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    Handbook of Cardiac Stem Cell Therapy

    ISBN-10: 1848162561
    ISBN-13: 9781848162563
    Author(s): Ioannis Dimarakis, Philippe Menasche, Nagy A. Habib
    Description: This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective,  More...
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    List Price: $158.00
    Publisher: Imperial College Press
    Binding: Hardcover
    Size: 6.50" wide x 9.75" long x 0.75" tall
    Weight: 1.584
    Language: English

    This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals.

    Contributors
    Preface
    The Meritocracy of Stem Cells for Therapy
    References
    Overview of Adult Stem Cell Therapy in Cardiac Disease
    Introduction
    Regenerative Potential of the Native Myocardial Tissue
    Adult Stem Cells
    Other Cell Types
    Homing to Ischaemic Myocardium
    Mechanisms of Cardiac Function Improvement
    Final Comments
    References
    Embryonic Stem Cells and Their Therapeutic Potential
    Embryonic Stem Cells
    ES Cell-Derived Cardiomyocytes
    Other Animal Models for ES Cell-Based Therapeutics
    Barriers to Successful Use of ES Cell-Based Therapies
    Conclusions
    References
    Umbilical Cord Blood Cells for Cardiac Repair
    Introduction
    Myocardial Infarction and Heart Failure
    Myocardial Regeneration and Cell-Based Therapy
    Problems with the Available Cell Sources
    The Rationale for Using UCB Progenitor Cells for Myocardial Repair
    Data from Animal Models
    How Do Cord Blood Cells Repair Ischemic Tissue?
    Ex vivo Expansion
    Immunosuppression and Graft versus Host Disease
    Summary
    References
    Amniotic Stem Cells
    Introduction
    Amniocentesis
    Differentiated Cells from Amniotic Fluid
    Mesenchymal Stem Cells from Amniotic Fluid
    Amniotic Fluid Stem Cells
    Conclusion
    References
    Stem Cell Homing to Injury in Cellular Cardiomyoplasty
    Introduction
    The Prelude: Insights from Bone Marrow Transplantation
    Animal Studies
    The Signaling Molecules
    Summary and Conclusions
    References
    A Molecular Imaging Perspective on Cardiac Repair with Stem Cells
    Introduction
    Radionuclide Imaging
    Optical Imaging
    Ultrasound
    MRI Imaging
    Intracellular MRI Contrast Agents
    MRI Tracking of Stem Cells in the Heart
    Multimodality
    Conclusions
    References
    Marrow Stromal Cells as Universal Donor Cells for Cardiac Regenerative Therapy: Fact or Fancy?
    Introduction
    Maternal-Fetal Cell Microchimerism: A Whisper of the Nature?
    Stem Cell Therapy and Immune Rejection
    Marrow Stromal Cells for Cellular Cardiomyoplasty: An Experimental Study in Porcine/Rat Xenotransplant
    Model Without Immunosuppression
    Mechanisms of MSC Immune Tolerance
    Conclusions
    References
    The Preclinical Basis to Find the Right Choice of Stem Cells for Cardiac Transplantation
    Introduction
    Skeletal Myoblasts (SM)
    Bone Marrow Stem Sells
    Cord Blood Cells
    Cardiac Precursor Cells
    Embryonic Stem Cells
    Closing Remarks
    References
    Bone Marrow-Derived Stem Cells for Treatment of Ischaemic Heart Disease: Background and Experience from Clinical Trials
    Introduction
    Cell Populations
    Selection of Patients
    Administration of the Cells
    Clinical Studies
    Safety
    Discussion
    Conclusion
    References
    Skeletal Myoblast Transplantation for Ischemic Heart Failure
    Theoretical and Experimental Basis for the Use of Skeletal Myoblasts
    Update on Clinical Studies
    Remaining Issues
    Economic Issues
    Methodologic Issues
    References
    Myocardial Tissue Regeneration Observed in Stem-Cell Seeded Bioengineered Scaffolds
    Introduction
    Materials and Methods
    Results
    Discussion
    References
    Stem Cells and Heart Valves
    Introduction
    Modes of Failure in Existing Heart Valves
    Embryologic Development of Native Semilunar Valves
    Structure and Function of the Native Semilunar Heart Valves
    Approaches to a Tissue Engineered Heart Valve
    Differentiated and Stem Cells for Tissue Engineered Heart Valves
    Scaffolds: Polymers
    Tissue Formation: Biochemical and Biophysical Pre-Conditioning
    In Vivo Experiments
    Heart Valve Tissue Engineering: Present and Future
    References
    Potential Applications of Combined Stem Cell and Gene Therapy for the Treatment of Infarcted Heart
    Introduction
    Stem Cells for Cellular Cardiomyoplasty
    Gene Therapy for Myocardial Repair
    Combining Cellular Cardiomyoplasty with Gene Delivery
    Cell Based Gene Delivery to Alleviate Cellular Apoptosis
    Cell Based Gene Delivery for Myogenesis and Electromechanical Integration
    Cell Based Gene Delivery for Angiogenesis
    Angiogenesis Using Genetically Engineered Cells
    Future Directions
    References
    Optimal Expansion and Differentiation of Cord Blood Stem Cells Using Design of Experiments
    Introduction
    Hematopoiesis
    Design of Experiments
    Results and Discussion
    DOE Application in Stem Cell Bioprocessing
    Conclusion
    References
    Index

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