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    Neuronal Growth Factors

    ISBN-10: 3642757499
    ISBN-13: 9783642757495
    Author(s): Mark Bothwell
    Description: This book compares and contrasts the biochemistry and biology of nerve growth factor (NGF) and acidic- and basic-fibroblast growth factors in the hope that these extensively characterized factors may serve as useful models for the growing list of  More...
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    Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
    Binding: Paperback
    Pages: 173
    Size: 3.94" wide x 61.42" long x 92.13" tall
    Weight: 657.800
    Language: English

    This book compares and contrasts the biochemistry and biology of nerve growth factor (NGF) and acidic- and basic-fibroblast growth factors in the hope that these extensively characterized factors may serve as useful models for the growing list of less well characterized neurotrophic factors. Nerve growth factor represents one member of a family of several structurally and functionally related peptides; the fibroblast growth factors represent a second large family of peptides. Each family of factors illustrates the important concept that individual peptide factors may have a diverse array of functions on a variety of different cell types. The book thoroughly covers a broad range of topics from the biochemistry of synthesis, processing and release of the factors, to the biochemistry of cell surface receptors and signal transduction mechanisms, to the regulation of expression of factors and receptors in development, to discussions of specific functional roles in the peripheral nervous system and the central nervous system. The volume will be of interest to anyone concerned with the mechanisms governing neural development as well as to those interested in neurodegenerative diseases such as Alzheimer's Disease.

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