Basic Concepts in Biochemistry A Student's Survival Guide

ISBN-10: 0071356576
ISBN-13: 9780071356572
Edition: 2nd 2000 (Revised)
Authors: Hiram F. Gilbert
List price: $48.00 Buy it from $3.00
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Book details

List price: $48.00
Edition: 2nd
Copyright year: 2000
Publisher: McGraw-Hill Medical Publishing Division
Publication date: 12/7/1999
Binding: Paperback
Pages: 331
Size: 5.75" wide x 8.50" long x 0.75" tall
Weight: 0.836
Language: English

Preface
Prologue
Where to Start
Instructions
What Do I Need to Know?
Instructions for Use
Studying and Exams
Trivia Sorter
Protein Structure
Amino Acid Structure
Interactions
Water
Hydrophobic Interaction
van der Waals Interactions and London Dispersion Forces
Hydrogen Bonds
Secondary Structure
Protein Stability
Favorable (Good) Interactions
Unfavorable (Bad) Interactions
Temperature-Sensitive Mutations
Ligand-Binding Specificity
Global Conclusion
Membranes and Membrane Proteins
General Membrane Function
Membrane Composition
Phospholipid Bilayer
Membrane Structure
Posttranslational Modification
Membrane Fluidity
Diffusion in Membranes
Movement of Ions and Molecules Across Membranes
Transport Across Membranes
The Nernst Equation
DNA-RNA Structure
DNA Structure
DNA Stability
RNA Secondary Structure
Expression of Genetic Information
Information Metabolism
Directions and Conventions
DNA Replication
Types of DNA Polymerase
Recombination
Regulation of Information Metabolism
Transcription
Regulation of Transcription
Translation
Use of High-Energy Phosphate Bonds During Translation
Recombinant-DNA Methodology
Restriction Analysis
Gels and Electrophoresis
Blotting
Restriction Fragment-Length Polymorphism
Cloning
Sequencing
Mutagenesis
Polymerase Chain Reaction
Enzyme Mechanism
Active Site
Transition State
Catalysis
Lock and Key
Induced Fit
Nonproductive Binding
Entropy
Strain and Distortion
Transition-State Stabilization
Transition-State Analogs
Chemical Catalysis
Enzyme Kinetics
S, P, and E (Substrate, Product, Enzyme)
Amounts and Concentrations
Active Site
Assay
Velocity
Initial Velocity
Mechanism
Little k's
Michaelis-Menten Equation
V[subscript max]
K[subscript cat]
K[subscript m]
Special Points
k[subscript cat]/K[subscript m]
Rate Accelerations
Steady-State Approximation
Transformations and Graphs
Inhibition
Allosterism and Cooperativity
The Monod-Wyman-Changeaux Model
Signal Transduction Pathways
Signal Transduction Pathways
Organization
Signals
Receptors
Soluble Receptors
Transmembrane Receptors
Enzyme Coupled Receptors
G-Protein Coupled Receptors
Ion-Channel Coupled Receptors
Second Messengers
Amplifiers
Integrators
Inhibitors
Glycolysis and Gluconeogenesis
Glycolysis Function
Glycolysis Location
Glycolysis Connections
Glycolysis Regulation
Glycolysis ATP Yields
Glycolysis Equations
Effect of Arsenate
Lactate or Pyruvate
Gluconeogenesis Function
Gluconeogenesis Location
Gluconeogenesis Connections
Gluconeogenesis Regulation
Gluconeogenesis ATP Costs
Gluconeogenesis Equations
Glycogen Synthesis and Degradation
Function
Location
Connections
Regulation
ATP Yield
ATP Cost
Molecular Features
TCA Cycle
TCA Cycle
Fat Synthesis and Degradation
Fatty Acid Synthesis Function
Fatty Acid Synthesis Location
Fatty Acid Synthesis Connections
Fatty Acid Synthesis Regulation
Fatty Acid Synthesis ATP Costs (for C[subscript 16])
Fatty Acid Synthesis Equation
Elongation and Desaturation
Triglyceride and Phospholipid Synthesis
[beta]-Oxidation Function
[beta]-Oxidation Location
Carnitine Shuttle
[beta]-Oxidation Connections
[beta]-Oxidation Regulation
[beta]-Oxidation ATP Yield
[beta]-Oxidation Equation
[beta]-Oxidation of Unsaturated Fatty Acids
[beta]-Oxidation of Odd-Chain-Length Fatty Acids
Electron Transport and Oxidative Phosphorylation
Oxidation and Reduction
The Electron Transport Chain
Connections
Regulation
P/O Ratios
Uncouplers
Inhibitors
Pentose Phosphate Pathway
Pentose Phosphate Pathway
Amino Acid Metabolism
Nonessential Amino Acid Synthesis
Essential Amino Acids
Amino Acid Degradation
Generalities of Amino Acid Catabolism
Products of Amino Acid Degradation
Integration of Energy Metabolism
Integrating Metabolic Pathways
ATP
Glucose
Storage Molecules
Metabolic States and Signals
Insulin
Glucagon
Epinephrine
Secondary Signals
Generalities of Metabolism
Phosphorylation
Glycogen
Metabolic Movements of Glycogen
Fat
Metabolic Movements of Fat
Protein
Metabolic Movements of Protein
Tissue Cooperation
Liver
Muscle
Adipose
Brain
Connection of Storage Pools
Feeding
Fasting
Starvation
Excitement
Interorgan Cycles
Cori Cycle
Alanine Cycle
Ketone Bodies
Urea Cycle
Urea Cycle
Purine Metabolism
Purine Synthesis
Purine Salvage
Deoxynucleotides
Purine Degradation
Pyrimidine Metabolism
Pyrimidine Synthesis
Pyrimidine Salvage
Pyrimidine Degradation
One-Carbon Metabolism
One-Carbon Metabolism
Oxidation States of Carbon
Tracking Carbons
Glucose to Pyruvate
TCA Cycle
ph, pK[subscript A], Problems
Proton: H[superscript +] or H[subscript 3]O[superscript +]
Acid
Base
Not All Acids and Bases Are Created Equal
pK[subscript a] = -log (K[subscript a])
Weak Acids Make Strong Bases (and Vice Versa)
Who Gets the Proton?
Don't Forget Stoichiometry
The Sadistic Little p
Taking log[subscript 10](x)
Taking -log[subscript 10](x)
pH = -log[subscript 10] [H[superscript +]]
pK[subscript a] = - log[subscript 10] (K[subscript a])
Buffers
Henderson-Hasselbalch Equation
Titration Curves
plIsoelectric Point
The Bicarbonate Buffer
Imbalance in Blood pH
Acidosis and Alkalosis
Thermodynamics and Kinetics
Thermodynamics
Free Energy
Adding Free-Energy Changes
Coupling Free Energies
Thermodynamic Cycles
[Delta]G = [Delta]H - T[Delta]S
Driving Force
Kinetics
Velocity
Transition State Theory
Rate Constants
Rate Constants and Mechanism
Appendix
Glossary
Index

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