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    Immune Tolerance:

    ISBN-10: 0879698950
    ISBN-13: 9780879698959
    Edition: 2012
    Description: In autoimmune conditions (e.g., rheumatoid arthritis), the immune systems attacks the host itself, producing severe, debilitating disease. Immune tolerance ensures that the immune system generates T- and B-cell populations that react to foreign  More...
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    List Price: $135.00
    Copyright Year: 2012
    Publisher: Cold Spring Harbor Laboratory Pr
    Binding: Cloth Text 
    Pages: 450
    Size: 7.25" wide x 10.25" long x 0.75" tall
    Weight: 1.188
    Language: English

    In autoimmune conditions (e.g., rheumatoid arthritis), the immune systems attacks the host itself, producing severe, debilitating disease. Immune tolerance ensures that the immune system generates T- and B-cell populations that react to foreign antigens rather than to endogenous molecules. This book covers all aspects of central and peripheral tolerance, including positive and negative selection in the thymus, mechanisms that produce clonal anergy, the role of dendritic cells in antigen presentation, and the suppression of autoreactive cells by regulatory T-cells in the periphery. Mechanisms that are defective in autoimmune diseases, and therapeutic strategies targeting them, are also described.

    Preface
    Historical Overview of Immunological Tolerance
    T-Cell Tolerance: Central and Peripheral
    Treg Cells, Life History, and Diversity
    Dendritic Cells: Arbiters of Immunity and Immunological Tolerance
    Central B-Cell Tolerance: Where Selection Begins
    Natural Killer Cell Tolerance: Control by Self or Self-Control?
    The Immunogenetic Architecture of Autoimmune Disease
    Microbiota and Autoimmunity
    Infectious (Non)tolerance-Frustrated Commensalism Gone Awry?
    Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases
    Index

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