Primary & Secondary Disorders of Lipoprotein Metabolism | p. 774 |
| The Hypertriglyceridemias | p. 774 |
| Primary Hypertriglyceridemia | p. 774 |
| Secondary Hypertriglyceridemia | p. 778 |
| The Primary Hypercholesterolemias | p. 780 |
| Familial Hypercholesterolemia | p. 780 |
| Familial Combined Hyperlipidemia | p. 781 |
| LP(a) Hyperlipoproteinemia | p. 781 |
| Familial Ligand-Defective APO B | p. 781 |
| Cholesterol 7-[alpha]-Hydroxylase Deficiency | p. 781 |
| Secondary Hypercholesterolemia | p. 782 |
| Hypothyroidism | p. 782 |
| Nephrosis | p. 782 |
| Immunoglobulin Disorders | p. 782 |
| Anorexia Nervosa | p. 782 |
| Cholestasis | p. 782 |
| The Primary Hypolipidemias | p. 783 |
| Primary Hypolipidemia Due to Deficiency of High-Density Lipoproteins | p. 783 |
| Primary Hypolipidemia Due to Deficiency of APO B-Containing Lipoproteins | p. 784 |
| Secondary Hypolipidemia | p. 785 |
| Other Disorders of Lipoprotein Metabolism | p. 785 |
| The Lipodystrophies | p. 785 |
| Rare Disorders | p. 786 |
| Treatment of Hyperlipidemia | p. 787 |
| Dietary Factors in the Management of Lipoprotein Disorders | p. 787 |
| Drugs Used in Treatment of Hyperlipoproteinemia | p. 789 |
| Bile Acid Sequestrants | p. 789 |
| Niacin (Nicotinic Acid) | p. 789 |
| Fibric Acid Derivatives | p. 790 |
| HMG-CoA Reductase Inhibitors | p. 790 |
| Combined Drug Therapy | p. 791 |
| Possible Untoward Consequences of Lipid-Lowering Therapy | p. 792 |
| Obesity & Overweight | p. 794 |
| Controversies & Uncertainties Regarding the Pathogenesis of Obesity | p. 804 |
| Survey of Treatment Approaches & Their Efficacy | p. 806 |
| Dietary Therapies | p. 806 |
| Surgical Treatment of Obesity | p. 807 |
| Pharmacologic Therapies | p. 807 |
| Other Conditions Affected by Treatment of Obesity or Overweight | p. 810 |
| Type 2 Diabetes Mellitus | p. 810 |
| Hyperlipidemia | p. 812 |
| Polycystic Ovarian Syndrome | p. 812 |
| Hypertension | p. 812 |
| Gallstones | p. 812 |
| Osteoarthritis & Other Weight-Sensitive States | p. 812 |
| A Systematic Approach to the Treatment of Obesity | p. 813 |
| Humoral Manifestations of Malignancy | p. 814 |
| Ectopic Hormone & Receptor Syndromes | p. 814 |
| Hypercalcemia of Malignancy | p. 815 |
| Ectopic Cushing's Syndrome | p. 819 |
| Syndrome of Inappropriate ADH (SIADH) Secretion | p. 822 |
| Non-Islet Cell Tumors & Hypoglycemia | p. 823 |
| Other Hormones Secreted by Tumors | p. 824 |
| Oncogenic Osteomalacia | p. 825 |
| Gut Hormones | p. 826 |
| Multiple Endocrine Neoplasia | p. 829 |
| Multiple Endocrine Neoplasia Type 1 (MEN 1) | p. 829 |
| Multiple Endocrine Neoplasia Type 2 (MEN 2) | p. 834 |
| Other Disorders Characterized by Multiple Endocrine Organ Involvement | p. 840 |
| Geriatric Endocrinology | p. 842 |
| Thyroid Function & Disease | p. 842 |
| Disorders of the Thyroid Gland | p. 843 |
| Carbohydrate Intolerance & Diabetes Mellitus | p. 847 |
| Aging & the Physiology of Carbohydrate Intolerance | p. 847 |
| Diabetes Mellitus | p. 847 |
| Nonketotic Hyperosmolar Coma | p. 849 |
| Osteoporosis & Calcium Homeostasis | p. 850 |
| Osteoporosis | p. 850 |
| Hyperparathyroidism | p. 858 |
| Changes in Water Balance | p. 858 |
| Hypernatremia | p. 859 |
| Hyponatremia | p. 859 |
| Hyporeninemic Hypoaldosteronism | p. 859 |
| Glucocorticoids & Stress | p. 859 |
| Disorders of the Hypothalamic-Pituitary-Adrenal Axis | p. 860 |
| Changes in Reproductive Function in Men | p. 861 |
| Benign Prostatic Hyperplasia | p. 862 |
| Endocrine Emergencies | p. 867 |
| Myxedema Coma | p. 867 |
| Thyroid Storm | p. 869 |
| Thyrotoxic Periodic Paralysis | p. 870 |
| Amiodarone Induced Thyrotoxicosis | p. 871 |
| Acute Adrenal Insufficiency | p. 872 |
| Pituitary Apoplexy | p. 873 |
| Diabetic Ketoacidosis | p. 873 |
| Nonketotic Hyperosmolar Coma | p. 878 |
| Hypercalcemic Crisis | p. 880 |
| Acute Hypocalcemia | p. 882 |
| Hyponatremia | p. 885 |
| Diabetes Insipidus | p. 888 |
| AIDS Endocrinopathies | p. 893 |
| Thyroid Disorders | p. 893 |
| Adrenal Disorders | p. 895 |
| Bone & Mineral Disorders | p. 897 |
| Gonadal Disorders | p. 897 |
| Pituitary Disorders | p. 898 |
| Pancreatic Disorders | p. 898 |
| Lipid Disorders | p. 899 |
| Conclusion | p. 900 |
| Endocrine Surgery | p. 902 |
| Introduction | p. 902 |
| The Thyroid Gland | p. 902 |
| Developmental Thyroid Abnormalities | p. 902 |
| Hyperthyroidism | p. 903 |
| Thyroiditis | p. 904 |
| Nodular Goiter | p. 904 |
| Thyroid Nodules | p. 904 |
| Thyroid Cancer | p. 904 |
| Conduct of Thyroidectomy | p. 906 |
| The Parathyroid Gland | p. 908 |
| Primary Hyperparathyroidism | p. 908 |
| Persistent & Recurrent Primary Hyperparathyroidism | p. 910 |
| Secondary Hyperparathyroidism | p. 911 |
| Special Consideration: Familial Hyperparathyroidism | p. 911 |
| Complications of Parathyroid Surgery | p. 911 |
| The Adrenal (Suprarenal) Gland | p. 911 |
| Primary Hyperaldosteronism | p. 911 |
| Hypercortisolism | p. 912 |
| Sex Steroid Excess | p. 912 |
| Pheochromocytoma | p. 913 |
| Adrenal Cortical Carcinoma | p. 913 |
| Adrenal Incidentaloma | p. 913 |
| Technique of Adrenalectomy | p. 914 |
| The Endocrine Pancreas | p. 914 |
| Insulinoma | p. 915 |
| Gastrinoma (Zollinger-Ellison Syndrome) | p. 916 |
| Vipoma (Verner-Morrison) Syndrome | p. 917 |
| Glucagonoma | p. 917 |
| Somatostatinoma | p. 917 |
| Nonfunctioning Pancreatic Tumors | p. 917 |
| Normal Hormone Reference Ranges | p. 920 |
| Index | p. 939 |
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