Immune Tolerance:

Name: Immune Tolerance:
Price: 126.67 USD
Availability: InStock
ISBN: 9780879698959

ISBN-10: 0879698950

ISBN-13: 9780879698959

Edition: 2012

Authors: Alexander Rudensky, Diane Mathis

List price: $135.00

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Description:

In autoimmune conditions (e.g., rheumatoid arthritis), the immune systems attacks the host itself, producing severe, debilitating disease. Immune tolerance ensures that the immune system generates T- and B-cell populations that react to foreign antigens rather than to endogenous molecules. This book covers all aspects of central and peripheral tolerance, including positive and negative selection in the thymus, mechanisms that produce clonal anergy, the role of dendritic cells in antigen presentation, and the suppression of autoreactive cells by regulatory T-cells in the periphery. Mechanisms that are defective in autoimmune diseases, and therapeutic strategies targeting them, are also…

Book details

List price: $135.00
Copyright year: 2012
Publisher: Cold Spring Harbor Laboratory Pr
Binding: Cloth Text
Pages: 450
Size: 7.25" wide x 10.25" long x 0.75" tall
Weight: 1.188
Language: English



Preface


Historical Overview of Immunological Tolerance



T-Cell Tolerance: Central and Peripheral



Treg Cells, Life History, and Diversity



Dendritic Cells: Arbiters of Immunity and Immunological Tolerance



Central B-Cell Tolerance: Where Selection Begins



Natural Killer Cell Tolerance: Control by Self or Self-Control?



The Immunogenetic Architecture of Autoimmune Disease



Microbiota and Autoimmunity



Infectious (Non)tolerance-Frustrated Commensalism Gone Awry?



Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases



Index